Ruthenium, rhodium and iridium complexes containing diazafluorene derivative ligands: synthesis and biological studies

Nongpiur, Carley Giffert L.; Tripathi, Dulal Krishna; Poluri, Krishna Mohan; Rawat, Hemant; Kollipara, Mohan Rao

doi:10.1007/s12039-021-02004-2

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…The antimicrobial pictures illustrated in Figure 13 and Table 3 showed that the rhodium (III) complex exerted higher inhibitory effect on the tested strains than the ligand and other complexes cited in the literature, [48,49] which is due to the presence of the positive charge of the Rh (III) ion that is partially shared with the donor atoms of the ligand by delocalizing of p‐electrons over the whole chelation [50] …”

Section: Resultsmentioning

confidence: 96%

“…It should be noted that the size of the particles is a very important factor to understand the mechanism of particles penetration and absorption into bacterial cells. [46,47] The antimicrobial pictures illustrated in Figure 13 and Table 3 showed that the rhodium (III) complex exerted higher inhibitory effect on the tested strains than the ligand and other complexes cited in the literature, [48,49] which is due to the presence of the positive charge of the Rh (III) ion that is partially shared with the donor atoms of the ligand by delocalizing of p-electrons over the whole chelation. [50] The results of Table 3 revealed that the bacterial strains Micrococcus Luteus, Bacillus subtilis and aureus appear very sensitive to Rh (III) complex with an inhibition diameter varying between 28 and 27 mm.…”

Section: Antimicrobial Activity and Minimum Inhibitory Concentration ...mentioning

confidence: 94%

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Synthesis, Spectral Characterization, Antioxidant, Antimicrobial and Anticancer Activities of New Binuclear Copper and Rhodium Complexes

Ait‐Ramdane‐Terbouche

Elazara

Terbouche

et al. 2022

ChemistrySelect

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Two novel binuclear complexes of Cu (II) and Rh (III) with Bis [4‐hydroxy‐6‐methyl‐3‐{(1E)‐N‐[2‐(ethylamino) ethyl] ethanimidoyl}‐2H‐pyran‐2‐one] (L) were prepared and characterized by elemental analysis, electrospray ionization‐mass spectrometry (ESI‐MS), conductivity, nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT‐IR), ultraviolet‐visible spectrophotometry, fluorescence, thermogravimetric analysis ( TGA), scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDX) and cyclic voltammetry (CV). The spectral data indicate that the ligand binds the metal ions via the oxygen atom of the phenolic group, the nitrogen atoms of the azomethine and NH groups. These characterizations suggested the formation of binuclear complexes with octahedral geometry around each metal ion. For a better understanding of the response of complexes to biological activities, the stability constants, potential zeta and size of the complexes were determined. From the results, we can deduce that the complexes have more significant activities than their corresponding ligand. Moderate antioxidant activity recorded with both complexes, superior antibacterial and antifungal activities with Rh (III) complex with MIC value of 0.3125 mg. mL−1 and interesting anticancer activity towards Hep2 cells (IC50=13.77 μM) with Rh (III) and towards Hep2 (IC50=28.35 μM) and K562 cells (IC50=26.34 μM) with Cu (II) complex.

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Section: Resultsmentioning

confidence: 96%

Section: Antimicrobial Activity and Minimum Inhibitory Concentration ...mentioning

confidence: 94%

Synthesis, Spectral Characterization, Antioxidant, Antimicrobial and Anticancer Activities of New Binuclear Copper and Rhodium Complexes

Ait‐Ramdane‐Terbouche

Elazara

Terbouche

et al. 2022

ChemistrySelect

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“…The bacteria plates were kept in an incubator for 24 hours at 37°C. Later, the zone of inhibition was measured in millimetres (Millimeter) 26,27 .…”

