Ruthenium-Catalyzed Direct Reductive Amination in HCOOH/NEt3 Mixture

Transfer hydrogenative reductive amination of aldehydes in aqueous sodium formate solution

“…However, using the parent N-tosylethylenediamine ligand, lacking any substitution in the backbone, gave 79% of 5 which was inferior to the 94% yield when Ts-DPEN was used under the same conditions. Notedly, compared with the previously reported reductive amination using Noyori-Ikariya catalyst in HCOOH/NEt 3 mixture, 30 the aqueous catalytic method is limited to aromatic amines.…”

Alternating Chain Growth Copolymerization of Isothiocyanates and Epoxides

“…Aniline was detected in the hydrolyzed products, which was also testified by the LC-MS experiment (Figure S24). As reported in literature, 6,7 primary amine is usually generated during hydrolysis of imine in the presence of acid, which deserves further study in our case.…”

Half-Sandwich Ru(II) Complexes with N,O-Chelate Ligands: Diverse Catalytic Activity for Amine Synthesis in Water

“…Reductive amination (RA) reaction represents one of the simplest and efficient routes to produce amines, because imine was generated in situ in the reaction and the isolation of this intermediate was alleviated . Recently, reductive amination catalyzed by transition metal complexes from carbonyl compounds through transfer hydrogenation is a green, direct, and versatile method for the synthesis of amines. , So such reaction under catalysis of half-sandwich ruthenium complexes Ru1 – Ru4 was investigated.…”

“…Reductive amination reactions between carbonyl compounds and amines in the presence of a reducing agent represent a highly efficient and facile route to amine synthesis because of the readily available starting materials, convenient one-pot synthetic procedure, and broad substance scope. , Thus, various types of catalysts (including heterogeneous and homogeneous) have been prepared and employed in the reductive amination reaction due to the prominent efficiency in carbon–nitrogen bond formation. − For heterogeneous catalysts, one of the most notable drawbacks is their poor chemoselectivity in RA reactions . Development of efficient homogeneous catalysts of RA reactions (including transfer hydrogenation and catalytic hydrogenation) has attracted considerable attention in recent years. , However, the catalysts with good efficiency in both hydrogenative and transfer hydrogenative RA reactions are rarely reported . Such catalysts are attractive because they could be employed in different reaction conditions.…”