Ryanodane diterpenes from two Erythroxylum species

Barreiros, Marizeth L.; David, Juceni P.; David, Jorge; Lopes, Lucia Maria Xavier; Sá, Matheus Santos de; Costa, José Fernando Oliveira; Almeida, Mara Zélia de; Queiroz, Luciano Paganucci de; Santana, Antônio Euzébio Goulart

doi:10.1016/j.phytochem.2007.05.007

Cited by 22 publications

(15 citation statements)

References 16 publications

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“…Parte do extrato (100,0 g) foi dissolvido em metanol-água (7:3) e, em seguida, submetido a sucessivas partições líquido/líquido com hexano, diclorometano e acetato de etila em funil de 150 mL utilizando 4L de cada solvente, obtendo, assim, as frações hexânica (10,0 g), diclorometano (4,4 g) e acetato de etila (25,3 g). Uma alí-quota da fase acetato de etila (6,0 g) foi submetida à cromatografia líquida de média pressão, utilizando sílica gel como adsorvente e acetato de etila e metanol em gradiente de 100% de acetato de etila a 50% de metanol durante 8 Os meios de cultura utilizados para as análises foram: o BHI (Brain Heart Infusion -HIMEDIA), 8 g para 1L, para as linhagens de Streptococcus e o LB (Luria Bertani) preparado com 5 g de extrato de levedura (DIFCO), 10 g de triptona (DIFCO), 10 g de NaCl (VETEC) para 1L, para as demais linhagens. Todos os reagentes utilizados apresentavam grau de pureza P.A.…”

Section: Procedimento Para Obtenção Dos Extratos E Isolamento Dos Conunclassified

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FLAVONOID GLYCOSIDES FROMErythroxylum pulchrumA. St.-Hil. (Erythroxylaceae)

Albuquerque¹,

Tavares²,

Oliveira³

et al. 2014

Química Nova

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Section: Procedimento Para Obtenção Dos Extratos E Isolamento Dos Conunclassified

“…6 Estudos realizados com Erythroxylum spp. coletadas no Nordeste brasileiro descreveram a presença de alcaloides tropanos com atividade citotóxica e inibidores da acetilcolinesterase, 6,7 diterpenos, [8][9][10] e flavonoides.…”

Section: Introductionunclassified

FLAVONOID GLYCOSIDES FROMErythroxylum pulchrumA. St.-Hil. (Erythroxylaceae)

Albuquerque¹,

Tavares²,

Oliveira³

et al. 2014

Química Nova

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“…The clerodane diterpenoids from Clerodendron infortunatum was found to act against the cotton bollworm, Helicoverpa armigera (Abbaszadeh et al, 2014). Otherwise, ryanodane diterpenes from two Erythroxylum species were reported earlier to exhibit an insecticidal activity against Aedes aegypti larvae, which is the main vector of dengue, Zika, of chikungunya and yellow fever (Barreiros et al, 2007).…”

Section: Trogopterus Xanthipesmentioning

confidence: 99%

Therapeutic Potential of Essential Oils Focusing on Diterpenes

et al. 2016

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Among all plant derivates, essential oils (EOs) have gained the attention of many scientists. Diterpenes, a family of components present in some EO, are becoming a milestone in the EOs world. The goal of this review is to describe a scenario of diterpenes taking into health-consumption deportment. Previous studies revealed that diterpenes have antioxidant, antimicrobial, antiviral, antiprotozoal, cytotoxic, anticancer, antigenotoxic, antimutagenic, chemopreventive, antiinflammatory, antinociceptive, immunostimulatory, organoprotective, antidiabetic, lipid-lowering, antiallergic, antiplatelet, antithrombotic, and antitoxin activities. In conclusion, diterpenes may be an immense featuring concern in pharmaceutical consumption from a drug discovery point of view. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Erythroxylaceae is a family of flowering trees with tropical and subtropical distribution, and four genera comprise such families: Aneulophus Benth, Erythroxylum P. Br, Nectaropetalum Engl., and Pinacopodium . Erythroxylum is considered the largest genus, with 230 species [13,14,15,16,17,18]. In Brazil, these species occur in two biomes: “restinga” (typical vegetation on quartzite, sandy, nutrient-poor parent materials over the Brazilian coast) and “cerrado” (savannas of central Brazil).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of the Plant Extracts of Erythroxylum sp. against Toxic Effects Induced by the Venom of Lachesis muta Snake

et al. 2016

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Snake venoms are composed of a complex mixture of active proteins that induce toxic effects, such as edema, hemorrhage, and death. Lachesis muta has the highest lethality indices in Brazil. In most cases, antivenom fails to neutralize local effects, leading to disabilities in victims. Thus, alternative treatments are under investigation, and plant extracts are promising candidates. The objective of this work was to investigate the ability of crude extracts, fractions, or isolated products of Erythroxylum ovalifolium and Erythroxylum subsessile to neutralize some toxic effects of L. muta venom. All samples were mixed with L. muta venom, then in vivo (hemorrhage and edema) and in vitro (proteolysis, coagulation, and hemolysis) assays were performed. Overall, crude extracts or fractions of Erythroxylum spp. inhibited (20%-100%) toxic effects of the venom, but products achieved an inhibition of 4%-30%. However, when venom was injected into mice before the plant extracts, hemorrhage and edema were not inhibited by the samples. On the other hand, an inhibition of 5%-40% was obtained when extracts or products were given before venom injection. These results indicate that the extracts or products of Erythroxylum spp. could be a promising source of molecules able to treat local toxic effects of envenomation by L. muta venom, aiding in the development of new strategies for antivenom treatment.

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Ryanodane diterpenes from two Erythroxylum species

Cited by 22 publications

References 16 publications

FLAVONOID GLYCOSIDES FROMErythroxylum pulchrumA. St.-Hil. (Erythroxylaceae)

FLAVONOID GLYCOSIDES FROMErythroxylum pulchrumA. St.-Hil. (Erythroxylaceae)

Therapeutic Potential of Essential Oils Focusing on Diterpenes

Protective Effect of the Plant Extracts of Erythroxylum sp. against Toxic Effects Induced by the Venom of Lachesis muta Snake

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