2008
DOI: 10.1038/cmi.2008.41
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Rwdd1, a Thymus Aging Related Molecule, Is a New Member of the Intrinsically Unstructured Protein Family

Abstract: We had previously identified a novel protein termed Rwdd1 whose expression in thymus is decreased in aged or oxidatively stressed mice. In the present study, we found that Rwdd1 expressed in both prokaryotic and eukaryotic cells showed a slower migration rate on SDS-PAGE gel. In addition, Rwdd1 was more sensitive to proteinase proteolysis. Furthermore, being a highly acidic protein which contains an RWD domain, Rwdd1 shared a high level of sequence similarity with Gir2, a member of the intrinsically unstructur… Show more

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Cited by 11 publications
(4 citation statements)
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“…As found for Yih1/IMPACT, Gir2 associates with Gcn1 via an N‐terminal RWD domain and inhibits Gcn2 activation when overexpressed; interestingly it also associates with the ribosome [20]. Human Gir2 orthologues were identified [28], again demonstrating the high evolutionary conservation of a regulatory protein involved in controlling Gcn2, and simultaneously underscoring the fact that yeast can be used as model system for fully understanding the molecular mechanisms underlying the regulation of Gcn2.…”
Section: Discussionmentioning
confidence: 92%
“…As found for Yih1/IMPACT, Gir2 associates with Gcn1 via an N‐terminal RWD domain and inhibits Gcn2 activation when overexpressed; interestingly it also associates with the ribosome [20]. Human Gir2 orthologues were identified [28], again demonstrating the high evolutionary conservation of a regulatory protein involved in controlling Gcn2, and simultaneously underscoring the fact that yeast can be used as model system for fully understanding the molecular mechanisms underlying the regulation of Gcn2.…”
Section: Discussionmentioning
confidence: 92%
“…Within the upland breeds, many genes found in the selected regions had functions related to cell stress and metabolism (Table 3). The most highly supported by DCMS, RWDD1, encodes a transcription factor related to sulfide metabolism in metozoans (Kang et al, 2008;Li et al, 2018). HSPA5 also responds to cell stress mechanisms by promoting protein refolding in the endoplasmic reticulum in cancers or virally-infected cells (Booth et al, 2015).…”
Section: Candidate Genes In Welsh Upland Sheep Breedsmentioning
confidence: 99%
“…Therefore, we speculate that DRG2 associates with mRNA and thereby plays roles in transcription, mRNA splicing, and translation. RWDD1, which is known to interact with DRG2, was reported to interact with androgen receptors and to act as a coactivator of androgen-dependent transcription [28][29][30]. If RWDD1 can function as a coactivator of other nuclear receptors including ERα/β, it would raise the possibility that DRG2 and RWDD1 function cooperatively in the transcription of ERα target genes.…”
Section: Possible Functions Of Drg2 and Rwdd1 In Regulating Epigeneticsmentioning
confidence: 99%