S-Adenosylmethionine in a Neuroblastoma

Lyon, G. Marshall

doi:10.1203/00006450-197108000-00004

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1974

1985

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Cited by 3 publications

(2 citation statements)

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“…L-Methionine (9) and L-ethionine (10) both compete in a similar manner with the substrate histidine in either the A or the L transport systems. Similar effects can be noted for L-cysteine (12) and DL-homocysteine (11).…”

supporting

confidence: 75%

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Synthetic sulfur-containing amino acids. Inhibition of transport systems in S37 ascites tumor cells

Lewis¹,

Inloes²,

Hes³

et al. 1978

J. Med. Chem.

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The preparation of a series of synthetic sulfur-containing amino acids is described. These compounds included heterocyclic analogues of L-cysteine, DL-norcysteine, and DL-homocysteine. The amino acids were assessed for their ability to inhibit the neutral amino acid transport systems of the Sarcoma 37 ascites tumor cell and their inhibitions were compared with those of L-methionine and L-ethionine. Transport studies indicated that the amino acids synthesized were capable of inhibiting the uptake of [3H]-L-histidine in the S37 cell.

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supporting

confidence: 75%

“…The amino acid 11 was the most potent inhibitor of the alicyclic analogues studied in our laboratories. As can be seen in Table I, the L system is most effectively inhibited when substrate concentration ratios are taken into consideration.…”

mentioning

confidence: 92%