RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction

Guazzi, Marco; Dixon, Debra; Labate, Valentina; Beussink‐Nelson, Lauren; Bandera, Francesco; Cuttica, Michael J.; Shah, Sanjiv J.

doi:10.1016/j.jcmg.2016.12.024

Cited by 345 publications

(318 citation statements)

References 23 publications

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“…18 Other studies have confirmed the prognostic significance of TAPSE/PASP parameter in patients with heart failure. 19,20 TAPSE is a well-known, quick, and easily measurable echocardiographic parameter that does not require sophis- Table 2. whereas in patients with TRPG/TAPSE ≤4.5 mmHg/mm the frequency of the CE was significantly lower (4, 2.1%, P=0.0005).…”

Section: Discussionmentioning

confidence: 99%

Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE)　― A Novel Parameter for Stepwise Echocardiographic Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism ―

Ciurzyński

Kurnicka

Lichodziejewska

et al. 2018

Circ J

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which is estimated at more than 15%. 4,5 Fortunately most APE patients are hemodynamically stable at admission but the early mortality risk is different in this population. Risk stratification of non-high-risk APE patients is based on clinical presentation, cardiac laboratory biomarkers, and signs of right ventricular (RV) dysfunction on echocardiography or computed tomography. 4,6 Low-risk patients require a short hospital stay and can be early discharged home or even treated as outpatients. 7 Intermediate-risk subjects comprise a very heterogeneous group in which the early mortality ranges between 2% and 15%. 4 More of A cute pulmonary embolism (APE) is the most serious clinical presentation of venous thromboembolism (VTE). According to registries and hospital discharge databases of unselected patients with APE and VTE, 30-day all-cause mortality rates are between 9% and 10%. 1-3 According to the recent European Society of Cardiology (ESC) guidelines on the diagnosis and treatment of APE patients, clinical classification of the severity of an episode of APE is based on the estimated 30-day APErelated mortality risk. 4 Patients with cardiogenic shock caused by APE comprise a high-risk group for early death, Background: Patients with intermediate-risk acute pulmonary embolism (APE) are a heterogeneous group with an early mortality rate of 2-15%. The tricuspid annulus plane systolic excursion (TAPSE) and tricuspid regurgitation peak gradient (TRPG) can be used for risk stratification, so we analyzed the prognostic value of a new echo parameter (TRPG/TAPSE) for prediction of APE-related 30-day death or need for rescue thrombolysis in initially normotensive APE patients.

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Section: Discussionmentioning

confidence: 99%

Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE)　― A Novel Parameter for Stepwise Echocardiographic Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism ―

Ciurzyński

Kurnicka

Lichodziejewska

et al. 2018

Circ J

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“…A flattening VO 2 trajectory emerged as associated with older age, higher plasma NT‐proBNP level, lower LVEF, and a more unfavourable response of several CPET variables. In addition, in the flattening group, the TAPSE/PASP ratio, a measure of RV‐PV uncoupling, was significantly lower discriminating a relevant haemodynamic feature that has been highlighted in a number of recent reports . Remarkably, this background applies to all HF phenotypes, irrespective of LVEF.…”

Section: Discussionmentioning

confidence: 60%

A flattening oxygen consumption trajectory phenotypes disease severity and poor prognosis in patients with heart failure with reduced, mid‐range, and preserved ejection fraction

Popović

Arena

Guazzi

2018

European J of Heart Fail

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“…Lastly prior studies have demonstrated RV size and function to be a critical prognostic indicator in pulmonary arterial hypertension (PAH) and congenital heart disease. 7,8,9,10 Despite the role of the RV in stratification of prognosis, non-invasive evaluation of the RV remains challenging due to several key anatomic factors.…”

Section: Right Ventricle Backgroundmentioning

confidence: 99%

Multimodality Imaging of the Right Ventricle

Abouzeid

Shah

Johri

et al. 2017

Curr Treat Options Cardio Med

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Opinion Statement Right ventricular (RV) structure and function is clinically important in a wide range of conditions. While conventional echocardiography (echo) methods are widely used, its limitations in RV assessment due its complex geometry are well recognized. New applications of traditional echo methods as well as emerging echo techniques including 3-dimensional (3D) echo and speckle tracking strain have the potential to overcome limitations of conventional echo though widespread clinical use remains to be seen. Volumetric methods using cardiac magnetic resonance (CMR) and computed tomography (CT) provide accurate assessment of RV function without geometric assumptions. In addition, tissue characterization imaging for myocardial scar and fat using CMR and CT provides important information regarding the RV beyond structure and function alone and has clinical applications for diagnosis and prognosis in a broad range of pathologies. Limitations also exist for these two advanced modalities including availability and patient suitability for CMR and need for contrast and radiation exposure for CT. The complementary role of each modality for the RV as well as emerging evidence for the use of each imaging method in diagnosis and management of RV pathologies are outlined in this study.

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RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction

Cited by 345 publications

References 23 publications

Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE)　― A Novel Parameter for Stepwise Echocardiographic Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism ―

Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE)　― A Novel Parameter for Stepwise Echocardiographic Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism ―

A flattening oxygen consumption trajectory phenotypes disease severity and poor prognosis in patients with heart failure with reduced, mid‐range, and preserved ejection fraction

Multimodality Imaging of the Right Ventricle

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RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction

Cited by 345 publications

References 23 publications

Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE) ― A Novel Parameter for Stepwise Echocardiographic Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism ―

Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE) ― A Novel Parameter for Stepwise Echocardiographic Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism ―

A flattening oxygen consumption trajectory phenotypes disease severity and poor prognosis in patients with heart failure with reduced, mid‐range, and preserved ejection fraction

Multimodality Imaging of the Right Ventricle

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Product

Resources

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Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE)　― A Novel Parameter for Stepwise Echocardiographic Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism ―

Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE)　― A Novel Parameter for Stepwise Echocardiographic Risk Stratification in Normotensive Patients With Acute Pulmonary Embolism ―