Ruthenium(II) piano stool coordination compounds with aminomethylphosphanes: Synthesis, characterisation and preliminary biological study in vitro

Polymeric micelle-mediated delivery of half-sandwich ruthenium(II) complexes with phosphanes derived from fluoroloquinolones for lung adenocarcinoma treatment

“…2, SI, Table S1). formation [10]. This suggests that extension of piperazine ring with heterocyclic moiety of fluoroquionolones do not affect the Ru-phosphane coordination significantly.…”

“…Herein, we present the synthesis, physicochemical characterization, and preliminary biological study on anticancer activity in vitro evaluated towards lung adenocarcinoma of four novel piano-stool ruthenium(II) complexes. These organometallic complexes are an extension of the mono(aminomethyl)phosphane complex (RuPP 1 ) reported recently [10], in which Nethylpiperazine ring was replaced by heterocyclic moieties of fluoroquinolones: ciprofloxacin (RuPCp), sparfloxacin (RuPSf), norfloxacin (RuPNr) and lomefloxacin (RuPLm) (Fig. 1).…”

“…In consequence, solvolised ruthenium(II) complex may exhibit totally different activity in vitro in comparison to a parent dichlorido compound. In the case of the half-sandwich ruthenium(II) complex RuPP 1 , studied by us previously and treated as the parent complex, we observed that this complex was susceptible to decomposition [10]. Thus, in order to avoid solvolysis of metal complexes various delivery systems such as mentioned above formulations loaded with these complexes have been currently proposed.…”

“…In our group we are focused on synthesis and characterization of metal complexes with phosphanes -a very interesting class of ligands with great capacity to structural modifications and tuning their physicochemical and, in consequence, biological properties. The majority of ruthenium(II) aminomethylphosphanes' coordination compounds exhibited cytotoxicity in vitro against cancer cells close to cisplatin [10]. Moreover, the synthesized copper(I) and copper(II) complexes with phosphanes modified with quinolones (i.e., ciprofloxacin PCp, sparfloxacin PSf, lomefloxacin PLm, norfloxacin PNr) turned out to be more active than the parent antibiotics, and noteworthy possessed cytotoxicity in vitro towards selected cancer cell lines higher than cisplatin [11][12][13][14].…”

New diphenylphosphane derivatives of ketoconazole are promising antifungal agents

“…Our team has been working with this class of ligands and their Cu(I), Pt(II) and Ru(II) complexes and, in many cases, the properties of the derivatized molecules and their complexes are more interesting than the parent ones. For example, we worked with trisaminomethylphosphanes derived from morpholine and thiomorpholine (see for example refs 34–37 ) and a variety on N4-substituted piperazines 34,35,38–41 , as well as with monoaminomethyldiphenylphosphanes 40–42 , including a derivative of a model dipeptide 43 and the derivatives of selected fluoroquinolones: ciprofloxacin, norfloxacin 44–46 , lomefloxacin 47 and sparfloxacin 48–50 . Some of the compounds listed above showed interesting antimicrobial and/or anti-tumour activity.…”