Background: Russell's sign is a condition commonly observed in individuals who intentionally induce vomiting and is characterized by the presence of calluses on the dorsum of the hand. 1 This physical manifestation is a significant marker for mental illness and is primarily prevalent among patients diagnosed with eating disorders, such as bulimia nervosa or anorexia nervosa. 2 Meanwhile, delusion disorder is a psychiatric condition with delusion as its main symptom. The diagnosis is often established when a person exhibits the symptoms one or more times, persisting for at least three months. 3 Persecutory delusions are the most common delusion disorder, wherein the patients firmly believe they are being abused or harmed. 5 Despite the significance of Russell's sign, there is limited knowledge regarding its association with other psychiatric conditions. The appearance of its symptoms can provide important clues about the underlying disease.Case Report: We identified a case involving a 50-year-old female who exhibited persecutory delusion. During the examination, we discovered a pale lesion on the back of her right hand. Furthermore, the suspicions of food poisoning drove the patient to frequently induce vomiting after meals, which persisted for five years. We prescribed a daily dosage of 15 mg/day of Aripiprazole tablets to treat this condition. During the treatment, the suspicion towards family members gradually diminished, with total adherence to the prescribed medication.
Conclusion:Russell's sign highlighted the severity of the patient's beliefs and prolonged delusion. Furthermore, this case underscored the significance of conducting a comprehensive physical examination when assessing psychiatric disorders, as it could provide valuable insights for the psychiatrist.