Rupture of the Cervix in Prostaglandin Abortions

Kajanoja, Pauli; Jungner, Gunnar; Wïdholm, O; Karjalainen, O; Seppälä, Markku

doi:10.1111/j.1471-0528.1974.tb00452.x

Cited by 30 publications

(15 citation statements)

References 11 publications

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“…There have been several reports of cervicovaginal fistulae developing after intra-amniotic administration of PGF,".8 [24][25][26] In this study one case was detected in each group, but this may have been an underestimate of the true frequency since postabortal vaginal inspection was not performed in all cases and many patients were lost to follow-up. Ballard et all7 reported four cases of cervicovaginal fistulae among 6000 saline-induced abortions and three among about 300 prostaglandin-induced abortions.…”

Section: Discussionmentioning

confidence: 78%

Comparison of intra-amniotic prostaglandin F2 alpha and hypertonic saline for induction of second-trimester abortion.

1976

BMJ

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DiscussionGrowth, behaviour, and educational achievement are influenced by many factors, and, although we found that the AA and AS children were alike in some of these, we cannot be certain that they were alike in all. Every child, however, had lived since early childhood in a small community in which living standards, child rearing practices, and educational opportunities varied within narrow ranges, and there were unlikely to be major differences in the backgrounds of the two groups.The absence of differences in growth and achievement between children with the two genotypes conflicts with some of the results of the study in the USA,4 in which significantly lower weights and poorer performances in psychological-intellectual tests were found in 19 AS compared with 241 AA children aged 10-16 years. No evidence was presented in that report, however, to show that the two groups were matched for socioeconomic or other factors that might have influenced the measurements. Furthermore, the selection of patients from twin studies may complicate assessment of the results. Perinatal hypoxia is more likely to occur in twins, and, although levels of Hb S are low in the sickle-cell trait at birth, the possible role of severe hypoxia precipitating sickling cannot be entirely excluded.Both studies were limited by small numbers, and carefully controlled investigations of larger groups of children are needed. Meanwhile, the available evidence does not warrant the conclusion that che sickle-cell trait affects physical and mental development. Although PGF,, was associated with a somewhat higher frequency of minor side effects than hypertonic saline, notably vomiting and diarrhoea, these were within acceptable limits. Only 59 women (8 2%) in the prostaglandin group had more than four episodes of vomiting and 11 (151o) more than four episodes of diarrhoea. Other side effects occurred only occasionally. No difference was found between the two groups in the frequency of incomplete abortion or excessive bleeding. IntroductionEarly studies of the intra-amniotic administration of prostaglandin (PG) F,2 showed that doses of 5-25 mg often needed to be repeated to induce therapeutic abortion.'-8 When an initial dose of 25 mg was repeated in 24 hours (if abortion was not

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Section: Discussionmentioning

confidence: 78%

Comparison of intra-amniotic prostaglandin F2 alpha and hypertonic saline for induction of second-trimester abortion.

1976

BMJ

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“…No cervicovaginal fistulae occurred though this has been reported after intra-amniotic hypertonic saline or prostaglandins (Bradley-Watson et al, 1973;Wentz et al, 1973;Kajanoja et al, 1974).…”

Section: Discussionmentioning

confidence: 85%

Prostaglandin-induced Abortion: Assessment of Operative Complications and Early Morbidity

MacKenzie¹,

Hillier²,

Embrey³

1974

BMJ

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SummaryA total of 626 patients undergoing a prostaglandininduced abortion, the majority in the second trimester, have been analysed for complications occurring during inpatient treatment. Of the last 155 consecutive patients 143 were critically assessed six to eight weeks after abortion for morbidity occurring during their early recovery period.Blood loss of 250 ml or more occurred in 68 patients, pyrexia in 34, pelvic infection in three, and readmission in 14 of the 626 patients studied, and a transfusion was required in eight.Bleeding after abortion stopped within six weeks in all 143 of the 155 consecutive patients assessed but three required readmission for uterine curettage. Menstruation was re-established within six weeks of abortion in 106 patients.The incidence of operative morbidity was similar to that reported for first trimester abortion and better than that in most reported series ofsecond trimester abortions.

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“…Gordon (1972) reported a transverse laceration of the posterior fornix resulting in cervico-vaginal fistula, associated with intra-amniotic hypertonic saline and Goodline et al (1972) described 4 further cases, only one of which was recognized at the time of abortion. Severe cervical damage after intra-amniotic urea and prostaglandin F2M (Watson, Beard and Craft, 1972) and cases of cervical rupture after intraamniotic prostaglandin F2 have been described (Wentz et al, 1973;Kajanoja et al, 1974). Burkman et al (1976 had 6 cases using intra-amniotic prostaglandin and urea.…”

Section: Discussionmentioning

confidence: 99%

“…Rupture of the uterus following prostaglandininduced therapeutic abortion is usually of the cervix, although other sites have been described (Emery, Jarvis and Johnson, 1979). Lateral and anterior ruptures have been reported (Kajanoja et al, 1974) but posterior tears are commonest (Kajanoja et al, 1974;Wentz, Thompson and King, 1973;Burkman et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

Rupture of the cervix during prostaglandin termination of pregnancy

El-Etriby¹,

E²

1981

Postgraduate Medical Journal

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Rupture of the Cervix in Prostaglandin Abortions

Abstract: SummaryA total of 412 patients had second trimester abortions and in five of them a rupture of the cervix was detected. An attempt is made to relate the occurrence of this complication to age, parity and to the method of stimulating uterine activity.

Cited by 30 publications

References 11 publications

Comparison of intra-amniotic prostaglandin F2 alpha and hypertonic saline for induction of second-trimester abortion.

Comparison of intra-amniotic prostaglandin F2 alpha and hypertonic saline for induction of second-trimester abortion.

Prostaglandin-induced Abortion: Assessment of Operative Complications and Early Morbidity

Rupture of the cervix during prostaglandin termination of pregnancy

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