Studies of recorded ground motions and simulations have shown that deep sedimentary basins can greatly increase the intensity of earthquake ground motions within a period range of approximately 1-4 s, but the economic impacts of basin effects are uncertain. This paper estimates key economic indicators of seismic performance, expressed in terms of earthquake-induced repair costs, using empirical and simulated seismic hazard characterizations that account for the effects of basins. The methodology used is general, but the estimates are made for a series of eight-to 24-story residential reinforced concrete shear wall archetype buildings in Seattle, WA, whose design neglects basin effects. All buildings are designed to comply with code-minimum requirements (i.e., reference archetypes), as well as a series of design enhancements, which include (a) increasing design forces, (b) decreasing drift limits, and (c) a combination of these strategies. As an additional reference point, a performance-based design is also assessed. The performance of the archetype buildings is evaluated for the seismic hazard level in Seattle according to the 2018 National Seismic Hazard Model (2018 NSHM), which explicitly considers basin effects. Inclusion of basin effects results in an average threefold increase in annualized losses for all archetypes. Incorporating physics-based ground motion simulations to represent the large-magnitude Cascadia subduction interface earthquake contribution to the hazard results in a further increase of 22% relative to the 2018 NSHM. The most effective of the design strategies considered combines a 25% increase in strength with a reduction in drift limits to 1.5%.