Rutin protects against gamma-irradiation and malathion-induced oxidative stress and inflammation through regulation of mir-129-3p, mir-200C-3p, and mir-210 gene expressions in rats’ kidney

Ismail, Amel F.M.; Salem, A. A.; Eassawy, Mamdouh M. T.

doi:10.1007/s11356-023-27166-z

Cited by 7 publications

(3 citation statements)

References 76 publications

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“…In the current study, malathion significantly upregulated the expression of NFκβ in the kidney tissue and curcumin significantly ameliorated this elevation. This results in agreement with [39,40]; moreover, the same changes in the expression of TNF-α and curcumin reversed these changes, a finding similarly demonstrated by [41,42].…”

Section: Discussionsupporting

confidence: 87%

Curcumin Mitigates Malathion-Induced Renal Injury: Suppression of Apoptosis and Modulation of NF-κβ/TNF-α and Nrf2, and HO-1 Signaling

Eldesoqui,

Ahmed,

Abdel-Kareem

et al. 2023

Metabolites

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Malathion is one of the most used organophosphorus pesticides that is used for many reasons such as agriculture and industry. Human exposure to malathion may occur through various means, such as eating food that has been treated with it. Malathion not only increases oxidative stress but also decreases the antioxidant capacity. Curcumin is a powerful antioxidant with many pharmacological actions. Curcumin can act as a free radical scavenger and inhibit the activation and nuclear translocation of NF-κB. Curcumin could combat the lipid peroxidation and antioxidant depletion that trigger the apoptotic pathways. This study aims to examine the antioxidant, anti-inflammatory, and antiapoptotic effects of curcumin. Twenty-four Sprague Dawley rats were divided into four groups (six rats each): control, curcumin, malathion, and malathion + curcumin groups. At the assigned time, blood samples were used for the assessment of serum creatinine, and the kidneys were excised and washed; parts of them were used for the assessment of total oxidant status (TOS), oxidative stress index (OSI), the oxidative stress marker malondialdehyde (MDA), total antioxidant capacity (TAC), and glutathione (GSH) activity, other parts were fixed in formalin for further staining. Histopathological evaluation was performed for the fixed specimens after staining with H&E, sirus red, and the immunohistochemical staining for NF-κβ, TNF-α, Caspase-3, Nrf2, and HO-1. Curcumin significantly decreases the serum creatinine after malathion exposure and significantly restores the oxidant/antioxidant balance by increasing TAC and GSH and decreasing TOS, OSI, and MDA. Curcumin exerts its reno-protective effect and restores the histological architecture of the kidney by downregulating the immune expression of NF-κβ, TNF-α, and Caspase-3 and upregulating the expression of Nrf2 and HO-1. This study concluded that curcumin protects against nephrotoxicity caused by malathion by exerting its antioxidant, anti-inflammatory, and anti-apoptotic capabilities.

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Section: Discussionsupporting

confidence: 87%

Curcumin Mitigates Malathion-Induced Renal Injury: Suppression of Apoptosis and Modulation of NF-κβ/TNF-α and Nrf2, and HO-1 Signaling

Eldesoqui,

Ahmed,

Abdel-Kareem

et al. 2023

Metabolites

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“…127 Rutin inhibits γirradiation-induced oxidative stress and inflammation in rats by downregulating miR-200c-3p. 128 Resveratrol downregulates miR-200c-3p in breast cancer cells (Table 4). 129 4.1.7 | miR-21-5p miR-21-5p is upregulated by several natural products (Table 4).…”

Section: Mir-17-5pmentioning

confidence: 99%

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Chuang,

Yen,

Tang

et al. 2024

Environmental Toxicology

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Protein phosphatase 2A (PP2A), a heterotrimeric holoenzyme (scaffolding, catalytic, and regulatory subunits), regulates dephosphorylation for more than half of serine/threonine phosphosites and exhibits diverse cellular functions. Although several studies on natural products and miRNAs have emphasized their impacts on PP2A regulation, their connections lack systemic organization. Moreover, only part of the PP2A family has been investigated. This review focuses on the PP2A‐modulating effects of natural products and miRNAs' interactions with potential PP2A targets in cancer and non‐cancer cells. PP2A‐modulating natural products and miRNAs were retrieved through a literature search. Utilizing the miRDB database, potential PP2A targets of these PP2A‐modulating miRNAs for the whole set (17 members) of the PP2A family were retrieved. Finally, PP2A‐modulating natural products and miRNAs were linked via a literature search. This review provides systemic directions for assessing natural products and miRNAs relating to the PP2A‐modulating functions in cancer and disease treatments.

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“…The damaging properties of ionizing radiation have been contributed to the generation of reactive oxygen species (ROS) and reduction of the activity of antioxidant enzymes. Gamma-rays provokes destructive effects in the rats' kidney (Jit et al, 2022;Ismail et al, 2023). Moreover, the kidney is usually exposed to high doses of radiation in the treatment of some cancers in abdominal region radiotherapy (Azmoonfar et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Eugenol Mitigates γ-rays-induced Acute Renal Destructive Impacts in Rats

Elkady,

Ebrahim,

El khouly

2023

Egypt. J. Rad.Sci.

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A CUTE renal injury is a common and hazardous distress of γ-rays' exposure. The aim of the current study is to explore the role of eugenol on γ-rays-induced acute kidney lesions in rats. The rats were separated into four groups (n=6). The control group received saline for two weeks. The eugenol group received i.p. 20 mg/kg Eugenol for two weeks. The γ-rays group was pretreated with saline for a week, then whole-body exposed to 8 Gy γ-rays and saline treatment continued for another week. The rats in γ-rays+ eugenol group received Eugenol for a week preirradiation, then were exposed to γ-rays and eugenol treatment continued for another week. The blood and kidney samples were collected for histopathological and biochemical investigations. It was observed that exposure to γ-rays induced atrophy of glomeruli with increasing capsular space, expanded renal tubules and congested inter tubular blood vessels. Histological changes were accompanied by significant decreases in the level of antioxidants: reduced glutathione content (GSH), and superoxide dismutase (SOD), and catalase (CAT) activities with a significant increase of malondialdehyde (MDA; end-product of lipid peroxidation), indicating oxidative stress. Significant increases in the levels of inflammatory markers, tumor necrosis factor-alpha (TNF-α) and interleukin-1 Beta (IL-1β) levels were recorded also. Kidney damage was substantiated by significant increases in urea, creatinine, lactate dehydrogenase (LDH), γ-glutamyltransferase (γGT), and disturbance of electrolytes balance; elevated sodium (Na + ), and decreased potassium (K + ). Eugenol treatment has significantly improved histological damage oxidative stress and inflammatory-biomarkers, which was accompanied by significant amelioration of kidney functions. It could be concluded that eugenol may alleviate acute kidney injury resulting from γ-rays exposure through its antioxidant and anti-inflammatory properties.

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Rutin protects against gamma-irradiation and malathion-induced oxidative stress and inflammation through regulation of mir-129-3p, mir-200C-3p, and mir-210 gene expressions in rats’ kidney

Cited by 7 publications

References 76 publications

Curcumin Mitigates Malathion-Induced Renal Injury: Suppression of Apoptosis and Modulation of NF-κβ/TNF-α and Nrf2, and HO-1 Signaling

Curcumin Mitigates Malathion-Induced Renal Injury: Suppression of Apoptosis and Modulation of NF-κβ/TNF-α and Nrf2, and HO-1 Signaling

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Eugenol Mitigates γ-rays-induced Acute Renal Destructive Impacts in Rats

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