S-allylcysteine therapy reduces adverse cardiac remodelling after myocardial infarction in a rat model

Zainalabidin, Satirah; Ramalingam, Anand; Mohamed, Siti Fatimah Azaharah; Ali, Shafreena Shaukat; Latip, Jalifah; Yap, Wei Boon

doi:10.1016/j.jff.2019.103750

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…Direct damage exerted by these superoxides causes cardiac dysfunction by inducing apoptotic and inflammatory responses, thereby stimulating the cardiac remodelling process [ 97 ]. The cardiac remodelling process is a compensatory response against structural and functional damage that include activation of matrix metalloproteinase (MMP) to alter the architecture of the extracellular matrix and modulation of signal transduction pathways that initiate cardiomyocyte hypertrophy in order to preserve normal functions of the heart [ 98 , 99 ]. However, uncontrolled and excessive cardiac remodelling in persistent diabetic conditions further disturbs the ability of the heart to contract and relax efficiently, resulting in the development of diastolic and systolic dysfunctions along with the appearance of prominent cardiac structural changes [ 100 ].…”

Section: Effects Of Activation Of Pkc-mapk Pathways To Cardiovascular...mentioning

confidence: 99%

The Role of PKC-MAPK Signalling Pathways in the Development of Hyperglycemia-Induced Cardiovascular Complications

Jubaidi

Zainalabidin

Taib

et al. 2022

IJMS

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Cardiovascular disease is the most common cause of death among diabetic patients worldwide. Hence, cardiovascular wellbeing in diabetic patients requires utmost importance in disease management. Recent studies have demonstrated that protein kinase C activation plays a vital role in the development of cardiovascular complications via its activation of mitogen-activated protein kinase (MAPK) cascades, also known as PKC-MAPK pathways. In fact, persistent hyperglycaemia in diabetic conditions contribute to preserved PKC activation mediated by excessive production of diacylglycerol (DAG) and oxidative stress. PKC-MAPK pathways are involved in several cellular responses, including enhancing oxidative stress and activating signalling pathways that lead to uncontrolled cardiac and vascular remodelling and their subsequent dysfunction. In this review, we discuss the recent discovery on the role of PKC-MAPK pathways, the mechanisms involved in the development and progression of diabetic cardiovascular complications, and their potential as therapeutic targets for cardiovascular management in diabetic patients.

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Section: Effects Of Activation Of Pkc-mapk Pathways To Cardiovascular...mentioning

confidence: 99%

The Role of PKC-MAPK Signalling Pathways in the Development of Hyperglycemia-Induced Cardiovascular Complications

Jubaidi

Zainalabidin

Taib

et al. 2022

IJMS

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“…These components exert a relaxation effect on coronary arteries during ischemic reperfusion (IR) (Najman, Sadowska, & Hallmann, 2020). It also reduces IR‐induced myocardial stress due to the enhancement of antioxidants activity in the heart (Zainalabidin et al, 2020). In CHD patients, BG therapy reduced N‐terminal pro‐body BNP levels and inhibited neuroendocrine activation (Liu, Zhang, Cong, & Wen, 2018).…”

Section: Bioactivity Of Black Garlicmentioning

confidence: 99%

Black garlic: A review of its biological significance

Javed

Ahmed

2022

Journal of Food Biochemistry

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Garlic has been used as a vegetable since ancient times, and it has proved versatility in preventative and therapeutic approaches. The use of garlic in the food business was restricted because of its strong flavor and harsh odor. Fermentation and different chemical processes, such as the Millard reaction and microbial fermentation, produce black garlic. Thermal processing at precise temperatures and relative humidity enhanced flavor and prolonged shelf life. This article holds the most up‐to‐date information about the resourcefulness and complexity of garlic processing and its biological implications. Recent findings have shown proof of the superior qualitative features and physical activities of black garlic. Before introducing this to the food market, researchers must conduct high‐quality research to evaluate the changes of metabolites to achieve largest antioxidant, anticancer, anti‐obesity, anti‐inflammatory, immune, hepatoprotective, cardioprotective, neuroprotective, and anti‐allergenic performance. Researchers should evaluate the quality, marketing, post‐harvest handling, and consumption practices of black garlic.

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“…S-allylcysteine: An organosulfur compound found in garlic, it can inhibit the proliferation of cardiac fibroblasts and reduce collagen deposition in the heart, which may help prevent cardiac fibrosis [148]. A study by Zainalabidin et al also showed that S-allylcysteine reduces adverse cardiac remodeling after myocardial infarction in a rat model and also limits cardiac fibrosis in rats [149].…”

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confidence: 99%

Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

Majid

Hassan

Hoque

et al. 2023

JCDD

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Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure. Despite significant research efforts in characterizing and identifying key molecular mechanisms associated with myocardial fibrosis, effective treatment for this condition is still out of sight. In this regard, bioactive compounds have emerged as potential therapeutic antifibrotic agents due to their anti-inflammatory and antioxidant properties. These compounds exhibit the ability to modulate fibrogenic processes by inhibiting the production of extracellular matrix proteins involved in fibroblast to myofibroblast differentiation, or by promoting their breakdown. Extensive investigation of these bioactive compounds offers new possibilities for preventing or reducing cardiac fibrosis and its detrimental consequences. This comprehensive review aims to provide a thorough overview of the mechanisms underlying cardiac fibrosis, address the limitations of current treatment strategies, and specifically explore the potential of bioactive compounds as therapeutic interventions for the treatment and/or prevention of cardiac fibrosis.

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S-allylcysteine therapy reduces adverse cardiac remodelling after myocardial infarction in a rat model

Cited by 7 publications

References 27 publications

The Role of PKC-MAPK Signalling Pathways in the Development of Hyperglycemia-Induced Cardiovascular Complications

The Role of PKC-MAPK Signalling Pathways in the Development of Hyperglycemia-Induced Cardiovascular Complications

Black garlic: A review of its biological significance

Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

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