S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways

Zhu, Xiaosong; Jiang, Xiaoyan; Li, Ang; Sun, Yehuan; Liu, Yan; Sun, Xiao; Feng, Xiuli; Li, Siying; Zhao, Zhongxi

doi:10.1016/j.bbrc.2017.06.107

Cited by 28 publications

(17 citation statements)

References 22 publications

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“…Fresh garlic extract was suggested to suppress cancer cell proliferation, which was related to increased endoplasmic reticulum stress (Petrovic et al, ). S‐allylmercaptocysteine, one of the water‐soluble organosulfur garlic derivatives, was suggested to suppress the growth of gastric cancer in in vivo conditions because of its effect on antiproliferation, apoptosis induction, and the regulation of the MAPK and PI3K/Akt pathways (Zhu et al, ). Moreover, several compounds extracted from allium vegetables, such as allyl‐thiosulfinates, have shown inhibitory effects on the growth of Helicobacter pylori (Canizares et al, ; Sivam, Lampe, Ulness, Swanzy, & Potter, ).…”

Section: Discussionmentioning

confidence: 99%

“…Fresh garlic extract was suggested to suppress cancer cell proliferation, which was related to increased endoplasmic reticulum stress (Petrovic et al, 2018). S-allylmercaptocysteine, one of the water-soluble organosulfur garlic derivatives, was suggested to suppress the growth of gastric cancer in in vivo conditions because of its effect on antiproliferation, apoptosis induction, and the regulation of the MAPK and PI3K/Akt pathways (Zhu et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

Wan

Li³

et al. 2019

Food Science & Nutrition

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Previously, our meta‐analysis and other studies have suggested that allium vegetable consumption is beneficial for health, but no umbrella review has been conducted to assess the evidence of the various health benefits of allium vegetable consumption. Therefore, we conducted this umbrella review on this topic. This umbrella review included a total of 16 meta‐analyses with 50 unique outcomes. The most beneficial cancer‐related outcome was shown for gastric cancer (risk ratio 0.78; 95% confidence interval [CI] 0.67–0.91). In addition, only 8 weeks of garlic consumption significantly decreased serum total cholesterol (weighted mean differences −17.20 mg/dl; 95% CI −23.10 to −11.30), and patients with dyslipidemia who consumed garlic experienced more benefits than the whole population. Diabetic patients with longer durations of garlic intake experienced more benefits in terms of fasting blood glucose (FBG), HbA1c, and serum fructosamine than healthy participants, and garlic intake was associated with blood pressure reduction in hypertensive patients but not in normotensive participants. Limited side effects of garlic, such as garlic odor and gastrointestinal complaints, were reported among the included meta‐analyses. Our results suggested that allium vegetables might be beneficial for cancer prevention. In particular, garlic was comparatively safe and is recommended as a long‐term dietary component for patients with dyslipidemia, diabetes, and hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

Wan

Li³

et al. 2019

Food Science & Nutrition

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“…23 In ovarian cancer, ADAMTS9-AS2 affects the progression of ovarian cancer by targeting the miR-182-5p/FOXF2 signaling pathway. 30 In gastric cancer, aberrant expression of ADAMTS9-AS2 activates the PI3K-Akt signaling pathway to promote the development of gastric cancer cells. Functional enrichment analysis was performed on mRNAs linked to ADAMTS9-AS2.…”

Section: Relationship Between Lncrnamentioning

confidence: 99%

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

Wang

Ding

et al. 2019

J of Cellular Biochemistry

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The oncogenesis and progression of gastric cancer are closely correlated with the complex regulatory relationships among messenger RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA). After constructing the gastric cancer lncRNA‐miRNA‐mRNA regulatory network, we analyzed the network topology properties and found that lncRNA ADAMTS9‐AS2 and C20orf166‐AS1 and miRNA hsa‐mir‐204 are key nodes. Further functional enrichment analysis and survival analysis were performed on these key nodes and the RNAs interacting with them. We found that CHRM2, ANGPT2, and COL1A1 interacting with ADAMTS9‐AS2 are enriched in the PI3K‐Akt signaling pathway, and low expression of the ADAMTS9‐AS2 is closely related to the prognosis of patients. Abnormal expression of CACNA1H, FLNA, and FLNC interacting with lncRNA C20orf166‐AS1 is associated with MAPK signaling pathway in gastric cancer. In addition, the downregulated miRNA hsa‐mir‐204 promotes invasion and proliferation of gastric cancer cells by regulating the abnormal expression of mRNAs (CHRDL1 and NPTX1) and lncRNAs (ADAMTS9‐AS2, NKX2‐1‐AS1, TLR8‐AS1, and VCAN‐AS1). This study systematically analyzed the lncRNA‐miRNA‐mRNA regulatory network of gastric cancer, which not only has a new understanding of the pathogenesis of gastric cancer, but also provides new insights for the early diagnosis and treatment of gastric cancer.

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“…Huang et al suggested that gelsolin-PI3KAkt signaling was important for GC cell aggregation and may be a promising biomarker for the treatment of GC. Zhu et al found that S-allylmercaptocysteine suppressed GC cell proliferation, induced cell apoptosis, inhibited the PI3K/Akt pathway, and suppressed tumor growth in SGC-7901 xenografts [44].…”

Section: Topological Analyses Of the Gc Related Lncrna-mrna Networkmentioning

confidence: 99%

A Novel LncRNA-miRNA-mRNA Triple Network Identifies LncRNA RP11-363E7.4 as An Important Regulator of miRNA and Gene Expression in Gastric Cancer

Wang

Zhao

et al. 2018

Cell Physiol Biochem

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Background/Aims: Recent evidence has shown that some long non-coding RNAs (lncRNAs) play important roles in various biological processes. However, the regulatory mechanism of lncRNA in gastric cancer (GC) remains unclear. Methods: We reannotated the GC gene expression profile into a lncRNA-mRNA biphasic profile and integrated the microRNA target data to construct a global GC triple network. A further clustering and random walk with restart analyses was performed on the triple network from the level of topology analyses. Quantitative real-time PCR was used to determine expression of lncRNA RP11-363E7.4. Kaplan-Meier analyses was performed to evaluate the prognostic value of lncRNA RP11-363E7.4. Results: We constructed a gastric cancer lncRNA-miRNA-mRNA network (GCLMN) including six lncRNAs, 332 mRNAs, and 3,707 edges. For the shared lncRNA RP11-363E7.4, the interacting gene and microRNA functional enrichment studies implied that lncRNA RP11-363E7.4 might function as a new regulator in GC. The expression of lncRNA RP11-363E7.4 was downregulated compared with that of paracarcinoma tissues in five GC samples. High expression of lncRNA RP11-363E7.4 was found to be correlated to better overall survival (OS) for GC patients. Conclusions: This study focused on GC lncRNA-miRNA-mRNA regulatory networks, and found that lncRNA RP11-363E7.4 was a new GC risk lncRNA, which might provide novel insight into a better understanding of the pathogenesis of GC.

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S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways

Cited by 28 publications

References 22 publications

Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

A Novel LncRNA-miRNA-mRNA Triple Network Identifies LncRNA RP11-363E7.4 as An Important Regulator of miRNA and Gene Expression in Gastric Cancer

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