S-100 Protein and Neuron Specific Enolase (NSE) Expression by Chordomas in Relation to the Composition of their Stromal Mucosubstances

Karabela-Bouropoulou, V.; Kontogeorgos, George; Papamichales, G.; Milas, Ch.; Roessner, Albert; Vollmer, Ekkehard; Grundmann, E.

doi:10.1016/s0344-0338(88)80118-3

Cited by 11 publications

(8 citation statements)

References 17 publications

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“…Immunohistochemical techniques have been used to analyze chordomas of animals [ 2 , 4 , 7 , 10 , 26 ] and humans [ 12 , 13 , 17 , 20 , 23 , 28 ]. Cytokeratins are almost constantly expressed in neoplastic cells in ferrets, dogs, cats and rats ( Table 3 ) [ 2 , 4 , 7 , 10 , 18 , 26 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…NSE is expressed in chordomas of ferrets (91%) and rats (100%) [ 4 , 26 , 32 ], and S100 protein is expressed in chordomas of ferrets (77%), dogs (100%), cats (100%) and rats (78%) [ 2 , 4 , 7 , 10 , 26 , 32 ]. The expression of S100 protein and NSE in human chordomas is related to the composition of stromal glycosaminoglycans (chondroitin) [ 13 ]. The expression of NSE and S100 protein in the present study indicated the presence of glycosaminoglycans, such as chondroitin and hyaluronic acid, in the myxoid stroma and neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

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Histochemical and immunohistochemical characterization of chordoma in ferrets

Yui

Ohmachi²,

Matsuda

et al. 2015

The Journal of Veterinary Medical Science

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Chordomas of the tip of the tail in 6 ferrets were examined using histopathological, histochemical and immunohistochemical procedures. Histopathologically, round neoplastic cells containing numerous cytoplasmic vacuoles of varying sizes, categorized as “physaliphorous cells”, were observed in the amorphous eosinophilic or pale basophilic myxoid stroma. Physaliphorous cells were arranged in lobules and in a “chordoid” or “cobblestone” manner. The neoplasms were diagnosed as benign chordoma without local invasion and metastasis. Histochemically, the cytoplasm of small neoplastic cells was positive for periodic acid-Schiff stain and alcian blue (AB) pH 2.5 and pH 1.0 stains, but negative for hyaluronidase digestion-AB pH 2.5 stain. All neoplastic cells were strongly stained with colloidal ion, negative for high iron diamine AB pH 2.5 and toluidine blue pH 2.5 stains, and positive for Mayer’s mucicarmine stain. Immunohistochemistry using antibodies directed against low-molecular-weight cytokeratins (CK18, CK19 and CK20), vimentin and mucin core protein (MUC5AC) revealed that neoplastic cells had both epithelial and mesenchymal elements. The expression of low-molecular-weight cytokeratins suggests that neoplastic cells acquired the properties of glandular epithelial cells and produced epithelial mucus. Furthermore, the expression of cytokeratins, vimentin, S100 protein, brachyury and epithelial membrane antigen indicates that the neoplasms were equivalent to the classic type of human chordoma. Therefore, immunohistochemistry using these antibodies can be useful for the characterization of ferret chordoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histochemical and immunohistochemical characterization of chordoma in ferrets

Yui

Ohmachi²,

Matsuda

et al. 2015

The Journal of Veterinary Medical Science

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“…In a previous study, the positivity of S-100 in chordomas was found to be related to the presence of stromal glycosaminoglycans of the chondroitin sulfate type. 8 In addition, S-100 has been reported in an everincreasing number of neoplasms of unrelated histogenesis. Neuron-specific enolase was found in cells with features of high metabolic activity.…”

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confidence: 99%

A Case of Coccygeal Chondroid Chordoma in a Cat: Morphological and Immunohistochemical Features

et al. 2008

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Abstract. In August 2007, a 4-year-old, intact, female Domestic Shorthair cat was examined for a mass on the tip of the tail. Histological examination performed after apical caudectomy revealed a neoplasm affecting the distal part of the last coccygeal vertebra. The neoplasm consisted of lobules of physaliferous cells surrounding cartilaginous tissue and a central core of trabecular bone. A diagnosis of chondroid chordoma was made based on histomorphological features and immunohistochemical results. Chondroid chordoma has been previously reported in humans, rats, ferrets, and mink. To the authors' knowledge, chondroid chordoma has not been reported in cats. Neither recurrence nor metastasis was reported 7 months after surgery.

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“…Immunohistochemical staining is positive for pancytokeratins, low molecular weight keratins and epithelial membrane antigen 18 . S100 positivity may relate to stromal glycosaminoglycans of the chondroitin sulphate A and C type and is not essential for diagnosis when other features are present 19 …”

Section: Discussionmentioning

confidence: 99%

“…18 S100 positivity may relate to stromal glycosaminoglycans of the chondroitin sulphate A and C type and is not essential for diagnosis when other features are present. 19…”

Section: Pathogenesismentioning

confidence: 99%

Cervical chordoma presenting as retropharyngeal mass and dysphonia: Case report and literature review

Singh¹,

Soo²,

Cruz

et al. 2007

Australasian Radiology

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Chordoma is a rare primary bone tumour that presents with signs and symptoms of local compression and myelopathy. A case of C4 chordoma with unusual clinical and imaging features is presented. The diagnosis of chordoma requires clinical, radiological and pathological correlation. Clinical features may include laryngeal symptoms arising from distortion of local anatomy. Characteristic tumour appearance and distribution on imaging plays a key role in diagnosis and management of this slow growing tumour with potential for major surgical morbidity.

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S-100 Protein and Neuron Specific Enolase (NSE) Expression by Chordomas in Relation to the Composition of their Stromal Mucosubstances

Cited by 11 publications

References 17 publications

Histochemical and immunohistochemical characterization of chordoma in ferrets

Histochemical and immunohistochemical characterization of chordoma in ferrets

A Case of Coccygeal Chondroid Chordoma in a Cat: Morphological and Immunohistochemical Features

Cervical chordoma presenting as retropharyngeal mass and dysphonia: Case report and literature review

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