Ruthenium-catalyzed C–H bond functionalization in cascade and one-pot transformations

Abstract

Ruthenium complexes are well known as remarkable pre-catalysts for challenging C-H bond functionalizations. Combining them with other types of chemical reactions in a tandem or onepot fashion is appealing from a sustainable point of view because it gives access to new strategies to diminish steps devoted to purification and isolation of (sometimes unstable) intermediates. This nonexhaustive review highlights the different approaches enabling these technologies with a particular focus on the understanding for the compatibility of the different reaction sequences. More precisely, ruthenium-catalyzed C-H bond functionalization turned out to be compatible with several organic transformations, metal-mediated reactions and transition metal catalysis.

Maleimides in Directing‐Group‐Controlled Transition‐Metal‐Catalyzed Selective C−H Alkylation

“…The application of ruthenium(II) catalysts in C−H activation has received inspiring progress. It is likely due to their frequently stability to air and water, easy transformation into cyclometalated species by C−H bond cleavage, and compatibility with typically used oxidants [6a,d] . The Ru(II)‐catalyzed C−H alkylation with maleimides has attracted a great deal of attention for a variety of substrates associated to different directing groups were tolerated.…”

Ruthenium-catalysed oxidative coupling of vinyl derivatives and application in tandem hydrogenation

“…Please do not adjust margins Please do not adjust margins functionalizations and hydrogenations which might be considered as sustainable to some extent. 19 Scheme 5. One-pot ruthenium-catalysed oxidative homo-coupling of 1 followed by in situ hydrogenation towards the synthesis of adipic acid ester derivative 3.…”

Ruthenium‐Catalyzed Sulfoalkenylation of Acetanilides and Dual‐Use of the Catalyst Directing Group

“…In particular Ru‐based catalysts are highly reactive in C−H‐activation but at the same time notably less expensive than many other transition metals [20–31] . This topic has been covered in several excellent reviews [32–41] …”

“…[20][21][22][23][24][25][26][27][28][29][30][31] This topic has been covered in several excellent reviews. [32][33][34][35][36][37][38][39][40][41]…”