Rutin inhibits carfilzomib-induced oxidative stress and inflammation via the NOS-mediated NF-κB signaling pathway

Al-Harbi, Naif O.; Imam, Faisal; Alharbi, Mohammed; Al‐Shabanah, Othman A.; Alotaibi, Moureq R.; Sobeai, Homood M. As; Afzal, Muhammad; Kazmi, Imran; Rikabi, Ammar Al

doi:10.1007/s10787-018-0550-5

Cited by 44 publications

(28 citation statements)

References 41 publications

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“…Rutin is a powerful free radical scavenger and has been reported to possess the ability to protect the liver from the adverse effects. 17,18,35 The pre-treatment with rutin has been reported to significantly reduce the activity of serum ALT, AST, and ALP and improve the histological signs of acute liver damage induced by CCl 4 33 and acetaminophen. 34 Abdel-Ghaffar et al 16 demonstrated that the activities of serum AST, ALT and ALP were remarkably elevated in isoniazid-treated rats and the animal group treated with rutin 1 hour before isoniazid administration caused a significant reduction in the activities of these enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…15 –17 The protective effect of rutin on carfilzomib-induced renal injury via the inhibition of oxidative stress and inflammation has been reported. 18 Further, the ameliorative effect of rutin against isoniazid-induced alterations in certain hematological and biochemical parameters of Albino rats has been reported. 19 The protective ability of rutin against cisplatin-induced hematotoxicity in tumor-bearing mice has also been demonstrated.…”

Section: Introductionmentioning

confidence: 96%

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Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities

Prasad

2020

Hum Exp Toxicol

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Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported by us that rutin and cisplatin in combination show better antitumor activity against murine ascites Dalton’s lymphoma. As cisplatin is given to cancer-bearing hosts only, the present study was undertaken to explore the histoprotective effect of rutin against some toxicities induced by cisplatin in tumor-bearing mice. Cisplatin treatment caused severe damages in tissue architecture such as degenerated hepatocytes with nuclear condensation and sinusoidal dilatation in the liver, glomerular deterioration, infiltration of cells, and tubular congestion in the kidney, and vacuolization of Sertoli cells or dense granules in the cytoplasm and damaged seminiferous tubules in the testes. In the rutin plus cisplatin combination-treated mice, all the abnormal tissue architectural features were decreased. Further, as compared to cisplatin treatment, combination treatment did not show any significant elevation in the liver functional biomarkers (serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) and renal functional biomarkers (serum urea and creatinine levels). The combination treatment reduced the sperm abnormalities also as compared to the cisplatin alone treatment. The in vitro hemolysis assay of red blood cells and scanning electron microscopy revealed that combination treatment lessened the cisplatin-induced hemolysis and abnormalities in RBCs. Thus, the present findings demonstrate that rutin has histoprotective ability against cisplatin-induced toxicities in tumor-bearing mice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities

Prasad

2020

Hum Exp Toxicol

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“…For example, quercetin (mol01, OB � 46.43%, DL � 0.28, HL � 14.40) could inhibit lipopolysaccharide-(LPS-) induced interleukin-(IL-) 6 production [39], TNF-α production, and IL-8 production [40,41] to exert anti-inflammatory effect. Besides, ursolic acid (mol17, OB � 16.77%, DL � 0.75, HL � 5.28) was reported to have human neutrophil elastase [44,45]. Above all, TCMSP-based systems pharmacology sifted out 41 potential bioactive compounds in Quyushengxin formula for treatment of UC.…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis

Yang

Shen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Objective. Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease whose treatment strategies remain unsatisfactory. This study aims to investigate the mechanisms of Quyushengxin formula acting on UC based on network pharmacology. Methods. Ingredients of the main herbs in Quyushengxin formula were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Absorption, distribution, metabolism, and excretion properties of all ingredients were evaluated for screening out candidate bioactive compounds in Quyushengxin formula. Weighted ensemble similarity algorithm was applied for predicting direct targets of bioactive ingredients. Functional enrichment analyses were performed for the targets. In addition, compound-target network, target-disease network, and target-pathway network were established via Cytoscape 3.6.0 software. Results. A total of 41 bioactive compounds in Quyushengxin formula were selected out from the TCMSP database. These bioactive compounds were predicted to target 94 potential proteins by weighted ensemble similarity algorithm. Functional analysis suggested these targets were closely related with inflammatory- and immune-related biological progresses. Furthermore, the results of compound-target network, target-disease network, and target-pathway network indicated that the therapeutic effects of Quyushengxin on UC may be achieved through the synergistic and additive effects. Conclusion. Quyushengxin may act on immune and inflammation-related targets to suppress UC progression in a synergistic and additive manner.

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“…In addition, some recent reports have also described that rutin was a protease inhibitor ( Al-Harbi et al, 2019 ). Ragunathan and Ravi have used molecular docking to suggest that rutin may be a potential inhibitor of protein ( Ragunathan and Ravi, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Rutin, A Natural Inhibitor of IGPD Protein, Partially Inhibits Biofilm Formation in Staphylococcus xylosus ATCC700404 in vitro and in vivo

Cui

Xing

et al. 2021

Front. Pharmacol.

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Staphylococcus xylosus (S. xylosus) has become an emerging opportunistic pathogen due to its strong biofilm formation ability. Simultaneously, the biofilm of bacteria plays an important role in antibiotic resistance and chronic infection. Here, we confirmed that rutin can effectively inhibit biofilm formation in S. xylosus, of which the inhibition mechanism involves its ability to interact with imidazole glycerol phosphate dehydratase (IGPD), a key enzyme in the process of biofilm formation. We designed experiments to target IGPD and inhibited its activities against S. xylosus. Our results indicated that the activity of IGPD and the amount of histidine decreased significantly under the condition of 0.8 mg/ml rutin. Moreover, the expression of IGPD mRNA (hisB) and IGPD protein was significantly down-regulated. Meanwhile, the results from molecular dynamic simulation and Bio-layer interferometry (BLI) technique showed that rutin could bind to IGPD strongly. Additionally, in vivo studies demonstrated that rutin treatment reduced inflammation and protect mice from acute mastitis caused by S. xylosus. In summary, our findings provide new insights into the treatment of biofilm mediated persistent infections and chronic bacterial infections. It could be helpful to design next generation antibiotics to against resistant bacteria.

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Rutin inhibits carfilzomib-induced oxidative stress and inflammation via the NOS-mediated NF-κB signaling pathway

Cited by 44 publications

References 41 publications

Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities

Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities

Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis

Rutin, A Natural Inhibitor of IGPD Protein, Partially Inhibits Biofilm Formation in Staphylococcus xylosus ATCC700404 in vitro and in vivo

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