S-Adenosyl-l-methionine: Beyond the universal methyl group donor

Roje, Sanja

doi:10.1016/j.phytochem.2006.04.019

Cited by 374 publications

(279 citation statements)

References 147 publications

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“…SAM is an important metabolite as it serves as a major donor of methyl groups in numerous reactions involving methylation of DNA, RNA, proteins and metabolites [4][5][6] . Thus, in addition to its essential role in polyamine synthesis, AdoMetDC may also influence methylation reactions by affecting SAM availability.…”

Section: Adometdc Catalyses the Decarboxylation Of S-adenosylmethionimentioning

confidence: 99%

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

Yordanova

Loughran

Zhdanov

et al. 2018

Nature

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Section: Adometdc Catalyses the Decarboxylation Of S-adenosylmethionimentioning

confidence: 99%

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

Yordanova

Loughran

Zhdanov

et al. 2018

Nature

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“…1). SAM, as a primary methyl group donor, also regulates important processes such as chlorophyll and cell wall synthesis (Roje, 2006). For these reasons, many studies were performed to assess the factors that regulate Met metabolism and its accumulation (Hesse et al, 2004;Amir et al, 2012;Galili and Amir, 2013).…”

mentioning

confidence: 99%

Seed-Specific Expression of a Feedback-Insensitive Form of CYSTATHIONINE-γ-SYNTHASE in Arabidopsis Stimulates Metabolic and Transcriptomic Responses Associated with Desiccation Stress

et al. 2014

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and Tel-Hai College, Upper Galilee 11016, Israel (R.A.) With an aim to elucidate novel metabolic and transcriptional interactions associated with methionine (Met) metabolism in seeds, we have produced transgenic Arabidopsis (Arabidopsis thaliana) seeds expressing a feedback-insensitive form of CYSTATHIONINEg-SYNTHASE, a key enzyme of Met synthesis. Metabolic profiling of these seeds revealed that, in addition to higher levels of Met, the levels of many other amino acids were elevated. The most pronounced changes were the higher levels of stress-related amino acids (isoleucine, leucine, valine, and proline), sugars, intermediates of the tricarboxylic acid cycle, and polyamines and lower levels of polyols, cysteine, and glutathione. These changes reflect stress responses and an altered mitochondrial energy metabolism. The transgenic seeds also had higher contents of total proteins and starch but lower water contents. In accordance with the metabolic profiles, microarray analysis identified a strong induction of genes involved in defense mechanisms against osmotic and drought conditions, including those mediated by the signaling cascades of ethylene and abscisic acid. These changes imply that stronger desiccation processes occur during seed development. The expression levels of transcripts controlling the levels of Met, sugars, and tricarboxylic acid cycle metabolites were also significantly elevated. Germination assays showed that the transgenic seeds had higher germination rates under salt and osmotic stresses and in the presence of ethylene substrate and abscisic acid. However, under oxidative conditions, the transgenic seeds displayed much lower germination rates. Altogether, the data provide new insights on the factors regulating Met metabolism in Arabidopsis seeds and on the mechanisms by which elevated Met levels affect seed composition and behavior.

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“…1998). As a donor for methyl groups, methionine regulates essential cellular processes, such as cell division, cell wall synthesis, chlorophyll synthesis, and membrane synthesis through SAM (Roje 2006). Furthermore, SAM is the source of polyamines, in particular spermidine and spermine, which play crucial roles in many aspects of plant growth, including cell proliferation and differentiation, apoptosis, homeostasis, and gene expression (Kuznesov and Shevyakova 2007;Pang et al 2007).…”

Section: Introductionmentioning

confidence: 99%

In vitro rooting and biochemical parameters in the cherry rootstocks CAB-6P and Gisela 6 using L-methionine

Sarropoulou¹,

Dimassi-Theriou²,

Therios³

2013

Turk J Agric For

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S-Adenosyl-l-methionine: Beyond the universal methyl group donor

Cited by 374 publications

References 147 publications

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

Seed-Specific Expression of a Feedback-Insensitive Form of CYSTATHIONINE-γ-SYNTHASE in Arabidopsis Stimulates Metabolic and Transcriptomic Responses Associated with Desiccation Stress

In vitro rooting and biochemical parameters in the cherry rootstocks CAB-6P and Gisela 6 using L-methionine

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