Running reduces stress and enhances cell genesis in aged mice

Kannangara, Timal S.; Lucero, Melanie J.; Gil-Mohapel, Joana; Drapala, Robert J.; Simpson, Jessica M.; Christie, Brian R.; Praag, Henriette van

doi:10.1016/j.neurobiolaging.2009.12.025

Cited by 94 publications

(69 citation statements)

References 40 publications

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“…However, the group that received voluntary exercise before stress induction presented a significantly higher number of nestin-expressing cells over the restraint stress-induced group. This result supports previous studies which found that voluntary wheel running enhanced neurogenesis in mice 35,36 . Brain-derived neurotrophic factor, IGF-1 (insulin like growth factor-1), and neurotrophin are the particular neurotrophic factors which are related to cell survival and cell proliferation.…”

Section: Discussionsupporting

confidence: 93%

The neuroprotective effects of voluntary exercise in a restraint stress model

Jongkamonwiwat¹,

Krityakiarana²

2012

ScienceAsia

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Cell damage and cell generation can be altered in a stressed and exercised brain. However, it is not known whether voluntary exercise can prevent cell damage or cell death in stress situations, especially in the striatal region. To address this question, male Sprague-Dawley rats (3 months old) were separated into three groups (sedentary, restraint stress, and voluntary exercise + restraint stress groups). The stress circumstances were restraint stress, light stress, and tilt cage. To assess cell damage, staining for the heat shock protein (HSP90) was undertaken and the numbers of cells showing positive HSP90 expression were counted. Neurogenesis was investigated by staining for nestin markers. The restraint stress effects were assessed by determining the number of HSP90 expressed cells produced in the dorsal striatum. A significant difference was found when the number of HSP90 positive cells in the restraint stress and the voluntary exercise + restraint stress groups were compared to those in the sedentary control group. In both experimental conditions there was neurogenesis in the striatal area. However, the group that received voluntary exercise presented a significantly higher number of nestin-expressing cells over the restraint stress group. Voluntary exercise might have an adaptive effect on neurogenesis in terms of replenishing the cellular stressed neurons but it has no effect on ameliorating the level of stress marker. The evaluation of the effects of voluntary exercise on neurogenesis in the striatal region in the stressed model might contribute to a better understanding of beneficial interventions in movement disorders related to patients with depression.

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Section: Discussionsupporting

confidence: 93%

The neuroprotective effects of voluntary exercise in a restraint stress model

Jongkamonwiwat¹,

Krityakiarana²

2012

ScienceAsia

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“…An interesting contradiction exists in this respect regarding the direction of the generally positive effect of exercise on AN. Exercise is generally associated with beneficial changes, also in its effects on mood (Ernst et al 2006;Brené et al 2007;Kannangara et al 2011;Vivar et al 2013) and known to potently increase neurogenesis. Paradoxically, GCs are also increased during running.…”

Section: Stress Regulates Adult Hippocampal Neurogenesismentioning

confidence: 99%

Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation

Lucassen

Oomen

Naninck

et al. 2015

Cold Spring Harb Perspect Biol

134

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“…However, according to some reports, exercise can be effective in older animals and has no effect in young animals (17). Research has also found that exercise has little effect in improving memory and does not affect object recognition tasks (13).…”

Section: Introductionmentioning

confidence: 99%