Ruthenium(II)–arene and triruthenium-carbonyl cluster complexes with new water-soluble phopsphites based on glucose: Synthesis, characterization and antiproliferative activity

Ruthenium(II)–Arene Complexes with Glycosylated NHC-Carbene Co-Ligands: Synthesis, Hydrolytic Behavior, and Binding to Biological Molecules

“…Previously it was shown that some related RAPTA-type complexes are similarly not cytotoxic . Other ruthenium–arene complexes with carbohydrate-derived ligands were previously reported − and many of these derivatives are noncytotoxic or moderately cytotoxic. The higher cytotoxicity of 9 may be attributed to the presence of the hydrophobic phenanthroline ligand that is expected to enhance cellular uptake. − …”

Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PLpro

“…Some tested compounds are commercially available and they were purchased from Sigma Aldrich (sodium aurothiomalate hydrate, gold(III) chloride hydrate, chloro(triethylphosphine)gold(I), chloro(triphenylphosphine)gold(I), thiomersal), Acros Organics (silver sulfadiazine, titanocene dichoride, cisplatin, disulfiram), Adipogen‐Biomol (chloroquine diphosphate) and Enzo Life Sciences (auranofin). The following complexes were prepared as previously described in the literature: Au‐7 [51] , Au‐8 [52] , Au‐9 , Au‐11 [53] , Au10 [54] , Au‐12 , Au‐13 [55] , Au‐15 [52] , Au‐20 , Au‐25 , Au‐26 [56] , Au‐27 [57] , Au‐31 – Au‐32 [55] , Au‐33 , Au‐34 [58] , Ru‐1 , Ru‐4 – Ru‐8 , [59] , Ru‐10 [60] , Ru‐11 [61] , Ru‐12 [62] , Ru‐13 [63] , Ru‐14 , Ru‐15 , Ru‐16 [64] , Mn‐1 , Mn‐2 [65] , Re‐1 [66] , Re‐2 [67] , Pt‐2 [68] , Pt‐3 , Pt‐4 , Pd‐1 , Pd‐2 [69] , Fe‐1 , Fe‐2 , Fe‐3 , Fe‐4 [70] , Fe‐5 [71] , Fe‐6 [72] , Fe‐7 , Fe‐8 [73] Fe‐9 [74] , Fe‐10 [75] , Fe‐11 [76] , Fe‐13 [77] , POM‐1 , POM‐2 [27] , POM‐3 [28] , POM‐4 [29] , POM‐5 [30] , POM‐6 , POM7 [31] , POM‐8 , POM‐9 , POM‐10 [32] , POM‐11 [33] . For preparation and characterization of all other complexes see the supporting information.…”

Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand

“…The IC 50 value for the dodecane-bridged bis-Ru complex in SW480 cancer cells was similar to that of platinum reference compounds and was an order of magnitude lower than of the clinically-studied Ru(III) compound KP1019 ( Mendoza-Ferri et al, 2008 ; Mendoza-Ferri et al, 2009 ; Nováková et al, 2009 ; Nazarov et al, 2018 ), while the mononuclear analog gave IC 50 values greater than 100 µM, indicating a lack of cytotoxic activity ( Mendoza-Ferri et al, 2008 ). Multimetallic triruthenium-carbonyl clusters ( Gonchar et al, 2020 ) have also been found to be cytotoxic, and the most active of these clusters was shown to be a system that featured a glucose-inspired phosphorus ligand. The IC 50 values for the clusters were in the sub-µM range for wildtype and cisplatin-resistant human ovarian cancer cells ( Gonchar et al, 2020 ).…”

“…Multimetallic triruthenium-carbonyl clusters ( Gonchar et al, 2020 ) have also been found to be cytotoxic, and the most active of these clusters was shown to be a system that featured a glucose-inspired phosphorus ligand. The IC 50 values for the clusters were in the sub-µM range for wildtype and cisplatin-resistant human ovarian cancer cells ( Gonchar et al, 2020 ). Further to this triruthenium cluster, we have investigated the use of easily synthesized ditopic ligands to form homodimetallic complexes ( Figure 1 , top left).…”