RV/TLC% ratio: alternative criteria of normality

Herranz, A. Díez

doi:10.1183/09031936.95.08101812

Cited by 11 publications

(8 citation statements)

References 1 publication

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“…[65,66] The ratio of elevated Residual Volume over Total Lung Capacity (RV/TLC) could be used to reveal air trapping in these patients similar to patients with scleroderma and obstructive lung disease. [67,68] In combination with CT evidence of air trapping, a specific finding of BOS[69], these parameters may be able to identify patients with early obstruction even in the presence of severe restrictive diseases of myositis or sclerotic GVHD. In a recent publication, we proposed that these criteria be modified to capture patients with earlier disease for interventions with minimal risk, reserving more stringent criteria for diagnosis and therapies with greater risks (Table 1)[70].…”

Section: Clinical Assessment Of Bos After Hctmentioning

confidence: 99%

Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation—An Increasingly Recognized Manifestation of Chronic Graft-versus-Host Disease

Chien

Duncan

Williams

et al. 2010

Biology of Blood and Marrow Transplantation

168

167

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Bronchiolitis obliterans syndrome (BOS) is a progressive, insidious, and often fatal lung allo-reaction that can occur following allogeneic hematopoietic stem cell transplantation (HCT) or allogeneic lung transplantation. Current estimates in the literature suggest that approximately 2–3% of all allogeneic HCT recipients and 6% of patients who develop chronic GVHD will develop this syndrome. However, based on newer data it is likely that the true incidence of BOS is higher. Unfortunately, the survival and treatment of patients with BOS after HCT has not improved over the last 20 years. Attempts at clinical trials have been hindered by the lack of uniform diagnostic criteria and inability to detect the syndrome at a reversible stage in its natural history. Recently, the NIH consensus project for criteria in chronic GVHD has made recommendations regarding the diagnosis of BOS and monitoring of lung disease among long term survivors. Although a rare and poorly understood manifestation of chronic GVHD, BOS occurs commonly after lung transplantation and is similar in pathology, clinical presentation, radiographic presentation, and presumed immunologic pathogenesis. This review describes the current understanding of the epidemiology and pathogenesis of BOS and presents information on evaluations and therapies for patients with BOS after HCT.

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Section: Clinical Assessment Of Bos After Hctmentioning

confidence: 99%

Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation—An Increasingly Recognized Manifestation of Chronic Graft-versus-Host Disease

Chien

Duncan

Williams

et al. 2010

Biology of Blood and Marrow Transplantation

168

167

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“…Elevated residual volume may reveal air trapping by pulmonary function tests, although it is limited by the fact that this parameter is influenced by the estimated total lung capacity and not directly measured. It has been proposed that the ratio of residual volume to total lung capacity be considered for identification of air trapping by pulmonary function tests, 51 and while this has yet to be tested in the population with bronchiolitis obliterans syndrome, the ratio of residual volume to total lung capacity has been shown to be elevated in patients with scleroderma and obstructive lung disease. 52 Air trapping also is denoted by a mosaic pattern on CT scans.…”

Section: Diagnostic Criteria For Bronchiolitis Obliterans Syndromementioning

confidence: 99%

Bronchiolitis Obliterans After Allogeneic Hematopoietic Stem Cell Transplantation

Williams

Chien²,

Gladwin³

et al. 2009

JAMA

191

189

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With improvements in supportive care, both long-term survival following allogeneic hematopoietic stem cell transplantations (HSCTs) and the indications for this procedure have increased. As a result, the number of patients living with long-term toxic effects due to HSCT has increased. A once rare condition of the donor immune cells attacking healthy host tissues, termed chronic graftvs-host disease, has become a more common phenomenon. When chronic graftvs-host disease affects the lung tissue, bronchiolitis obliterans syndrome ensues. Recent data suggest that bronchiolitis obliterans syndrome may affect up to 6% of HSCT recipients and dramatically alters

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“…The predicted values for spirometry and for lung volumes were selected. 15,16 Small airway dysfunction was defined by the following criteria: 1) the ratio of RV/TLC ≥ 40%, 10 or 2) the post -bronchodilator (post-BD) value of R 5 -R 20 ≥ 0.075 kPa.L -1 s. 11…”

Section: Introductionmentioning

confidence: 99%

Prevalence of small airways dysfunction in asthma with- and without-fixed airflow obstruction and chronic obstructive pulmonary disease

Pornsuriyasak

Khiawwan

Rattanasiri

et al. 2021

Asian Pac J Allergy Immunol

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Background: Small airways dysfunction (SAD) is not uncommon in asthma without fixed airflow obstruction (FAO). Objectives:We aimed to determine if SAD in non-FAO asthma is different from FAO-asthma and COPD.Methods: Cases of obstructive airway diseases who underwent spirometry, plethysmography, and impulse oscillometry [resistance at 5 Hz (R 5 ) and at 20 Hz (R 20 ), peripheral resistance (R 5 -R 20 ), and reactance area (AX)] were reviewed, and classified as; 1) COPD, 2) FAO-asthma, and 3) non-FAO asthma. FAO was defined as post-bronchodilator (post-BD) FEV 1 / FVC < 0.7. SAD was considered if 1) RV/TLC ≥ 40%, or 2) post-BD R 5 -R 20 ≥ 0.075 kPa.L -1 s.Results: A total of 73 patients (22 COPD, 24 FAO-asthma, and 27 non-FAO asthma) were analyzed. RV/TLC ratio was higher in FAO-asthma and COPD (45 ± 5% and 42 ± 8%) than in non-FAO asthma (32 ± 8%), p < 0.001. Post-BD values of R 5 -R 20 and AX (median; range) were higher in FAO-asthma (0.17; 0.08, 0.47, 13.24; 6.52, 82.11) than in non-FAO asthma (0.11; 0.03, 0.23, 8.63; 2.40, 22.02), p = 0.007 and p = 0.017, respectively. The prevalence of SAD among diagnosis group by RV/TLC criterion was different (95%, 59%, and 15% in FAO-asthma, COPD, and non-FAO asthma, p < 0.001), but those were not observed by R 5 -R 20 criterion (95%, 68%, and 77%, p = 0.052). Conclusion:SAD in non-FAO asthma was less prevalent than FAO-asthma and COPD.

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RV/TLC% ratio: alternative criteria of normality

Cited by 11 publications

References 1 publication

Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation—An Increasingly Recognized Manifestation of Chronic Graft-versus-Host Disease

Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation—An Increasingly Recognized Manifestation of Chronic Graft-versus-Host Disease

Bronchiolitis Obliterans After Allogeneic Hematopoietic Stem Cell Transplantation

Prevalence of small airways dysfunction in asthma with- and without-fixed airflow obstruction and chronic obstructive pulmonary disease

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