Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins

Masullo, Milena; Pìzza, Cosimo; Piacente, Sonia

doi:10.1055/s-0042-119728

Cited by 34 publications

(16 citation statements)

References 50 publications

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“…Also, medicinal properties of saponin containing plants are well known. Some of most prominent examples include Ruscus aculeatus, which is used as vasoprotective agent, or Tribulus terrestris, found in many products dedicated to fertility stimulation in men (Masullo et al 2016;Salgado et al 2017). Steroidal saponins are a research target of many scientist groups.…”

Section: Introductionmentioning

confidence: 99%

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

et al. 2020

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Steroidal saponins are a group of glycosides widely distributed among monocotyledonous families. They exert a wide spectrum of biological effects including cytotoxic and antitumor properties which are the most studied. This review is an update of our previous paper-Saponins as cytotoxic agents (Podolak et al. in Phytochem Rev 9:425-474, 2010) and covers studies that were since published (2010-2018). In this paper we refer to steroidal saponins presenting results of cytotoxicity studies, mechanisms of action and structure-activity relationships.

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Section: Introductionmentioning

confidence: 99%

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

et al. 2020

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“…1) (Challinor and De Voss 2013). Both spirostanol and furostanol saponins have either R or S configuration at 25th carbon position (Masullo et al 2016). Infrared (IR) spectroscopy has been used to differentiate between spirostanol and furostanol saponins.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in steroidal saponins biosynthesis and in vitro production

Upadhyay

Jeena

Shikha

et al. 2018

Planta

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Main conclusion Steroidal saponins exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponins are not sufficient for utilizing them for commercial purpose so in vitro production of saponin by tissue culture, root culture, embryo culture, etc, is necessary for its large-scale production.Saponin glycosides are the important class of plant secondary metabolites, which consists of either steroidal or terpenoidal backbone. Due to the existence of a wide range of medicinal properties, saponin glycosides are pharmacologically very important. This review is focused on important medicinal properties of steroidal saponin, its occurrence, and biosynthesis. In addition to this, some recently identified plants containing steroidal saponins in different parts were summarized. The high throughput transcriptome sequencing approach elaborates our understanding related to the secondary metabolic pathway and its regulation even in the absence of adequate genomic information of non-model plants. The aim of this review is to encapsulate the information related to applications of steroidal saponin and its biosynthetic enzymes specially P450s and UGTs that are involved at later stage modifications of saponin backbone. Lastly, we discussed the in vitro production of steroidal saponin as the plant-based production of saponin is time-consuming and yield a limited amount of saponins. A large amount of plant material has been used to increase the production of steroidal saponin by employing in vitro culture technique, which has received a lot of attention in past two decades and provides a way to conserve medicinal plants as well as to escape them for being endangered.

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“…Results from our previous work (Poljuha et al, ), presented in Table , showed three major phenolic components of A. acutifolius : quercetin‐3‐ O ‐rutinoside (247.90 µg/ml), isorhamnetin‐3‐ O ‐rutinoside (156.10 µg/ml), and kaempferol‐3‐ O ‐rutinoside (12.40 µg/ml). R. aculeatus L. is a very ancient therapeutic plant, extensively used for the treatment of chronic venous insufficiency, varicose veins, and haemorrhoids (Masullo, Pizza, & Piacente, ). In comparison with A. acutifolius and T. communis, R. aculeatus showed very low content of phenolic compounds (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…R. aculeatus L. is a very ancient therapeutic plant, extensively used for the treatment of chronic venous insufficiency, varicose veins, and haemorrhoids (Masullo, Pizza, & Piacente, 2016). In comparison with A. acutifolius and T. communis, R. aculeatus showed very low content of phenolic compounds (Table 1).…”

Section: Re Sults and Discussionmentioning

confidence: 99%

Antiproliferative and pro‐apoptotic activities of wild asparagus (Asparagus acutifoliusL.), black bryony (Tamus communisL.) and butcher's broom (Ruscus aculeatusL.) aqueous extracts against T24 and A549 cancer cell lines

et al. 2019

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The aim of this study was to determine the phenolic profile, antiproliferative, and pro‐apoptotic activities of Asparagus acutifolius, Tamus communis, and Ruscus aculeatus aqueous extracts against human bladder (T24) and lung cancer (A549) cell lines. Antiproliferative activity of the extracts at the concentration range from 0.5 to 4 mg/ml was measured by MTT test, after the incubation period of 4, 24, 48, or 72 hr. Pro‐apoptotic activity of selected plant extracts against T24 and A549 cells was analyzed by flow cytometry at the concentrations of 0.5, 1, and 2 mg/ml. The highest antiproliferative activity against both cancer cell lines was detected by T. communis aqueous extract. The highest pro‐apoptotic effect was achieved by A. acutifolius aqueous extract and its effect was similar against A549 and T24 cells. Practical applications Wild edible plants, such as wild asparagus, black bryony, and butcher’s broom represent important aspect of the Mediterranean diet. They are rich source of various natural bioactive compounds which express different biological activities (antioxidative, antiproliferative, antibacterial, anti‐inflammatory…). The current trend for natural and healthy diet, such as the Mediterranean diet, is in relation to the rapidly growing problem of chronic diseases in a modern society. Wild edible plants have a high direct‐use value using them in dishes containing mixed vegetables, in soup preparation, as natural additives in fermented natural products containing cheese or fish, in water infusions (natural drinks).

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Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins

Cited by 34 publications

References 50 publications

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

Recent advances in steroidal saponins biosynthesis and in vitro production

Antiproliferative and pro‐apoptotic activities of wild asparagus (Asparagus acutifoliusL.), black bryony (Tamus communisL.) and butcher's broom (Ruscus aculeatusL.) aqueous extracts against T24 and A549 cancer cell lines

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