Ruptured aneurysm of the right coronary sinus of Valsalva in a child with Down syndrome

Abstract

Aneurysms of one of the aortic sinuses of Valsalva are rare congenital or acquired lesions. Here we present the case of an adolescent with Down syndrome with ruptured aneurysm of the right coronary sinus into the right atrium. All sinuses of Valsalva were normal during cardiological screening owing to Down syndrome at the age of 2 weeks. Paediatricians should have a low threshold for referring patients with Down syndrome for cardiac re-evaluation because of the new onset of cardiac symptoms or cardiac physical findings, even in the situation in which there are normal echocardiographic findings in the past.

Sinus of Valsalva Aneurysm and Infective Endocarditis Involving a Bicuspid Aortic Valve in an Infant With Trisomy 21

“…Bicuspic aortic vavle is a common cardiac malformation affecting 0.5% – 2% of the population, while SoVA has an estimated prevalence of only 0.09% (2, 4). There have been case reports of BAV (6, 7) and SoVA (3, 8) in patients with trisomy 21, but the relative risk of either anomaly’s association with trisomy 21 has not been reported.…”

Sinus of Valsalva Aneurysm in a Patient With Mosaic Trisomy 13: Case Report and Brief Review of the Literature

“…5 Multiple etiologies for Valsalva aneurysms have been suggested and reported, most notably inflammatory processes and connective tissue disorders. Genetic syndromes, including 22q11.2 deletion, 6 Down syndrome, [7][8][9] Wildervanck syndrome, 10 and Noonan syndrome, 11,12 have also been reported. To our knowledge, our case report is the first to report an SOV aneurysm in a patient with trisomy 13.…”

Giant unruptured sinus of Valsalva aneurysm with complete heart block

“…The rupture of SOVA is more frequent into right ventricular outflow tract (60-90%) [1]. The symptomatic aneurysmal dilatation of sinuses is rare in children [3,4]. In general, the rough incidence is 0.09% in the general population.…”