Ruthenium(ii) polypyridyl complexes with visible light-enhanced anticancer activity and multimodal cell imaging

Abstract

Ruthenium(II) polypyridyl complexes have drawn growing attention due to their photophysical properties and anticancer activity. Herein we report four ruthenium(II) polypyridyl complexes ([(N^N)2RuII(L)]2+ (1 – 4, L = 4-anilinoquinazoline derivatives,...

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

“…Related ruthenium(II) quinazoline complexes (524) have also been developed as cancer theranostics. 976 Multimodal imaging with LSCM and SIMS shows that complex 524a primarily resides in the cytoplasm, while complex 524b predominantly accumulates in the nucleus. These complexes display enhanced cytotoxicity toward cancer cells upon irradiation due to 1 O 2 generation.…”

“…Remarkably, the complexes show high cytotoxic activity toward various cancer cell lines including A431, A549, HeLa, and MCF-7 cells, particularly demonstrating the selective inhibition of EGF-stimulated growth in MCF-7 cells. Related ruthenium(II) quinazoline complexes ( 524 ) have also been developed as cancer theranostics . Multimodal imaging with LSCM and SIMS shows that complex 524a primarily resides in the cytoplasm, while complex 524b predominantly accumulates in the nucleus.…”