S-bridged complex of 99mTc with fac(S)-[Rh(aet)3]: Quality control, characterization and biodistribution studies in rats

Comparative studies of S-bridged complexes of 99mTc with fac(S)-[M(aet)3] (M=RhIII, IrIII; aet=2-aminoethanethiolate)

“…The amount of the reducing agent, SnCl 2 ·2H 2 O, which gave the highest labelling efficiency, was 30 µg (Fig. 2) similar to the Rh complex [28]. This was confirmed by generating the stability curves for each concentration of SnCl 2 ·2H 2 O.…”

“…In this work it is also proposed that an S-bridged polynuclear complex with 99m Tc is formed (Fig. 1) similar to [ 99m Tc{Rh(aet) 3 } 2 ] 3+ [28].…”

“…It was noted that the complex formed is fairly stable compared to Rh complex where the labelling reached to its maximum value in 20 min and decreased down in 60 min reaching to 62% in 240 min (Fig. 3) [28]. The effect of pH is shown in Fig.…”

“…The reaction of fac(S)-[Ir(aet) 3 ] with Na 99m TcO 4 in acidic solution (HCl) using SnCl 2 ·2H 2 O as a reducing agent at room temperature gave S-bridged complex expected to be [ 99m Tc{Ir(aet) 3 [24,25,28]. Technetium and rhenium have quite similar behavior as they belong to the same group in the periodic table.…”

“…In paper chromatography using acetone as the solvent, free 99m TcO 4 − moved towards the solvent front (R f = 1), while [ 99m Tc{Ir(aet) 3 [28] and also to [Re{M(aet) 3 } 2 ] 3+ (M = Rh III , Ir III ) where molar conductivity values showed that complex is positively charged [24,25]. The crystal structure of [Re{Ir(aet) 3 } 2 ] 3+ has been reported earlier showing a d 4 metal ion (Re) incorporated into S-bridged polynuclear structures [24,25].…”