Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring

Bick-Sander, Anika; Steiner, Barbara; Wolf, Susanne; Babu, Harish; Kempermann, Gerd

doi:10.1073/pnas.0502644103

Cited by 99 publications

(83 citation statements)

References 62 publications

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“…Prox1 levels are reduced in Mash1-mutant brains, and the overexpression of Mash1 in neural stem cells induces the expression of Prox1, suggesting that Prox1 expression during neurogenesis is Mash1 dependent (Torii et al, 1999). However, Prox1 expression is not restricted only to precursor cells; its expression is also in the mature granule cells of the dentate gyrus during development and in the adult brain (Bick-Sander et al, 2006;Navarro-Quiroga et al, 2006). …”

Section: Introductionmentioning

confidence: 99%

Prox1 expression patterns in the developing and adult murine brain

Lavado

Oliver

2006

Developmental Dynamics

144

124

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Prox1, a homeobox gene related to the Drosophila gene prospero, is necessary for retina, lens, liver, pancreas, and lymphatics development. However, not much is yet known about Prox1 expression during central nervous system development. Here we provide a detailed analysis of Prox1 mRNA and protein expression during prenatal and postnatal murine brain development. Prenatally, Prox1 is expressed in the subventricular zone or in early differentiating regions of the brain. At these stages, Prox1 mRNA, but not Prox1 protein, was also detected in several regions of the prethalamus and hypothalamus. At an early postnatal stage, Prox1 expression is mainly detected in several nuclei of the thalamus, the cerebellum, and the hippocampus. In adulthood, Prox1 expression remains only in the hippocampus and cerebellum. These complex patterns of expression suggest that Prox1 activity is differentially required during brain development and adulthood. Developmental Dynamics 236:518 -524, 2007.

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Section: Introductionmentioning

confidence: 99%

Prox1 expression patterns in the developing and adult murine brain

Lavado

Oliver

2006

Developmental Dynamics

144

124

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“…There is evidence to suggest that habitual levels of maternal activity (grooming and nursing style during lactation) 55 as well as prescribed activity (voluntary wheel running during pregnancy and lactation) 56 have been shown to influence hippocampal neurogenesis. This is consistent with the suggestion that physical activity is heritable.…”

Section: Evidence For Reduced Energy Expenditure In the Offspring Of mentioning

confidence: 99%

Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions

Rooney

Ozanne

2011

Int J Obes

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Obesity now represents one of the major health care issues of the 21st century. Its prevalence has increased exponentially in both the developed and developing world during the last couple of decades. Such a rapid rise can therefore not be explained by a change in genotype, but must result from environmental factors and their interaction with our genes. There is clear evidence to show that current environmental factors such as current diet and level of physical activity can influence our risk of obesity. However, there is growing evidence to suggest that factors acting during very early life can influence long-term energy balance. One such factor that is emerging as an important player is maternal obesity and/or over-nutrition during pregnancy and lactation. Early life may therefore represent a critical period during which intervention strategies could be developed to reduce the prevalence of obesity.

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“…Voluntary wheel running of pregnant mice leads to a twofold increase in hippocampal precursor-cell proliferation in their pups. 48 Maternal physical activity in the form of swimming during pregnancy has also been shown to increase hippocampal BDNF mRNA expression in the offspring leading to improved short-term memory abilities. 49 …”

Section: Influence Of Ee On Brain Developmental Plasticitymentioning

confidence: 99%

Nurturing brain plasticity: impact of environmental enrichment

et al. 2009

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Environmental enrichment (EE) is known to profoundly affect the central nervous system (CNS) at the functional, anatomical and molecular level, both during the critical period and during adulthood. Recent studies focusing on the visual system have shown that these effects are associated with the recruitment of previously unsuspected neural plasticity processes. At early stages of brain development, EE triggers a marked acceleration in the maturation of the visual system, with maternal behaviour acting as a fundamental mediator of the enriched experience in both the foetus and the newborn. In adult brain, EE enhances plasticity in the cerebral cortex, allowing the recovery of visual functions in amblyopic animals. The molecular substrate of the effects of EE on brain plasticity is multi-factorial, with reduced intracerebral inhibition, enhanced neurotrophin expression and epigenetic changes at the level of chromatin structure. These findings shed new light on the potential of EE as a non-invasive strategy to ameliorate deficits in the development of the CNS and to treat neurological disorders.

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Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring

Cited by 99 publications

References 62 publications

Prox1 expression patterns in the developing and adult murine brain

Prox1 expression patterns in the developing and adult murine brain

Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions

Nurturing brain plasticity: impact of environmental enrichment

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