2023
DOI: 10.1002/chem.202202694
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Ruthenium(II)‐Dithiocarbazates as Anticancer Agents: Synthesis, Solution Behavior, and Mitochondria‐Targeted Apoptotic Cell Death

Abstract: The reaction of the Ru(PPh 3 ) 3 Cl 2 with HL 1À 3 À OH (À OH stands for the oxime hydroxyl group; HL 1 À OH = diacetylmonoxime-S-benzyldithiocarbazonate; HL 2 À OH = diacetylmonoxime-S-(4-methyl)benzyldithiocarbazonate; andgives three new ruthenium complexes [Ru II (L 1À 3 À H)(PPh 3 ) 2 Cl] (1-3) (À H stands for imine hydrogen) coordinated with dithiocarbazate imine as the final products. All ruthenium(II) complexes (1-3) have been characterized by elemental (CHNS) analyses, IR, UV-vis, NMR ( 1 H, 13 C, and … Show more

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Cited by 20 publications
(26 citation statements)
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“…Also, in the case of A549 cells, the PCC values were found to be 0.77, 0.83, 0.83, and 0.82 for 1 – 4 , respectively, suggesting the high selectivity of the compounds toward the mitochondria. Thus, compounds with higher hydrophobic behavior have a higher tendency to gather in the lipid organelles like mitochondria owing to their negative potential difference across the membrane. ,, …”
Section: Results and Discussionmentioning
confidence: 99%
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“…Also, in the case of A549 cells, the PCC values were found to be 0.77, 0.83, 0.83, and 0.82 for 1 – 4 , respectively, suggesting the high selectivity of the compounds toward the mitochondria. Thus, compounds with higher hydrophobic behavior have a higher tendency to gather in the lipid organelles like mitochondria owing to their negative potential difference across the membrane. ,, …”
Section: Results and Discussionmentioning
confidence: 99%
“…In order to determine whether complex-induced cell death occurs by apoptosis or necrosis, a biparametric flow cytometric analysis using annexin V-FITC and PI double staining assays was performed. , As shown in Figure , after the treatment of 2 (0.5 × IC 50 , 1.0 × IC 50 , and 2.0 × IC 50 ), the percentage of apoptotic cells increases significantly (88.5%) compared to the control (10.0%) at higher concentrations. However, the necrotic cell contents were also observed, i.e., 50.8% at 0.5 × IC 50 concentration, but a steady decrease in the cell number was observed with an increase in the concentration of 2 .…”
Section: Results and Discussionmentioning
confidence: 99%
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