Russell body cervicitis: A case report and literature review

Abstract

Russell bodies are prominent eosinophilic inclusions seen in the cytoplasm of plasma cells and sometimes outside the cell. There are very few publications available in the English literature on Russell Body Cervicitis. Our case is a 40 year old female patient with a positive screening test for HPV DNA. The cervical surface epithelium in biopsy specimens obtained from the cervix completely have eroded intense vesicular eccentric nuclei and large eosinophilic cytoplasm containing focal Russell Body. The infiltration of dense plasma cells were observed. Our case is the fourth case in the English literature. The case is rare and the etiology has not yet been elucidated.

Russell body cervicitis presenting as endocervical polyp: a case report

“…Russell bodies are eosinophilic inclusions of plasma cells in the cytoplasm, and occasionally in extracellular matrix. 2 Russell bodies, first described in 1890 by Russell are referred to as immunoglobulin-containing inclusions, made by abnormal secretion of plasma cells, characterized by distended rough endoplasmic reticulum. The unusual pattern of inflammation has been reported at other sites also due to prolonged antigenic stimulation, as in gastric mucosa, Barret's esopahgus, chronic lymphocytic thyroiditis, rheumatoid arthritis, and ulcerative colitis.…”