Ruthenium‐Catalyzed Pyridyl‐Directed C−H Allylation of Arenes with 1‐Aryl‐2‐vinylpyrrolidines

Abstract

The [Ru(p‐cymene)Cl2]2‐catalyzed reaction of 2‐arylpyridines with 1‐aryl‐2‐vinylpyrrolidines is carried out in CF3CH2OH at 40 °C in the presence of KOAc, affording ortho‐C‐H allylation products of arenes in 29% to 99% yields and 1:0.7 to 1:5.4 Z/E ratio. The amino groups remain in the product molecules. The protocol suits for a wide scope of substrates and tolerates functional groups including alkyl, aryl, MeO, F, Cl, Br, OCF3, and CF3 groups.