Ruthenium‐Catalyzed Direct Oxidative Alkenylation of Arenes Through Twofold CH Bond Functionalization in Water: Synthesis of Ethyl (E)‐3‐(2‐Acetamido‐4‐Methylphenyl)Acrylate

Abstract

The article discusses the synthesis of ethyl ( E )‐3‐(2‐acetamido‐4‐methylphenyl)acrylate. Tremendous development in direct olefinations through twofold C–H bond functionalization of arenes and heteroarenes with readily accessible, selective, and rather inexpensive ruthenium catalysts have witnessed. Ruthenium(II)‐catalyzed oxidative alkenylations (a) of benzanilides and benzoic acids, (b) with electron‐withdrawing/ donating coordinating substituents, (c) with heterocyclic directing groups and (d) with heteroarenes have discussed.