Ruptured Popliteal Aneurysm Resulting from Neurofibromatosis

Bueno, Alicia; Aciń, Francisco; Rodrı́guez, José Manuel; March, José Ramón; Benito, Luis de; Fernández-Casado, Jose L.

doi:10.1177/153857440503900511

Cited by 13 publications

(11 citation statements)

References 35 publications

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“…[5][6][7] Involvement of the peripheral arteries is uncommon; clinical manifestations include abrupt swelling, pain, and hypovolaemic shock caused by massive haemorrhage of the ruptured aneurysm. [8][9][10][11][12][13] Neurofibromatosis causes arterial weakening and haemorrhage. 14 In larger vessels, direct tumour invasion causes tissue compression of the vasovasorum and wall weakening.…”

Section: Discussionmentioning

confidence: 99%

“…The fragility of the vessel walls and hypertrophied surrounding tissue make surgical correction difficult. Although some authors have successfully re-created a vascular channel using a bypass graft, 8,15 many have failed and have adopted salvage procedures such as amputation, resection, and ligation, [11][12][13]16 despite the high mortality and morbidity. Endovascular embolisation is recommended when the circulation distal to the aneurysm is available via collateral vessels.…”

Section: Discussionmentioning

confidence: 99%

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Brachial Artery Aneurysm Rupture in a Patient with Neurofibromatosis: A Case Report

Jeong

Park

Lee

et al. 2008

J Orthop Surg (Hong Kong)

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Peripheral vascular manifestations of neurofibromatosis are rare but may result in fatal haemorrhaging when they rupture. Surgeons should be aware of this life-threatening condition. We report a case of 35-year-old woman with neurofibromatosis who presented with a swollen and tender mass around her right arm. Angiography revealed 2 aneurysms in the brachial artery. Surgical occlusion revealed a large amount of clotted blood within the subfascial space, and the bleeding point was identified as a pinpoint opening in the aneurysm. The brachial artery abutting the aneurysm and the surrounding soft tissues was extremely brittle and fragile, with massive oozing during dissection. The brachial artery was irreparable and was resected after ligation of the artery and surrounding soft tissues and the aneurysm. Despite an uneventful recovery, the patient died on day 4.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Brachial Artery Aneurysm Rupture in a Patient with Neurofibromatosis: A Case Report

Jeong

Park

Lee

et al. 2008

J Orthop Surg (Hong Kong)

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“…Stenotic lesions are the most common, manifesting as cerebral and visceral infarcts, aortic coarctation, and mesenteric ischaemia [Rosser et al, 2005; Oderich et al, 2007]. The vascular abnormalities also predispose to arterio‐venous malformations, fistulae and aneurysms, leading to hemorrhage [Siddhartha et al, 2003; White et al, 2004; Bueno et al, 2005; Ishizu et al, 2006], and to ulceration of the skin and gastrointestinal tract [Obermoser et al, 2004]. Macroscopically, marked vascular fragility has been described [Shimizu et al, 1998].…”

Section: To the Editormentioning

confidence: 99%

Effects of hydrostatic pressure on leporine meniscus cell‐seeded PLLA scaffolds

Gunja

Athanasiou

2009

J Biomedical Materials Res

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Hydrostatic pressure (HP) is an important component of the loading environment of the knee joint. Studies with articular chondrocytes and TMJ disc fibrochondrocytes have identified certain benefits of HP for tissue engineering purposes. However, similar studies with meniscus cells are lacking. Thus, in this experiment, the effects of applying 10 MPa of HP at three different frequencies (0, 0.1, and 1 Hz) to leporine meniscus cell-seeded PLLA scaffolds were examined. HP was applied once every 3 days for 1 h for a period of 28 days. Constructs were analyzed for cellular, biochemical, and biomechanical properties. At t = 4 weeks, total collagen/scaffold was found to be significantly higher in the 10 MPa, 0 Hz group when compared with other groups. This despite the fact that the cell numbers/scaffold were found to be lower in all HP groups when compared with the culture control. Additionally, the total GAG/scaffold, instantaneous modulus, and relaxation modulus were significantly increased in the 10 MPa, 0 Hz group when compared with the culture control. In summary, this experiment provides evidence for the benefit of a 10 MPa, 0 Hz stimulus, on both biochemical and biomechanical aspects, for the purposes of meniscus tissue engineering using PLLA scaffolds.

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“…Other mechanisms of death include cerebrovascular accidents or seizures due to fibromuscular dysplasia with narrowing of major cerebral vessels. Fibromuscular dysplasia has been classified into intimal, intimal aneurysmal, periarterial nodular, and epithelioid forms depending on the degree and type of proliferation, and also into circumscribed, nodular, and diffuse subtypes (33). Vasculopathy resulting in aneurysms may be associated with dissection, rupture, and exsanguination.…”

Section: Neurofibromatosismentioning

confidence: 99%

Forensic Considerations in Cases of Neurofibromatosis—An Overview

Byard

2007

Journal of Forensic Sciences

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Neurofibromatosis types 1 and 2 are inherited neurocutaneous disorders characterized by a variety of manifestations that involve the circulatory system, the central and peripheral nervous systems, the skin, and the skeleton. Significant reduction in lifespan occurs in both conditions often related to complications of malignancy and hypertension. Individuals with these conditions may also be the subject of medicolegal autopsy investigation if sudden death occurs. Unexpected lethal events may be associated with intracranial neoplasia and hemorrhage or brainstem compression. Vasculopathy with fibrointimal proliferation may result in critical reduction in blood flow within the coronary or cerebral circulations, and aneurysmal dilatation may be associated with rupture and life-threatening hemorrhage. An autopsy approach to potential cases should include review of the history/hospital record, liaison with a clinical geneticist (to include family follow-up), a full external examination with careful documentation of skin lesions and nodules, measurement of the head circumference in children, photography, possible radiologic examination, a standard internal autopsy examination, documentation of the effects of previous surgery and/or chemo/radiotherapy, examination for specific tumors, specific examination and sampling of vasculature (renal, cerebral, and cardiac), formal neuropathologic examination of brain and spinal cord, possible examination of the eyeballs, examination of the gastrointestinal tract, histology to include tumors, vessels, gut, and bone marrow, toxicological testing for anticonvulsants, and sampling of blood and tissue for possible cytogenetic/molecular evaluation if required.

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Ruptured Popliteal Aneurysm Resulting from Neurofibromatosis

Cited by 13 publications

References 35 publications

Brachial Artery Aneurysm Rupture in a Patient with Neurofibromatosis: A Case Report

Brachial Artery Aneurysm Rupture in a Patient with Neurofibromatosis: A Case Report

Effects of hydrostatic pressure on leporine meniscus cell‐seeded PLLA scaffolds

Forensic Considerations in Cases of Neurofibromatosis—An Overview

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