Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model

Abstract

Abstract.Rutin has a variety of pharmacological actions, including radical reactivity, and protective activity against lipid peroxidation, viruses and acute pancreatitis; thus, it may be used as a treatment for many diseases. The present study aimed to investigate whether rutin inhibits coronary heart disease through extracellular signal-regulated kinase (ERK) 1/2 and Akt signaling in a porcine model. Male Chinese miniature pigs were randomly divided into four groups: A sham group, a coronary heart disease (CHD) model group, a group receiving 15 mg/kg rutin for 8 weeks following CHD modeling and a group receiving 45 mg/kg rutin for 8 weeks following CHD modeling. The results suggested that treatment with rutin suppressed the reduction in left ventricular ejection fraction and increase in systolic internal diameter that occurred in CHD model pigs. Rutin administration reduced the infarct size of the myocardium, attenuated LVEF, increased LVID and inhibited urine protein concentration, BUN and Scr expression levels in CHD model pigs. Results from western blot analysis demonstrated that in CHD pigs treated with 45 mg/kg rutin, the CHD-associated increases in transforming growth factor β1 and SMAD2 expression and reductions in phosphorylated (p)-ERK1/2 and p-Akt expression were attenuated. The present study suggests that rutin inhibits coronary heart disease through ERK1/2 and Akt signaling pathways in a porcine model.

Can rutin ameliorate aluminum phosphide-induced acute cardiac toxicity in adult albino rats?

“…The present study revealed that treatment with rutin after aluminium phosphide toxicity leading to a significant decrease in activity of SOD, with decreased levels of MDA, IL-6, and TNF-α compared to (AlP) intoxicated group but still significantly higher than normal control group, in association with significant increased level of GSH compared to (AlP) intoxicated group but still significantly lower than normal control group. These findings were supported by Lv et al (2018) who demonstrated that treatment with rutin significantly reversed the induced reductions of SOD, CAT, GST and GSH-Px activities in chronic heart disease in the pig. In addition, it has been explained that rutin has an anti-inflammatory activity due to modulation of apoptosis-associated proteins (Aruna et al, 2013).…”

Saussureae Involucratae Herba (Snow Lotus): Review of Chemical Compositions and Pharmacological Properties

“…TLR-4 and IL-6, in cultured H9C2 cells (Wu et al, 2018). Rutin exhibits similar pharmaceutical functions as that of acacetin (Korkmaz & Kolankaya, 2013;Lv et al, 2018). The pretreatment of rutin in rats dramatically attenuated cyclic guanosine monophosphate (cGMP) and NO level in serum and inhibited inducible nitric oxide synthase (iNOS) and 3nitrotyrosine (3-NT) formation in kidney (Korkmaz and Kolankaya, 2013).…”

Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant‐based bioactive compounds

“…Rutin (quercetin‐3‐rutinoside), also known as purple quercetin, vitamin P, sophorin, or rutoside, is a flavonoid which is present in black tea, buckwheat bran, green asparagus, passion flower, berries, and citrus fruits (Lv, Yao, Zhao, & Zhu, 2018; Patel & Patel, 2019; Salvamani et al., 2014). This compound was discovered in 1842 from the plant Fagopyrum esculentum (buckwheat).…”

“…This compound also possesses the activity of anti‐obesity through decreasing the oxidative stress, hepatosteatosis, and dyslipidemia (Mbaveng, Zhao, & Kuete, 2014; Salvamani et al., 2014). This bioactive compound shows positive role for the treatment of cerebrovascular and cardiovascular diseases (Lv et al., 2018). Rutin slows down the development of hypercholesterolemia and prevents atherosclerotic plaque formation in rabbits.…”