RvD1 treatment during primary infection modulates memory response increasing viral load during respiratory viral reinfection

Freitas, Deise do Nascimento de; Franceschina, Caroline Marinho; Muller, Douglas; Hilario, Gabriel; Gassen, Rodrigo Benedetti; Fazolo, Tiago; Kaminski, Valéria de Lima; Maito, Fábio Luiz Dal Moro; Antunes, Krist Helen; Zanin, Rafael Fernandes; Rodrigues, Luiz Carlos; Souza, Ana Paula Duarte de

doi:10.1016/j.imbio.2021.152151

Cited by 2 publications

(4 citation statements)

References 69 publications

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“…-Decreases post-infection lung eosinophils in vivo in models of RSV [80]. -Decreases polymorphonucler leukocyte recruitment and chemokine, cytokine levels in IRI [81].…”

Section: Resolvin D5 (Rvd5)mentioning

confidence: 99%

“…During viral infections, intranasal-administrated PD1 decreased post-infection lung eosinophils and attenuated the respiratory syncytial virus (RSV)-induced suppression of interferon-lambda in a mouse’s lung in vivo. PD1 also increased interferon-lambda expression in human bronchial epithelial cells in vitro [ 80 ]. RvD1 increased the frequency of memory CD8 + T cells and during reinfection presented a high viral load in the lung and lower antibody response in the serum, suggesting that RvD1 modulates the expression and phenotype of memory CD8 + T cells [ 80 ].…”

Section: Therapeutic Effectiveness Of Spms In Respiratory Inflammatio...mentioning

confidence: 99%

“…PD1 also increased interferon-lambda expression in human bronchial epithelial cells in vitro [ 80 ]. RvD1 increased the frequency of memory CD8 + T cells and during reinfection presented a high viral load in the lung and lower antibody response in the serum, suggesting that RvD1 modulates the expression and phenotype of memory CD8 + T cells [ 80 ]. Similarly, in RSV inflammation, activation of the MaR1-LGR6 axis reduced IL-13 secretion from ILC2 cells and CD4 T helper, while inhibiting FoxP3-expressing Tregs, highlighting the protective role of the MaR1-LGR6 signaling axis and leading to decreased viral burden, pathogen-induced inflammation, and restoration of airway function ( Figure 2 ) [ 41 ].…”

Section: Therapeutic Effectiveness Of Spms In Respiratory Inflammatio...mentioning

confidence: 99%

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Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer

Babar,

Nassar,

Nie

et al. 2024

Metabolites

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Acute inflammation is the body’s first defense in response to pathogens or injury that is partially governed by a novel genus of endogenous lipid mediators that orchestrate the resolution of inflammation, coined specialized pro-resolving mediators (SPMs). SPMs, derived from omega-3-polyunstaturated fatty acids (PUFAs), include the eicosapentaenoic acid-derived and docosahexaenoic acid-derived Resolvins, Protectins, and Maresins. Herein, we review their biosynthesis, structural characteristics, and therapeutic effectiveness in various diseases such as ischemia, viral infections, periodontitis, neuroinflammatory diseases, cystic fibrosis, lung inflammation, herpes virus, and cancer, especially focusing on therapeutic effectiveness in respiratory inflammation and ischemia-related injuries. Resolvins are sub-nanomolar potent agonists that accelerate the resolution of inflammation by reducing excessive neutrophil infiltration, stimulating macrophage functions including phagocytosis, efferocytosis, and tissue repair. In addition to regulating neutrophils and macrophages, Resolvins control dendritic cell migration and T cell responses, and they also reduce the pro-inflammatory cytokines, proliferation, and metastasis of cancer cells. Importantly, several lines of evidence have demonstrated that Resolvins reduce tumor progression in melanoma, oral squamous cell carcinoma, lung cancer, and liver cancer. In addition, Resolvins enhance tumor cell debris clearance by macrophages in the tumor’s microenvironment. Resolvins, with their unique stereochemical structure, receptors, and biosynthetic pathways, provide a novel therapeutical approach to activating resolution mechanisms during cancer progression.

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“…-Decreases post-infection lung eosinophils in vivo in models of RSV [80]. -Decreases polymorphonucler leukocyte recruitment and chemokine, cytokine levels in IRI [81].…”

Section: Resolvin D5 (Rvd5)mentioning

confidence: 99%

Section: Therapeutic Effectiveness Of Spms In Respiratory Inflammatio...mentioning

confidence: 99%

Section: Therapeutic Effectiveness Of Spms In Respiratory Inflammatio...mentioning

confidence: 99%

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Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer

Babar,

Nassar,

Nie

et al. 2024

Metabolites

View full text Add to dashboard Cite

show abstract

“…In the context of RSV infection, different subtypes of resolvins may have varying effects on the host. For instance, treatment with RvD1 was found to be associated with increased viral loads in the lungs and a lower antibody response upon reinfection in mice (de Freitas et al, 2021). Conversely, RvE1 was shown to be beneficial against RSV: RvE1 treatment restored the M2 phenotype of macrophages that were infected with RSV (Shirey et al, 2014).…”

Section: Resolvins and Viral Infectionsmentioning

confidence: 99%

Resolution pharmacology and the treatment of infectious diseases

Costa,

Resende,

Melo

et al. 2024

British J Pharmacology

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Inflammation is elicited by the host in response to microbes, and is believed to be essential for protection against infection. However, we have previously hypothesized that excessive or misplaced inflammation may be a major contributor to tissue dysfunction and death associated with viral and bacterial infections. The resolutive phase of inflammation is a necessary condition to achieve homeostasis after acute inflammation. It is possible that targeting inflammation resolution may be beneficial for the host during infection. In this review, we summarize the evidence demonstrating the expression, roles and effects of the best described pro‐resolving molecules in the context of bacterial and viral infections. Pro‐resolving molecules play a pivotal role in modulating a spectrum of pathways associated with tissue inflammation and damage during both viral and bacterial infections. These molecules offer a blend of anti‐inflammatory, pro‐resolving and sometimes anti‐infective benefits, all the while circumventing the undesired and immune‐suppressive unwanted effects associated with glucocorticoids. Whether these beneficial effects will translate into benefits to patients clearly deserve further investigation.

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RvD1 treatment during primary infection modulates memory response increasing viral load during respiratory viral reinfection

Cited by 2 publications

References 69 publications

Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer

Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer

Resolution pharmacology and the treatment of infectious diseases

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