Ruthenium (II) complexes of thiosemicarbazone: Synthesis, biosensor applications and evaluation as antimicrobial agents

Yıldırım, Hatice; Guler, Emine; Yavuz, Murat; Öztürk, Nurdan; Yaman, Pelin Köse; Subaşı, Elif; Şahi̇n, Elif; Timur, Suna

doi:10.1016/j.msec.2014.08.007

Cited by 44 publications

(32 citation statements)

References 60 publications

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“…9,16 The bacterial strains were inoculated into 25 mL of Nutrient Broth (Oxoid) medium in an orbital shaker at 200 rpm for 4 to 6 h until a turbidity of 0.5 McFarland (1 × 10 8 CFU/mL) was reached. Final inoculum on Nutrient Agar (NA, Merck) plates was adjusted to 5 × 10 5 CFU/mL.…”

Section: Synthesis Of the Complexesmentioning

confidence: 99%

“…These results were also confirmed by early works. 9,16 It has been suggested that the mechanism of the antimicrobial effects incorporates the inhibition of various cellular procedures, followed by an increase in plasma membrane permeability and in the end ion leakage from the cells. 30 In other respects, the variation of susceptibility between Gram-negative and Gram-positive bacteria could be as regards to their essential properties that are related to the permeability of their cell surface to the conformationally stable half-sandwich ruthenium(II)-arene complexes (I-III).…”

Section: Antimicrobial Activity Of Organometallic Ruthenium(ii)-arenementioning

confidence: 99%

“…30 In other respects, the variation of susceptibility between Gram-negative and Gram-positive bacteria could be as regards to their essential properties that are related to the permeability of their cell surface to the conformationally stable half-sandwich ruthenium(II)-arene complexes (I-III). 9,30 Figure 4A) and control strain S. aureus ATCC 25923 strains, respectively. Further, the complex III exhibited the best antibacterial activity (16 mm inhibition zone at 100 µg/disc) against B. subtilis ATCC 11774 ( Figure 4B) compared with the activity of the tested antibiotics.…”

Section: Antimicrobial Activity Of Organometallic Ruthenium(ii)-arenementioning

confidence: 99%

“…[3][4][5][6][7][8] Their biological activities are considered to play a vital role in biological systems due to the TSCs to chelate with trace metal ions. 8,9 Optimization of these type molecules can result in discovery of new class therapeutic agents. There has been great regard in the chemistry and medicine of organometallic ruthenium(II)-arene complexes as the improvement of effective synthetic precursors.…”

Section: Introductionmentioning

confidence: 99%

“…9 The structural characterization and oxygen sensitivity of ruthenium(II) carbonyl complexes were also studied and their antimicrobial activities were determined by our research group. 16 We reported that arene containing ruthenium(II) complexes show higher antimicrobial activity than the others.…”

Section: Introductionmentioning

confidence: 99%

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p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

Yavuz¹,

Yaman²,

Öztürk³

et al. 2017

Dicle Tıp Dergisi

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Objective: Thiosemicarbazone (TSC) containing three new mononuclear ruthenium(II)-arene complexes were synthesized so as to contribute to the development of ruthenium complexes with pharmacologically attracted properties.Conclusion: The TSC 1-3 containing ruthenium(II)-arene complexes were successfully synthesized and their molecular structures were also determined by the spectroscopic methods. All ruthenium(II)-arene complexes showed higher antibacterial activities against Gram-positive bacterial strains than the Gram-negative ones. Original Article/Özgün AraştırmaKeywords: Half-sandwich Ru(II)-arene complexes, benzaldehyde thiosemicarbazone, p-cymene, antimicrobial activity, clinical isolate.Results: The spectroscopic data indicated that TSC 1 was bounded to the metal as a tridentate ligand with its thione sulfur atom, phenolic oxygen atom and azomethine nitrogen atom in the complex I, while TSC 2 and TSC 3 were bounded to metal center as bidentate manner through their thione sulfur atom and imine nitrogen (C=N) atom in the complexes II and III, respectively. The obtained antimicrobial activity results showed that these complexes efficiently inhibit the growth of Gram-positive bacterial strains.

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Section: Synthesis Of the Complexesmentioning

confidence: 99%

Section: Antimicrobial Activity Of Organometallic Ruthenium(ii)-arenementioning

confidence: 99%

Section: Antimicrobial Activity Of Organometallic Ruthenium(ii)-arenementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

Yavuz¹,

Yaman²,

Öztürk³

et al. 2017

Dicle Tıp Dergisi

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Synthesis, Characterization, and Biological Investigation of Antimony(III) Halide Complexes With Different Coordination Architectures Constructed From Thiophene Thiosemicarbazones

Ucar,

Ozturk,

Grześkiewicz

et al. 2024

Applied Organom Chemis

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In this study, we report the synthesis, characterization, and biological investigation of antimony(III) halide complexes with various coordination architectures constructed from thiophene thiosemicarbazones. Antimony(III) thiophene‐2‐carbaldehyde thiosemicarbazone complexes (1, 2, 4, and 5) exhibit a square pyramidal geometry, with ligands coordinated to the central antimony atom in two distinct binding modes. In contrast, antimony(III) 2‐acetylthiophene thiosemicarbazone complexes (3, 6, and 7) adopt a seesaw geometry. These complexes (1–7) represent the first reported examples of antimony(III) halide thiosemicarbazone compounds. The unique coordination environments observed in these complexes are of significant importance within the realm of antimony chemistry. These synthesized complexes exhibit different coordination geometries as well as potential biological activities. The antiproliferative activity against the human breast adenocarcinoma (MCF‐7) cell line and antimicrobial activity against Gram‐positive and Gram‐negative bacteria were assessed. Antimony(III) thiophene‐2‐carbaldehyde thiosemicarbazone complexes (1, 2, 4, and 5) showed significant antiproliferative activity with IC50 values ranging from 8.5 to 19.1 μM, while antimony(III) 2‐acetylthiophene thiosemicarbazone complexes (3, 6, and 7) had higher IC50 values. Additionally, the antimony complexes demonstrated selective antimicrobial activity against Gram‐negative bacteria.

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Thiophene‐containing compounds with antimicrobial activity

Roman¹

2022

Archiv der Pharmazie

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Thiophene, as a member of the group of five-membered heterocycles containing one heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the accurate positioning of various functionalities onto the thiophene ring. This review provides a comprehensive, systematic and detailed account of the developments in the field of antimicrobial compounds featuring at least one thiophene ring in their structure, over the last decade.

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Ruthenium (II) complexes of thiosemicarbazone: Synthesis, biosensor applications and evaluation as antimicrobial agents

Cited by 44 publications

References 60 publications

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

Synthesis, Characterization, and Biological Investigation of Antimony(III) Halide Complexes With Different Coordination Architectures Constructed From Thiophene Thiosemicarbazones

Thiophene‐containing compounds with antimicrobial activity

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