Ruthenium(II) bipyridine complexes incorporating (NN′S) azoimine ancillary ligands. Synthesis, spectroscopy, solid state structure and DFT calculations

Herein we illustrate the formation and characterization of new paramagnetic ruthenium compounds, trans-P-[RuCl(PPh 3 ) 2 (pmt)]Cl(1)Agarose gel electrophoresis experiments of the metal compounds illustrated dose-dependent binding to gDNA by 1-3, while methylene blue competition assays suggested that 1 and 2 are also DNA intercalators. Assessment of the effects of the compounds on topoisomerase function indicated that 1-3 are capable of inhibiting topoisomerase I activity in terms of the ability to nick supercoiled plasmid DNA. The cytotoxic activities of the metal complexes were determined against a range of cancer cell lines versus a nontumorigenic control cell line, and the complexes were, in general, more cytotoxic towards the cancer cells, displaying IC 50 values in the low micromolar range. Time-dependent stability studies showed that in the presence of strong nucleophilic species (such as DMSO), the chloride co-ligands of 1-3 are rapidly substituted by the former as proven by the suppression of the substitution reactions in the presence of an excess amount of chloride ions. The metal complexes are significantly stable in both DCM and an aqueous phosphate buffer containing 2 % DMSO.

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Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

Maikoo

Xulu

Mambanda

et al. 2022

ChemMedChem

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Corrosion inhibition of carboxylate substituted amidrazone on mild steel in 3% NaCl medium: Electrochemical, DFT and molecular dynamics simulation studies

Al-Noaimi

Benabid

Hamani

et al. 2022

Chemical Data Collections

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Synthesis, X-ray structure, spectroscopic, DFT study and catalytic activity of cis-[RuCl2(L)(EPh3)] complexes (E = P, As, Sb; L = NN′N″ tridentate azoimine-quinoline ligands)

Al-Noaimi

Hammoudeh

Awwadi

et al. 2018

Inorganica Chimica Acta

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Ruthenium(II) bipyridine complexes incorporating (NN′S) azoimine ancillary ligands. Synthesis, spectroscopy, solid state structure and DFT calculations

Cited by 7 publications

References 37 publications

Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

Corrosion inhibition of carboxylate substituted amidrazone on mild steel in 3% NaCl medium: Electrochemical, DFT and molecular dynamics simulation studies

Synthesis, X-ray structure, spectroscopic, DFT study and catalytic activity of cis-[RuCl2(L)(EPh3)] complexes (E = P, As, Sb; L = NN′N″ tridentate azoimine-quinoline ligands)

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Ruthenium(II) bipyridine complexes incorporating (NN′S) azoimine ancillary ligands. Synthesis, spectroscopy, solid state structure and DFT calculations

Cited by 7 publications

References 37 publications

Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

Corrosion inhibition of carboxylate substituted amidrazone on mild steel in 3% NaCl medium: Electrochemical, DFT and molecular dynamics simulation studies

Synthesis, X-ray structure, spectroscopic, DFT study and catalytic activity of cis-[RuCl2(L)(EPh3)] complexes (E = P, As, Sb; L = NN′N″ tridentate azoimine-quinoline ligands)

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Synthesis, X-ray structure, spectroscopic, DFT study and catalytic activity of cis-[RuCl2(L)(EPh3)] complexes (E = P, As, Sb; L = NN′N″ tridentate azoimine-quinoline ligands)