Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-κB pathway

Oluranti, Olufemi Idowu; Alabi, Babatunde; Michael, Olugbenga Samuel; Ojo, Alaba Olumide; Fatokun, Bosede P.

doi:10.1016/j.lfs.2021.119878

Cited by 44 publications

(16 citation statements)

References 58 publications

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“…Isochlorogenic acid has strong anti-atherosclerotic activity, which may protect endothelial cells and suppress vascular smooth muscle cell proliferation and migration [ 35 ]. Flavonoids have excellent protective abilities against cardiovascular disease, cancer, obesity, neurodegenerative diseases, diabetes, and several other diseases, especially rutin, which has been documented to offer potential cardioprotective effects in cardiac remodeling [ 36 , 37 ]. In addition, the leaves of A. quinata have been widely reported to be rich in phenolic and flavonoid compounds [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

Phenolic Profile and Fingerprint Analysis of Akebia quinata Leaves Extract with Endothelial Protective Activity

Cho

Kim

et al. 2022

Molecules

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In contrast to the stem and fruit of Akebia quinata, A. quinata leaves as a source rich in phenolic compounds with potentially beneficial pharmacological activities have been largely overlooked. To develop and use A. quinata leaves as a resource, we evaluated its potential as a cardiovascular-protective agent. Herein, we investigated the effects and potential mechanisms of A. quinata leaves extract on lipopolysaccharide (LPS)-induced inflammatory responses in human umbilical vein endothelial cells. We found that A. quinata leaves extract pretreatment of 10 μg/mL significantly attenuated LPS-induced protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1. Furthermore, this extract also suppressed LPS-induced phosphorylation of nuclear factor-κB p65. In order to elucidate the chemical profiles of the samples, the HPLC fingerprint was established, and prominent peaks were identified via HPLC–electrospray ionization–mass spectrometry. Multivariate statistical analyses, including hierarchical cluster analysis, principal component analysis, and partial least-squares discriminant analysis, were performed to evaluate the clustering of the samples. It was found that isochlorogenic acid C was a key marker for the classification of A. quinata leaves from the Gongju and Muju city in Korea. Collectively, this study not only suggested the potential of A. quinata leaves as a novel therapeutic candidate for inflammatory cardiovascular disease but also developed a quality control method for A. quinata leaves, which could help to expand the application of A. quinata.

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Section: Resultsmentioning

confidence: 99%

Phenolic Profile and Fingerprint Analysis of Akebia quinata Leaves Extract with Endothelial Protective Activity

Cho

Kim

et al. 2022

Molecules

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“…Inflammatory factors, oxidative stress, and mitochondrial dysfunction play significant roles in the pathogenesis of SIC ( Liu et al, 2017 ). Previous studies have shown that rutin reduces oxidative stress and alleviates myocardial damage in diabetic cardiomyopathy and coronary heart disease ( Huang et al, 2017 ; Imam et al, 2017 ; Lv et al, 2018 ; Oluranti et al, 2021 ). In our study, prophylactic administration of rutin before the onset of sepsis could attenuate cardiomyocyte apoptosis and alleviate cardiac dysfunction in septic mice, which illustrated the protective effect of rutin on SIC.…”

Section: Discussionmentioning

confidence: 99%

Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy

Meng

Liu

et al. 2022

Front. Physiol.

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Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopathy (SIC). In this study, we used male C57BL/6 mice and cecal ligation and puncture (CLP) surgery to establish the model of SIC. Rutin was precautionarily treated (50, 100, 200 mg/kg per day, 7 days) before CLP. The results showed that rutin pretreatment (100, 200 mg/kg per day, 7 days) reduced the mortality of murine sepsis. We chose the 100 mg/kg dose for further studies. Mice were pretreatment with rutin (100 mg/kg per day, 7 days) before subjected to CLP, and myocardial tissue and blood samples were collected 24 h after CLP. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment. The cardiomyocytes apoptosis and mitochondrial dysfunction were also alleviated with rutin pretreatment. In conclusion, this study confirmed the efficacy of rutin-enriched diet in the prophylaxis of cardiac apoptosis and cardiac injury induced by CLP in mouse model. It provides a potential new approach on SIC prophylaxis in sepsis.

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“…The longer lasting antioxidant effect via NRF‐2 is explained by the half‐lives of de novo synthesized antioxidant enzymes. Rutin treatment, for example, ameliorated cardiac oxido‐inflammatory dysregulation induced by plasticizers via NRF‐2 activation and nuclear factor kappa‐light‐chain‐enhancer of activated B cell (NF‐κB) suppression (Oluranti et al., 2021). NRF‐2 is a nuclear factor mainly responsible for protein and enzyme modulation against oxidative stress and inflammation (Speisky et al., 2022).…”

Section: Phenolic Compounds: What Is the Reason For So Much Interest?mentioning

confidence: 99%

Bioaccessibility of phenolic compounds using the standardized INFOGEST protocol: A narrative review

Camargo

Castro

2022

Comp Rev Food Sci Food Safe

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The INFOGEST protocol creation was a watershed for phenolic bioaccessibility studies. Because of this important initiative to standardize bioaccessibility studies, data comparisons between different laboratories are now expedited. It has been eight years since the INFOGEST protocol creation, and three from the latest update. However, the current status in terms of phenolic bioaccessibility and how far different laboratories are from reaching a consensus are still unrevealed.In this sense, this narrative review considered an evaluation of different studies that applied the INFOGEST protocol to investigate the bioaccessibility of phenolic compounds. The central objective was to compile the main findings and consensus and to identify possible gaps and future opportunities. This approach intends to further facilitate the use of this protocol by professionals in the field of food science and technology and related areas, generating a reflection on the actual level of standardization of the method. Despite the differences in phenolic compounds from diverse food matrices, and their peculiar behavior, some trends could be elucidated, in terms of phenolic release, stability, and/or transformation upon in vivo digestion. In contrast, there was no general consensus regarding sample preparation, how to report results and the form to calculate bioaccessibility, making it difficult to compare different studies. There is still a long road to effectively standardize the results obtained for phenolic bioaccessibility using the INFOGEST protocol, which is also an opportunity in terms of food analysis that can impact the food industry, especially for the development of nutraceuticals and functional foods.

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Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-κB pathway

Cited by 44 publications

References 58 publications

Phenolic Profile and Fingerprint Analysis of Akebia quinata Leaves Extract with Endothelial Protective Activity

Phenolic Profile and Fingerprint Analysis of Akebia quinata Leaves Extract with Endothelial Protective Activity

Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy

Bioaccessibility of phenolic compounds using the standardized INFOGEST protocol: A narrative review

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