2014
DOI: 10.1161/circulationaha.113.001590
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Cited by 90 publications
(36 citation statements)
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References 177 publications
(173 reference statements)
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“…Although exercise training in general may prevent hypertension by positively affecting endothelial function and arterial stiffness [22,23], repetitive episodes of high-intensity strength or endurance exercise may contribute to a rise in BP, possibly by an increased sympathetic activity [6,20]. However, our study was not intended to demonstrate a causal relationship between endurance sports practice and masked hypertension.…”
Section: Discussionmentioning
confidence: 91%
“…Although exercise training in general may prevent hypertension by positively affecting endothelial function and arterial stiffness [22,23], repetitive episodes of high-intensity strength or endurance exercise may contribute to a rise in BP, possibly by an increased sympathetic activity [6,20]. However, our study was not intended to demonstrate a causal relationship between endurance sports practice and masked hypertension.…”
Section: Discussionmentioning
confidence: 91%
“…Highly reproducible robust improvements in metabolic and cardiovascular profiles occur in response to regular endurance running in human subjects. These include increased insulin sensitivity, reduced levels of triglycerides and cholesterol, reduced blood pressure and resting heart rate, increased heart rate variability, and reduced levels of pro-inflammatory cytokines (for a recent review see Rowe et al, 2014). Endurance exercise increases the number of mitochondria in skeletal muscle, liver and brain cells (Little et al, 2011), which presumably increases their energy production capacity.…”
Section: Challenge 2: Runningmentioning
confidence: 99%
“…At present, perhaps the best intervention to counteract this age-dependent decline in muscle function, termed sarcopenia, is physical exercise. Indeed, accumulating evidence from epidemiological studies and randomized clinical trials illustrates that regular physical activity and endurance exercise benefits a range of human age-related pathologies including sarcopenia, as well as the age-dependent decline in cardiac and cognitive function (Chakravarty et al, 2008; Kosmadakis et al, 2010; Rowe et al, 2014; Stessman et al, 2009; Willis et al, 2012). Interestingly, endurance exercise also conferred phenotypic protection and prevented the premature mortality observed in the mitochondrial mutator mice mentioned above (Safdar et al, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, endurance exercise also conferred phenotypic protection and prevented the premature mortality observed in the mitochondrial mutator mice mentioned above (Safdar et al, 2011). The therapeutic effects of endurance exercise are accompanied by a number of physiological adaptations, however, one of the most beneficial effects appears to be stimulation of mitochondrial biogenesis in a wide variety of tissues including the brain (Arany et al, 2005; Egan and Zierath, 2013; Rowe et al, 2014; Steiner et al, 2011; Wu et al, 2002). Mitochondrial biogenesis is largely coordinated by the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α), (Handschin and Spiegelman, 2008; Ruas et al, 2012).…”
Section: Introductionmentioning
confidence: 99%