Section: Antibacterial Activitymentioning

confidence: 99%

Characterization, antibacterial and anticancer study of silk fibroin hydrogel

Srivastava

Pandey²,

Kumar

et al. 2023

J. Drug Delivery Ther.

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Purpose: Protein-based hydrogels such as silk fibroin hydrogel, are used in tissue engineering and regenerative medicine applications as they showed striking characteristics like biocompatibility and offered various benefits as biomaterials. The current study sought to prepare silk fibroin hydrogel and characterise it in order to assess its antibacterial and anticancer activity. Methodology: Silk fibroin hydrogel was prepared and characterized by using different microscopy methods, namely Scanning Electron Microscopy (SEM), Phase Contrast Electron (PCM) microscopy, and foldscope analysis. Further, it was characterized through 1H-NMR analysis, Fourier Transform Infrared spectroscopy (FTIR) analysis, and swelling properties. A Current study also covers an antimicrobial and anticancer analysis of silk fibroin hydrogel by disk diffusion method and SRB (Sulforhodamine B) assay respectively. Results: The antibacterial study confirmed that SF hydrogel has a moderate antibacterial activity for Streptococcus mutans, and Salmonella typhi. Additionally, the SRB assay test showed that silk fibroin hydrogels had moderate anticancer activity against the human lung cancer cell line (A549). Conclusion: The current study unequivocally demonstrates that silk fibroin hydrogel has antibacterial and anti-cancerous properties, making it a suitable scaffold for future studies that seek to target a specific drug delivery site. Keywords: Silk fibroin; Swelling behaviour; Anticancer; Drug carrier; Wound healing

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“… 1 – 4 An important class of tetraamide macrocyclic (MacL 1-3 ) ligands are derived from the condensation of o-phenylenediamine with various aromatic dicarboxylic acids. Such type of ligands and their transition metal complexes have a wide-ranging field of pharmacological activities such as antitumor; 5 – 7 antibacterial; 8 – 10 antifungal; 11 , 12 antioxidant; 13 , 14 anti-inflammatory 15 and analgesics 16 activities. The formation of the macrocyclic ligands implicates the metal ion in the cavity of macrocyclic ligands and forms stable complexes, which makes the reactant groups in the desired conformation for the ring closer.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic Characterization, Biocidal evaluation Molecular Docking & DFT Investigation of 16-18 membered Macrocyclic Complexes of Cobalt (II)

et al. 2022

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Macrocyclic ligands (MacL 1 -MacL 3 ) and Co(II) complexes were synthesized via template condensation of o-phenylenediamine with various aromatic dicarboxylic acids. The elemental analysis, FT-IR, mass spectrometry, 1 H NMR, 13 C NMR, UV-vis, SEM analysis, powder X-ray diffraction, thermogravimetric (TG) analysis, electrochemical studies, and DFT analysis were used to characterize these synthesized ligands and their cobalt (II) complexes. TGA analysis to determine the stability and decomposition kinetic parameters. In element analysis, the percentage of different elements present and also the stoichiometry of compounds were confirmed. The proposed framework for tetraaza macrocyclic cobalt (II) complexes was supported by spectral analysis, which also revealed distorted octahedral geometry surrounding the central metal atom. The molecular structure of cobalt (II) complexes was also optimized theoretically, and their electronic or thermodynamic parameters were obtained from density functional theory (DFT). The synthesized ligands and their cobalt (II) complexes were tested against bacteria: Escherichia coli, Bacillus subtitles. Candida albicans were tested for antifungal properties. It was found that ligands and complexes show good antimicrobial results. Finally, using the Auto Dock VinaPyRx programme, molecular docking studies were used to evaluate the biological significance of the synthesized ligands to identify the probable and efficient binding mechanisms between the various ligands and the active site of the receptor protein. Graphical abstract Antimicrobial, DFT, and Docking representation of Cobalt (II) macrocyclic complexes Supplementary Information The online version contains supplementary material available at 10.1007/s12039-022-02109-2.

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Ruthenium, rhodium and iridium complexes containing diazafluorene derivative ligands: synthesis and biological studies

Cited by 15 publications

References 36 publications

Synthesis, Spectral Characterization, Antioxidant, Antimicrobial and Anticancer Activities of New Binuclear Copper and Rhodium Complexes

Synthesis, Spectral Characterization, Antioxidant, Antimicrobial and Anticancer Activities of New Binuclear Copper and Rhodium Complexes

Characterization, antibacterial and anticancer study of silk fibroin hydrogel

Synthesis, Spectroscopic Characterization, Biocidal evaluation Molecular Docking & DFT Investigation of 16-18 membered Macrocyclic Complexes of Cobalt (II)

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