Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs

Bolser, Donald C.; Aziz, Sultan M.; Chapman, Richard W.

doi:10.1016/0304-3940(91)90536-3

Cited by 36 publications

(16 citation statements)

References 13 publications

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“…This observation is in congruence with previous studies showing that reactive airway irritants activate influx of calcium ions in a subset of capsaicin-sensitive neurons (52). Second, TRPA1 is blocked by ruthenium red, known to antagonize irritant-induced bronchoconstriction (5, 18, 84). Third, capsaicin pre-treatment renders C-fibers insensitive to both mustard oil and chemical airway irritants (20, 53).…”

Section: Trpa1 – More Than Just Spicementioning

confidence: 99%

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

2008

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New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species and noxious constituents of smoke and smog, initiating irritation and airway reflex responses. Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough and airway inflammation in asthma, COPD and reactive airway dysfunction syndrome.

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Section: Trpa1 – More Than Just Spicementioning

confidence: 99%

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

2008

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“…Although seemingly varied in origin and chemical composition, many of these stimuli share common modes of action. For example, acids/ protons, capsaicin, resiniferetoxin and anandamide all act in part or entirely by activation of the ion channel/ receptor TRPV1 [3, 5-12]. Bradykinin and PGE2 may also act in part through TRPV1 activation [13-16].…”

Section: Chemical and Mechanical Stimuli That Initiate Coughingmentioning

confidence: 99%

Afferent Nerves Regulating the Cough Reflex: Mechanisms and Mediators of Cough in Disease

Canning

2010

Otolaryngologic Clinics of North America

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Bronchopulmonary C-fibers and acid-sensitive, capsaicin-insensitive mechanoreceptors innervating the larynx, trachea and large bronchi regulate the cough reflex. These vagal afferent nerves may interact centrally with sensory input arising from afferent nerves innervating the intrapulmonary airways or even extrapulmonary afferents such as those innervating the nasal mucosa and esophagus to produce chronic cough or enhanced cough responsiveness. The mechanisms of cough initiation in health and in disease are briefly described. Keywordscapsaicin; vagal; bradykinin; NMDA The cough reflex protects the airways and lungs from aspiration, inhaled irritants, particulates and pathogens and clears the air spaces of accumulated secretions. Studies in animals provide conclusive evidence that cough is initiated by activation of vagal afferent nerves. Precisely which afferent nerve subtypes regulate cough has been debated and reviewed elsewhere [1]. In this review, we describe the stimuli that initiate cough and the mechanisms by which these stimuli activate airway sensory nerves. These data are related to the known physiological properties of bronchopulmonary afferent nerve subtypes. The review concludes with a discussion of the potential interactions between afferent nerve subtypes and the possible mechanisms of altered cough reflexes in disease. Chemical and Mechanical Stimuli That Initiate CoughingMultiple chemical and mechanical stimuli have been shown to initiate coughing in human subjects and in animals [1][2][3][4]. Several of these stimuli, including capsaicin, citric acid, hypertonic saline and low chloride buffers/ solutions, are often used to evoke cough experimentally. Other stimuli known to initiate coughing in animals and in human subjects include particulate/ dust, mechanical/ vibratory stimulation of the airway mucosa larynx or chest wall, chemical irritants such as resiniferetoxin, cinnamaldehyde and allylisothiocyanate (AITC), and the autacoids bradykinin, anandamide and prostaglandin E2 (PGE2). Although

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“…capsaicin, acid). Acid (from gastric fluid/refluxate aspiration or airway acidification during disease), will also evoke coughing by TRPV1-dependent and independent (perhaps ASIC3-dependent) mechanisms [14,16,20,40,42,44,52,55-58]. These stimuli act on the capsaicin-sensitive C-fibres and/or the capsaicin-insensitive cough receptors.…”

Section: Why Study Central Processing Of Afferent Signaling Regulamentioning

confidence: 99%

Central regulation of the cough reflex: Therapeutic implications

Canning

2009

Pulmonary Pharmacology & Therapeutics

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In many species including humans, antagonists of NMDA-type glutamate receptors such as dextromethorphan, when used at sufficient doses, have been found to be relatively safe and effective antitussives. Similarly, now in five different species (guinea pigs, rabbits, cats, dogs and pigs), neurokinin receptor antagonists have also proven to be safe and effective antitussive agents. Both of these classes of drugs act centrally to prevent cough. A brief review of what is known about the central encoding of cough is presented, as are the advantages of centrally acting antitussives. Also discussed are new insights into cough and NMDA receptor signaling that may lead to the development of more effective antitussive agents with limited side effects and broad application in treating cough associated with a variety of aetiologies.

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Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs

Cited by 36 publications

References 13 publications

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

Afferent Nerves Regulating the Cough Reflex: Mechanisms and Mediators of Cough in Disease

Central regulation of the cough reflex: Therapeutic implications

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