S-allylcysteine improves ischemia/reperfusion alteration on cardiac function, antioxidant, and mitochondrial permeability

Aziz, N. F H; Ramalingam, Anand; Latip, Jalifah; Zainalabidin, Satirah

doi:10.1016/j.lfs.2021.119080

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…EGCG has also been shown to inhibit LDH activity, leading to reduced lactate production and cardioprotective effects ( Eng et al, 2018 ). Additionally, S-allylcysteine treatment was shown to improve cardiac function in rats while decreasing oxidative stress and mitochondrial permeability ( Aziz et al, 2021 ). Allicin, found in garlic, demonstrated a significant vasodilating effect on coronary arteries, leading to increased coronary blood flow in the experimental group both before ischemia and during reperfusion.…”

Section: Ldh Inhibitors: Types Mechanisms and Therapeutic Applicationsmentioning

confidence: 99%

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Han,

Lee,

Park

et al. 2023

Front. Pharmacol.

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Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases. Targeting LDH has emerged as a vital approach in drug discovery, leading to the identification of LDH inhibitors among natural compounds, such as polyphenols, alkaloids, and terpenoids. These compounds demonstrate therapeutic potential against LDH-related diseases, including anti-cancer effects. However, challenges concerning limited bioavailability, poor solubility, and potential toxicity must be addressed. Combining natural compounds with LDH inhibitors has led to promising outcomes in preclinical studies. This review highlights the promise of natural compounds as LDH inhibitors for treating cancer, cardiovascular, and neurodegenerative diseases.

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Section: Ldh Inhibitors: Types Mechanisms and Therapeutic Applicationsmentioning

confidence: 99%

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Han,

Lee,

Park

et al. 2023

Front. Pharmacol.

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“…With a considerable reduction in LDH leakage and retained mitochondrial permeability, SAC‐repercussed hearts demonstrated the avoidance of worsening cardiac function following I/R induction. They also increased glutathione and glutathione reductase levels in a dose‐dependent manner (Aziz, Ramalingam, Latip, & Zainalabidin, 2021).…”

Section: Bioactivity Of Black Garlicmentioning

confidence: 99%

Black garlic: A review of its biological significance

Javed

Ahmed

2022

Journal of Food Biochemistry

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Garlic has been used as a vegetable since ancient times, and it has proved versatility in preventative and therapeutic approaches. The use of garlic in the food business was restricted because of its strong flavor and harsh odor. Fermentation and different chemical processes, such as the Millard reaction and microbial fermentation, produce black garlic. Thermal processing at precise temperatures and relative humidity enhanced flavor and prolonged shelf life. This article holds the most up‐to‐date information about the resourcefulness and complexity of garlic processing and its biological implications. Recent findings have shown proof of the superior qualitative features and physical activities of black garlic. Before introducing this to the food market, researchers must conduct high‐quality research to evaluate the changes of metabolites to achieve largest antioxidant, anticancer, anti‐obesity, anti‐inflammatory, immune, hepatoprotective, cardioprotective, neuroprotective, and anti‐allergenic performance. Researchers should evaluate the quality, marketing, post‐harvest handling, and consumption practices of black garlic.

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“…Treatment with exogenous or endogenous antioxidants has been examined and validated as a supplemental therapy for DM. Allium plants such as garlic ( Allium sativum , Liliaceae) produce S-allyl cysteine (SAC; S-hydrocarbyl-L-cysteine) (Figure 1) (NCBI, 2022a), an organosulfur amino acid (Aziz, Ramalingam, Latip, & Zainalabidin, 2021). Aged garlic extract contains more durable and bioavailable water-soluble organosulfur components like S-allylmercapto-L-cysteine (SAMC), SAC, ajoene, alliin and allicin (Asdaq et al ., 2021; Baseggio Conrado, Fanelli, McGuire, & Ibbotson, 2021; Rais, Ved, Ahmad, & Parveen, 2021).…”

Section: Introductionmentioning

confidence: 99%

S-allyl cysteine and Taurine attenuate diabetic nephropathy in rats via the inhibition of oxidative stress and recovering histopathological changes

Rais

Ved²,

Rahim³

et al. 2023

AGJSR

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PurposeRenal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.Design/methodology/approachExperimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.FindingsThe following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.Originality/valueSAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.

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S-allylcysteine improves ischemia/reperfusion alteration on cardiac function, antioxidant, and mitochondrial permeability

Cited by 8 publications

References 25 publications

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Black garlic: A review of its biological significance

S-allyl cysteine and Taurine attenuate diabetic nephropathy in rats via the inhibition of oxidative stress and recovering histopathological changes

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