Ruthenium (III) catalysed and uncatalysed oxidation of torsemide by hexacyanoferrate (III) in aqueous alkaline medium: A kinetic comparative approach

Ravindra, K.; Shastry, Vidyavati; Kumar, Mohan; Nagarajaiah, H.; Ramyashree, H.

doi:10.1016/j.jics.2021.100104

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…2,[4][5][6] The plasma elimination half-life of torasemide was approximately 3.5 hours. 4 Torasemide is a white-to-off-white, odorless crystalline powder with 7 an empirical form of C 16 H 20 N 4 O 3 S and a molecular weight of 348.43 g/mol. 8 The acid dissociation constant (pKa) values of torasemide were 7.1, 9 and the lipophilicity (LogP) value was 1.76.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Critical Review of Clinical Pharmacokinetics of Torasemide

Sherazi,

Zamir,

Rehman

et al. 2024

Therapeutic Drug Monitoring

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Purpose: Torasemide is a potassium-sparing loop diuretic used to treat fluid retention associated with congestive heart failure and kidney and hepatic diseases. This systematic review was conducted to combine all accessible data on the pharmacokinetics (PK) of torasemide in healthy and diseased populations, which may help clinicians avert adverse drug reactions and determine the correct dosage regimen. Methods: Four databases were systematically searched to screen for studies associated with the PK of torasemide, and 21 studies met the eligibility criteria. The review protocol was registered in the PROSPERO database (CRD42023390178). Results: A decrease in maximum plasma concentration (Cmax) was observed for torasemide after administration of the prolonged-release formulation in comparison to that after administration of the immediate-release formulation, that is, 1.12 ± 0.17 versus 1.6 ± 0.2 mcg/mL. After administering an oral dose of torasemide, a 2-fold increase in the area under the concentration–time curve (AUC) was reported in patients with congestive heart failure compared with the healthy population. Moreover, the patients with renal failure (clearance < 30 mL/min) showed an increase in value of AUC0–∞ that is, 42.9 versus 8.091 mcg.h−1.mL−1 compared with healthy subjects. In addition, some studies have reported interactions with different drugs, in which irbesartan showed a slight increase in the AUC0–∞ of torasemide, whereas losartan and empagliflozin did not. Conclusions: The current review summarizes all available PK parameters of torasemide that may be beneficial for avoiding drug–drug interactions in subjects with renal and hepatic dysfunction and for predicting doses in patients with different diseases.

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Section: Introductionmentioning

confidence: 99%

A Systematic Critical Review of Clinical Pharmacokinetics of Torasemide

Sherazi,

Zamir,

Rehman

et al. 2024

Therapeutic Drug Monitoring

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Non-precious metal-based integrated electrodes for overall alkaline water splitting

Manojkumar¹,

Kandeeban²,

Brindha³

et al. 2022

Journal of the Indian Chemical Society

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Kinetics and oxidation of thiocarbohydrazide by hexacyanoferrate(III) in aqueous perchloric acid medium

Seetharam,

Shastry,

Shashidhar

et al. 2023

Nano Carbons

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Hexacyanoferrate(III) [HCF(III)] was used to oxidize thiocarbohydrazide (TCH) in an aqueous perchloric acid (HClO4) medium, and the reaction kinetics were studied spectrophotometrically at 420 nm while keeping a constant ionic strength of 1.0 mol dm−3 and modulating the temperature between 298K–318K. The stoichiometry of the reaction among TCH and HCF in the HClO4 medium is 1:2. The reaction has a lower than unit order in both TCH and HClO4 and is of the first order in HCF. The impact of varying the ionic strength and dielectric constant of the medium on the rate has been investigated. The effect of temperature on the reaction rate was studied, and different activation parameters of reaction Ea, ΔH#, ΔS#, ΔG#, and log10 A were calculated. The products of oxidation were analyzed by simple qualitative analysis. On the basis of the collected data, the rate law has been derived, and a probable mechanism has been proposed.

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Ruthenium (III) catalysed and uncatalysed oxidation of torsemide by hexacyanoferrate (III) in aqueous alkaline medium: A kinetic comparative approach

Cited by 3 publications

References 16 publications

A Systematic Critical Review of Clinical Pharmacokinetics of Torasemide

A Systematic Critical Review of Clinical Pharmacokinetics of Torasemide

Non-precious metal-based integrated electrodes for overall alkaline water splitting

Kinetics and oxidation of thiocarbohydrazide by hexacyanoferrate(III) in aqueous perchloric acid medium

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