Ruthenium complex-catalyzed coupling of vinyl halides with olefins

Conformational analogues of Oxamflatin as histone deacetylase inhibitors

“…† Assignment of the isomers was based on comparison of the coupling constants for the 1 H NMR spectrum of partially purified 4(Z) isomer 17a (J 2,3 = 15.3, J 3,4 = 11.6 and J 4,5 = 11.6 Hz) to those reported for similar compounds in the literature. 12,13 Overlapping resonances for H4 and H5 prevented determination of J 4,5 for the 4(E) isomer 17b.…”

“…1 H NMR (300 MHz, CDCl 3 ) d = 1.41 (t, J = 7.1 Hz, 3H, ethyl CH 3 ), 4.41 (q, J = 7.1 Hz, 2H, ethyl CH 2 ), 6.71 (ddd, J = 8.0, 2.3, 1.0 Hz, 1H, H4 ), 6.94 (m, 1H, H2 ), 7.02 (ddd, J = 7.7, 1.7, 1.0 Hz, 1H, H6 ), 7.25 (apparent t, J = 7.9 Hz, 1H, H5 ), 7.48 (td, J = 7.8, 0.4 Hz, 1H, H5), 7.75 (ddd, J = 7.8, 1.9, 1.3 Hz, 1H, H4), 8.01 (dt, J = 7.8, 1.3 Hz, 1H, H6), 8.25 (m, 1H, H2). 13…”

“…1 H NMR (300 MHz, CDCl 3 ) d = 1.41 (t, J = 7.1 Hz, 3H, ethyl CH 3 ), 3.07 (s, 3H, SO 2 CH 3 ), 4.41 (q, J = 7.1 Hz, 2H, ethyl CH 2 ), 7.23 (s, 1H, NH), 7.27-7.50 (m, 5H, H5, H2 , H4 , H5 and H6 ), 7.75 (ddd, J = 7.8, 1.9, 1.2 Hz, 1H, H6), 8.04 (dt, J = 7.8, 1.4 Hz, 1H, H4), 8.25 (m, 1H, H2). 13…”

“…1 H NMR (300 MHz, DMSO) d = 1.69 (m, 6H, pyran H3, pyran H4 and pyran H5), 3.07 (s, 3H, SO 2 CH 3 ), 3.58 (m, 1H, pyran H6), 4.08 (m, 1H, pyran H6), 5.07 (s, 1H, pyran H2), 7.30 (m, 1H), 7.50 (m, 3H), 7.62 (t, J = 7.8 Hz, 1H, H5), 7.82 (dm, J = 7.8 Hz, 2H, H4 and H6), 8.03 (m, 1H, H2). 13…”

Ruthenium Complex-Catalysed Heck Reactions of Areneboronic Acids; Mechanism, Synthesis and Halide Tolerance

“…[12] Since that publication, catalysis of Heck reactions by ruthenium black under very simple conditions has been demonstrated. [13] Further examples of oxidative Heck reactions involving palladium or rhodium have appeared.…”