Ruptured Granulosa Cell Tumor of the Ovary as a Cause of Acute Abdomen in Postmenopausal Woman

Öge, Tufan; Ozalp, S. Sinan; Yalçın, Ömer; Kabukçuoğlu, Sare; Arslan, Emine

doi:10.1155/2012/451631

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…Tumour Cyst rupture was found to be associated with poor prognosis in some literature. (32,42)In the present study, presence of tumour cyst rupture was noted only intraoperatively in 3 patients. However, it was not tested against survival, due to low number of patients.…”

Section: Discussionmentioning

confidence: 46%

Adult-type ovarian granulosa cell tumour: Treatment Outcomes from a Single Institutional Experience

Badran

Elshenawy

Soudy

et al. 2019

Preprint

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Background: Ovarian granulosa cell tumour is rare. This study aim is to report the clinical characteristics and long-term outcomes of adult-type OGCT (AOGCT) at King Faisal Specialist Hospital and Research Centre ( KFSH&RC) and to determine the prognostic factors affecting relapse and survival. we retrospectively reviewed patients with AOGCT, from 1988 to 2014, who were treated at our institution. Baseline characteristics, pathological findings, and outcomes were analysed, and reported. RESULTS: Sixty-one patients with AOGCT were identified with a median age of 49 years. Median follow-up was 5.0 years (range 2.1 -8.2 years). 74% of patients were FIGO stage I, whereas 7% stage II, 5% stage III and unknown in 14%. The most common presenting symptoms included abdominal pain (43%) and vaginal bleeding (43%). The majority of patients (38 patients, 62%) were treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. Five (8%) patients received adjuvant chemotherapy. Sixteen patients (26%) relapsed with a median time to relapse of 5.5 years (0.7-8.1 years). Half of the recurrences (8 patients, 50%) occurred after 5 years of diagnosis. Five-year overall survival and disease-free survival were 93% and 84%, respectively. Factors associated with high risk of recurrence were presence of ascites (p=0.000) and elevated preoperative CA 125 level (p=0.048). The overall survival was significantly influenced by the menopausal status (premenopausal 100% vs. postmenopausal 84%; p=0.02), preoperative CA 125 (normal 100% vs. elevated 64%; p=0.005), Ascites (present 33% vs. absent 100%; p=0.000), and age (<55 years 100% vs. ≥ 55 years 77%; p= 0.002). CONCLUSION: This study confirms a good outcome of patients with AOGCT. They require long-term follow-up because the recurrence can occur many years post the definitive therapy. The presence of ascites and elevated preoperative CA 125 levels were associated with a higher risk of recurrence and poor prognosis. The outcome seems not to be affected by fertility-sparing surgery and/or adjuvant chemotherapy.

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Section: Discussionmentioning

confidence: 46%

Adult-type ovarian granulosa cell tumour: Treatment Outcomes from a Single Institutional Experience

Badran

Elshenawy

Soudy

et al. 2019

Preprint

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“…The prognostic effect of tumour cyst rupture time, spontaneously before the operation or iatrogenic rupture during the operation is also controversial. Tumour cyst rupture was found to be associated with poor prognosis in some of the literature [ 34 , 44 ]. In the present study, the presence of tumour cyst rupture was noted only intraoperatively in three patients.…”

Section: Discussionmentioning

confidence: 99%

Adult-Type Ovarian Granulosa Cell Tumour: Treatment Outcomes From a Single-Institution Experience

Alhusaini¹,

Elshenawy²,

Badran³

et al. 2022

Cureus

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Objectives: Ovarian granulosa cell tumour is rare. This study aims to report the clinical characteristics and long-term outcomes of adult-type ovarian granulosa cell tumour (AOGCT) at King Faisal Specialist Hospital and Research Centre (KFSH&RC) and to determine the prognostic factors affecting relapse and survival.Methods: We retrospectively reviewed patients with AOGCT, from 1988 to 2014, who were treated at our institution. Baseline characteristics, pathological findings, and outcomes were analysed and reported.Results: Sixty-one patients with AOGCT were identified with a median age of 49 years. Median follow-up was 5.0 years (range 2.1-8.2 years). 74% of patients were FIGO (International Federation of Gynecology and Obstetrics) stage I, whereas 7% were stage II, 5% were stage III, and unknown in 14% of the cases. The most common presenting symptoms included abdominal pain (43%) and vaginal bleeding (43%). The majority of patients (38 patients, 62%) were treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. Five (8%) patients received adjuvant chemotherapy. Sixteen patients (26%) relapsed with a median time to relapse of 5.5 years (0.7-8.1 years). Half of the recurrences (eight patients, 50%) occurred after five years of diagnosis. Five-year overall survival and disease-free survival (DFS) were 93% and 84%, respectively. Factors associated with a high risk of recurrence were the presence of ascites (p=0.000) and elevated preoperative CA 125 level (p=0.048). The overall survival was significantly influenced by the menopausal status (premenopausal 100% vs. postmenopausal 84%; p=0.02), preoperative CA 125 (normal 100% vs. elevated 64%; p=0.005), ascites (present 33% vs. absent 100%; p=0.000), and age (<55 years 100% vs. ≥ 55 years 77%; p= 0.002). Conclusion:This study confirms a good outcome for patients with AOGCT. They require long-term follow-up as late recurrences can occur many years post definitive therapy. The presence of ascites and elevated preoperative CA 125 levels were associated with a higher risk of recurrence and poor prognosis. Outcomes appear unaffected by fertility-sparing surgery or adjuvant chemotherapy.

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“…Granulosa cell tumors grow to be highly vascular, making them prone to hemorrhagic rupture [3] . Patient presentation of a hemorrhagic GCT is nonspecific and does not always present as hemorrhagic shock [11] , [12] , [13] . The differential diagnosis for spontaneous intra-abdominal bleeding includes splenic rupture, ruptured ovarian cysts, ectopic pregnancy, ruptured abdominal aorta aneurysms and visceral artery aneurysms, and pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Ruptured granulosa cell tumor of the ovary presenting with catastrophic intra-abdominal hemorrhage: A case report

Smith

Kappus

Mojica

et al. 2022

International Journal of Surgery Case Reports

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Ruptured Granulosa Cell Tumor of the Ovary as a Cause of Acute Abdomen in Postmenopausal Woman

Cited by 7 publications

References 8 publications

Adult-type ovarian granulosa cell tumour: Treatment Outcomes from a Single Institutional Experience

Adult-type ovarian granulosa cell tumour: Treatment Outcomes from a Single Institutional Experience

Adult-Type Ovarian Granulosa Cell Tumour: Treatment Outcomes From a Single-Institution Experience

Ruptured granulosa cell tumor of the ovary presenting with catastrophic intra-abdominal hemorrhage: A case report

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