Ruthenium-catalyzed intermolecular alkene–alkyne couplings in biologically relevant media

Abstract

Cationic cyclopentadienyl Ru(II) catalysts can efficiently promote mild intermolecular alkyne-alkene couplings in aqueous media, even in the presence of different biomolecular components, and in complex media like DMEM. The method...

Lewis acid-driven self-assembly of diiridium macrocyclic catalysts imparts substrate selectivity and glutathione tolerance

“…[7][8][9][10][11] For example, molecular inorganic catalysts (MICs) have been used to mediate intracellular C-C bond crosscoupling, 12 olen metathesis, 13,14 protecting group cleavage, [15][16][17][18] transfer hydrogenation, 19,20 and others. [21][22][23] Unfortunately, since MICs lack the ability to restrict access to their active sites, they are prone to inhibition by endogenous thiols 21,24,25 and have poor substrate selectivity. These deciencies severely limit their practical applications in living environments.…”