Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

Lahm, George P.; Stevenson, Thomas M.; Selby, Thomas P.; Freudenberger, John H.; Cordova, Daniel; Flexner, Lindsey; Bellin, Cheryl A.; Dubas, Christine M.; Smith, Ben K.; Hughes, Kenneth A.; Hollingshaus, J. Gary; Clark, Christopher E; Benner, Eric A.

doi:10.1016/j.bmcl.2007.09.012

Cited by 487 publications

(302 citation statements)

References 12 publications

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“…Chlorantraniliprole and thiamethoxam represent two systemic insecticides used in seed treatments, belonging to two different groups, diamides and neonicotinoids, respectively. Chlorantraniliprole acts as a ryanodine receptor modulator to block insect muscle contraction (Lahm et al 2007). In contrast, thiamethoxam is a neonicotinoid insecticide that targets nicotinic acetylcholine receptors in the central nervous system of insects, causing overstimulation at low concentrations, and receptor blockage, paralysis and death at higher concentrations (Tomizawa and Casida 2005).…”

mentioning

confidence: 99%

Non-target effects of chlorantraniliprole and thiamethoxam on Chrysoperla carnea when employed as sunflower seed treatments

et al. 2014

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confidence: 99%

Non-target effects of chlorantraniliprole and thiamethoxam on Chrysoperla carnea when employed as sunflower seed treatments

et al. 2014

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“…The selectivity observed for chlorantraniliprole might be because chlorantraniliprole acts mainly after ingestion (LAHM et al, 2007), therefore limiting its action to phytophagous insects. Chlorantraniliprole acts on the nervous system of an organism by activating the receptors of ryanodine by releasing calcium from the sarcoplasmic reticulum of muscle cells causing paralysis and death of the insect (CORDOVA et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Effect of increasing rate of insecticides on its selectivity for Trichogramma pretiosum Riley (Hymenoptera: Trichogrammatidae)

Grande

Braz

Bueno

et al. 2018

SCA

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The present study evaluated the effect of different rates of chlorantraniliprole, chlorantraniliprole + lambda-cyhalothrin, spinosad, and chlorfenapyr on their selectivity for the pupae and adults of Trichogramma pretiosum. The negative effect of majority of the insecticides tested on most of the parasitoids was directly proportional to the rate of the insecticide applied. Chlorantraniliprole at a rate of 10 g a.i. ha -1 was classified as harmless (class 1) to both pupae and adults of the parasitoid. The effect of chlorantraniliprole at a rate of 20 to 50 g a.i. ha -1 varied from harmless (class 1) to slightly harmful (class 2) to the adults of T. pretiosum. Chlorantraniliprole 10 + lambda-cyhalothrin at 5 g a.i. ha -1 was classified as harmless (class 1) to the pupae and moderately harmful (class 3) to the adults of T. pretiosum. On the contrary, the highest rate of chlorantraniliprole 50 + lambda-cyhalothrin tested (i.e., 25 g a.i. ha -1 ) was classified as slightly harmful (class 2) to the pupae and harmful (class 4) to the adults of the parasitoid. Similarly, increasing the application rate of spinosad and chlorfenapyr also exhibited an increase in toxicity. Spinosad at a rate of 24 g a.i. ha -1 was classified as slightly harmful (class 2) and harmless (class 1) to the pupae and adults of T. pretiosum, respectively. Spinosad at 96 g a.i. ha -1 was classified as both moderately harmful (class 3) and harmful (class 4) to the pupae of the parasitoid. Chlorfenapyr at a rate of 192 g a.i. ha -1 was classified as both slightly harmful (class 2) and moderately harmful (class 3) to the pupae of T. pretiosum, whereas chlorfenapyr at 336 g a.i. ha -1 was categorized as slightly harmful (class 3) and harmful (class 4) to the pupae. These results indicate that an increase in the rate of insecticide affected T. pretiosum negatively. Therefore, higher insecticide rates should only be adopted when strictly necessary to control the target pest, because they might compromise the biological pest control process in the field. ResumoO presente estudo avaliou o efeito de diferentes taxas de clorantraniliprole, clorantraniliprole + lambdacialotrina, espinosade, e clorfenapir na seletividade para as pupas e adultos de Trichogramma pretiosum. O efeito negativo da maioria dos inseticidas testados nos parasitoides foi diretamente proporcional à dose do inseticida aplicado. O clorantraniliprole na dose de 10 g a.i. ha -1 foi classificado como seletivo (classe 1) para pupas e adultos do parasitoide. O efeito do clorantraniliprole na dose de 20 a 50 g a.i. ha -1 variou de seletivo (classe 1) a levemente prejudicial (classe 2) aos adultos de T. pretiosum. Clorantraniliprole 10 + lambda-cialotrina a 5 g a.i. ha -1 foi classificado como seletivo (classe 1) para as pupas e moderadamente prejudicial (classe 3) aos adultos de T. pretiosum. Ao contrário, a dose mais alta de clorantraniliprole 50 + lambda-cialotrina testada (isto é, 25 g a.i. ha -1 ) foi classificada como moderadamente prejudicial (classe 3) para as pupas e nociva (cla...

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“…The ryanodine receptors (RyR), which regulates calcium ion channel in insect nerve synpase, has represented one of the attractive biological target for pest control strategies. 1 The commercial chlorantraniliprole (A), 2,3 which has a typical anthranilic diamide structure, was developed by DuPont Co. and exhibited exceptional insecticidal activity on a broad range of Lepidoptera, Coleoptera, Diptera and Isoptera. 4 The anthranilic diamide structure has been characteristic to chlorantraniliprole, yet the insecticidal activity of simpler structures that eliminate the aliphatic amide moiety has been little reported.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Insecticidal Evaluation of Novel Pyrazolecarboxamides Containing Cyano Substituted N‐Pyridylpyrazole

Liu

Xiong

et al. 2010

Chin. J. Chem.

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12 novel pyrazolecarboxamides containing cyano substituted N-pyridylpyrazole were synthesized, and their structures were characterized by 1 H NMR and HRMS techniques. Their evaluated insecticidal activities against oriental armyworm (Mythimna separata) indicated that the cyano-containing pyrazolecarboxamides exhibited moderate insecticidal activities. Compounds 6i and 6k showed comparable higher activity than corresponding anthranilic diamide 6m.

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Rynaxypyr™: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

Cited by 487 publications

References 12 publications

Non-target effects of chlorantraniliprole and thiamethoxam on Chrysoperla carnea when employed as sunflower seed treatments

Non-target effects of chlorantraniliprole and thiamethoxam on Chrysoperla carnea when employed as sunflower seed treatments

Effect of increasing rate of insecticides on its selectivity for Trichogramma pretiosum Riley (Hymenoptera: Trichogrammatidae)

Design, Synthesis and Insecticidal Evaluation of Novel Pyrazolecarboxamides Containing Cyano Substituted N‐Pyridylpyrazole

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