2004
DOI: 10.1016/s0924-977x(04)90083-1
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S.4.05 Reduced N-acetyl aspartate levels in the temporal cortex of rats reared in isolation

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Cited by 2 publications
(2 citation statements)
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“…168 It has also been shown to be abnormal in key brain areas in several psychiatric illnesses including schizophrenia, 169 depression, 170 and anxiety disorders, 4,[171][172][173] although the directionality of NAA in these diseases has been more variable than in the neurodegenerative disorders. We and others have shown, for example, decreased NAA in the superior temporal gyrus of patients with schizophrenia, 174 decreased NAA in the anterior cingulate of monkeys exposed to early rearing stress, 175 reduced NAA concentrations in the temporal cortex of rats reared in isolation, 176 and increased NAA in the dorsolateral prefrontal cortex of patients with GAD. 4 Importantly, NAA appears to be vulnerable to psychosocial stress.…”
Section: Neuroimaging Of Glutamatergic Function In Anxiety Disordersmentioning
confidence: 60%
“…168 It has also been shown to be abnormal in key brain areas in several psychiatric illnesses including schizophrenia, 169 depression, 170 and anxiety disorders, 4,[171][172][173] although the directionality of NAA in these diseases has been more variable than in the neurodegenerative disorders. We and others have shown, for example, decreased NAA in the superior temporal gyrus of patients with schizophrenia, 174 decreased NAA in the anterior cingulate of monkeys exposed to early rearing stress, 175 reduced NAA concentrations in the temporal cortex of rats reared in isolation, 176 and increased NAA in the dorsolateral prefrontal cortex of patients with GAD. 4 Importantly, NAA appears to be vulnerable to psychosocial stress.…”
Section: Neuroimaging Of Glutamatergic Function In Anxiety Disordersmentioning
confidence: 60%
“…Levels of the presynaptic protein CDCrel-1, which has been associated with schizophrenia [332], are reduced in the striatum of isolation-reared rats, but increased in the hippocampus [333], as are synaptophysin levels and the high correlation between synaptophysin and CDCrel-1 levels observed in socially reared rats is reduced in isolation-reared rats. Levels of n-acetylaspartate, reductions of which are also observed in schizophrenia [334], are also reduced in the temporal cortex of isolated rats [335]. …”
Section: Deprivation Of Social Play In Rodentsmentioning
confidence: 99%