Ruthenium-106 plaque brachytherapy for symptomatic vasoproliferative tumours of the retina

Anastassiou, Gerasimos

doi:10.1136/bjo.2005.081422

Cited by 75 publications

(66 citation statements)

References 10 publications

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“…They are not considered to be hereditary, but one case report describes identical locations of bilateral VPRTs in two homozygotic twins (Wachtlin et al 2002). The majority of tumours (around 75%) are classified as idiopathic (Shields et al 1995;Damato 2006); secondary tumours are associated with multiple causes, such as uveitis (pars planitis), retinitis pigmentosa, toxoplasmosis, toxocara, retinopathy of prematurity (ROP), sickle cell retinopathy, Coats', ocular trauma, longstanding retinal detachment or retinal detachment surgery (Shields et al 1995;Lafaut et al 1999;Heimann et al 2000;Irvine et al 2000;Anastassiou et al 2006;Damato 2006;Tranos et al 2006). A solitary tumour is the most common finding, but multiple and diffuse tumour types also occur.…”

Section: Introductionmentioning

confidence: 99%

“…vessels, with hyalinized vessel walls, exudates and haemorrhages (Irvine et al 2000). Macroscopically the tumours are heterogenous in appearance, probably because of a varying amount of glia and blood vessels (Anastassiou et al 2006). The tumours are characterized by having yellowish or pinkish colour, pathological blood vessels and exudations.…”

Section: Introductionmentioning

confidence: 99%

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Vasoproliferative retinal tumours in a Swedish population

Makdoumi

Crafoord

2009

Acta Ophthalmologica

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Acta Ophthalmol. 2011: 89: 91–94 Abstract. Purpose: To describe the clinical appearance and the visual outcome of a cohort of patients with vasoproliferative retinal tumours (VPRTs) that were diagnosed and treated between 2002 and 2007 at the University Hospital of Örebro. Methods: Nine patients with diagnosed VPRTs were included in a retrospective study. The mean age at the time of diagnosis was 50.2 years (range 7–74 years). Follow‐up time ranged between 14 and 83 months (mean 42.6). Nine out of ten eyes received cryotherapy; six eyes were also treated with photocoagulation. One patient was treated with intravitreal injections of ranibizumab (Lucentis®) and another was referred for brachytherapy. Because of persisting macular oedema, one eye was treated with intravitreal injection of triamcinolon. Results: Of the treated eyes, one had anterior uveitis, six had macular oedema at baseline and four had an exudative retinal detachment at the time of diagnosis. Seven eyes underwent vitrectomy because of epiretinal membranes. Visual acuity at diagnosis was 0.21 (mean) (range 0.02–0.6) and at latest check‐up 0.30 (mean) (range light perception (LP)–1.0), with improvement in six eyes and deterioration in two. Two out of four patients with retinal detachment were successfully treated surgically. Conclusion: VPRTs are benign intraretinal changes. Several complications are associated with this condition. All patients in this study had symptom‐giving tumours and six patients (six eyes) already had profound macular oedema at presentation. In these cases, when complications have already developed, the final visual prognosis is poor, thereby making it important to detect these tumours early. The patient who received anti‐vascular endothelial growth factor (VEGF; Lucentis) therapy showed a slow improvement and distinct regression in exudations during the follow‐up time. However, no increase in visual acuity was seen. At latest examination a peripheral exudative retinal detachment was still observed. Whether anti‐VEGF treatment is effective, as either an alternative or complementary therapy, must be established in the future.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vasoproliferative retinal tumours in a Swedish population

Makdoumi

Crafoord

2009

Acta Ophthalmologica

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“…Primary tumors correspond from 53 to 80% of the cases in the major reported series (7,9,13) . RVPT affects patients of both genders and all ages, but there is a predominance of women after the 5 th decade (7,8,13) . Most patients seek medical attention complaining of decrease in visual acuity, although some cases are discovered on routine evaluation (713) .…”

Section: Clinical Picture and Differential Diagnosismentioning

confidence: 98%

“…RVPT can be primary (idiopathic) or secondary (associated) to other ocular diseases like retinitis pigmentosa, sickle cell retinopathy, Coat's disease, retinopathy of prematurity, toxoplasmosis, toxocariasis, tu berculosis, other uveitis, ocular trauma, retinalchoroidal coloboma and retinal detachment (13,713) . Primary tumors correspond from 53 to 80% of the cases in the major reported series (7,9,13) .…”

Section: Clinical Picture and Differential Diagnosismentioning

confidence: 99%

Retinal vasoproliferative tumor

Marback¹,

Guerra²,

Maia³

et al. 2013

Arq. Bras. Oftalmol.

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“…Many lesions can be effectively managed using triple freeze thaw transconjunctival cryotherapy. 8 Recent studies have also demonstrated that larger lesions can be treated with either ruthenium 106 26 or iodine 27 -plaque brachytherapy. A number of case reports have also appeared in the literature advocating the use of a photodynamic therapy to treat both primary 28,29 and secondary 10 vasoproliferative tumours.…”

Section: Treatmentmentioning

confidence: 99%

Retinal vasoproliferative tumours

Rennie

2010

Eye

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Vasoproliferative tumours are uncommon retinal lesions that may occur in isolation (primary) or in association with another ocular condition (secondary). They may be unilateral or bilateral and have a predilection for the peripheral inferior temporal quadrant of the retina. Vasoproliferative tumours can be associated with abnormalities of the macular, including epiretinal membrane formation and cystoid macular edema. A number of modalities have been used to treat these tumours including cryotherapy and radiotherapy.

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Ruthenium-106 plaque brachytherapy for symptomatic vasoproliferative tumours of the retina

Abstract: beta ray brachytherapy with (1106)Ru plaques was able to control the activity of VTR and retain vision. Cases with secondary glaucoma before treatment had a very poor prognosis.

Cited by 75 publications

References 10 publications

Vasoproliferative retinal tumours in a Swedish population

Vasoproliferative retinal tumours in a Swedish population

Retinal vasoproliferative tumor

Retinal vasoproliferative tumours

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