S-Equol, an Antioxidant Metabolite of Soy Daidzein, and Oxidative Stress in Aging

Jackson, Richard L.; Greiwe, Jeffrey S.; Schwen, Richard J.

doi:10.1016/b978-0-12-405933-7.00015-9

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…This molecular mechanism has been described, where it involves the release of Nrf2 (transcription factor) from Keap 1 (its cytoplasmic binding protein) and subsequent binding to the antioxidant response element (ARE) that are present in the promoter region of genes for antioxidant proteins and enzymes [6,97]. Specifically, equol may increase Nrf2 levels and/or bind to the estrogen-responsive elements (EREs) in the promoter region the Nrf2 gene and/or increase gene expression of other antioxidant genes [2,97]. Support for this described mechanism was demonstrated by Zhang et al (2013) that showed S-equol protected against peroxide-induced endothelial cell apoptosis by activation of estrogen receptor and Nrf2/ARE signaling pathways [73].…”

Section: Equol Increases Skin Antioxidant Defense and Stimulates Nrf2mentioning

confidence: 99%

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Lephart

2018

Cosmetics

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Environmental pollutants represent a major problem worldwide that cannot be passively avoided. It is known that skin sensitivities can result from environmental assaults, such as toxins and pollutants in air and water. Additionally, dermal assaults from wind and exposure to seasonal cold temperatures are known. All of these environmental assaults are associated with oxidative stress and the intracellular generation of reactive oxygen species (ROS), which damage DNA, lipids, proteins and mitochondrial function. Additionally, the influence of diet on dermal health and, especially, antioxidant defense in skin function are well established. In this regard, environmental pollution worldwide has generated a high demand for anti-pollution personal care products to protect the skin against the daily exposure of airborne toxins and various other assaults. Major cosmetic companies have anti-pollution personal care products but, in general, the products are formulated with commonly used active ingredients that have been retooled with market strategies to address current environmental pollution treatments. Equol is a new botanical active ingredient compound for skin applications. It has a polyphenolic chemical structure found in plant and food products, and is also classified as an isoflavonoid. Moreover, equol appears to address the need for an active ingredient in personal care products to protect against pollution assaults by increasing antioxidant defense, while inhibiting oxidative stress and inflammation. Separate sections covering equol's enhanced (a) delivery mechanism into human skin; (b) antioxidant effects via Nrf2 activation; (c) effects on extracellular matrix proteins like collagen and elastin and; (d) protection against oxidative stress and inflammation are presented.

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Section: Equol Increases Skin Antioxidant Defense and Stimulates Nrf2mentioning

confidence: 99%

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Lephart

2018

Cosmetics

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Assessment of Antioxidant, Antimicrobial and Anticancer Activities and Chemical Composition of Bark of Mahonia napaulensis DC. of Nepal

Shrestha,

Nayak,

Maharjan

et al. 2024

Preprint

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Background Cancer is one of the major health problems worldwide and medicinal plants constitute a common alternative for cancer treatment having no or less side effects. This study was aimed to assess total phenolic (TPC) and flavonoid (TFC) contents, antioxidant, biological activities (especially antibacterial, antifungal and anticancer) and chemical composition of methanol extract of M. napaulensis DC. bark (MNBM). This is the first study of evaluating its anticancer activity and chemical composition by LC-MS/MS analysis. Methods TPC, TFC, antioxidant, antimicrobial and anticancer activities were determined by Folin-Ciocalteu, AlCl3, DPPH, resazurin and MTT assays, respectively. Its metabolite profiling was done by LC-MS/MS analysis. The statistical significance of differences between test groups was analyzed by one-way ANOVA test. Results The preliminary phytochemical screening revealed the presence of various phytochemicals viz. alkaloids, steroids, glycosides, polyphenols, tannins, flavonoids, coumarins, terpenoids and quinone. MNBM showed 38.00 ± 1.50 mg GAE g− 1 dry sample as TPC; 35.04 ± 4.87 mg QE g− 1 dry sample as TFC and 212.97 µg/mL IC50 value (P < 0.05) as moderate antioxidant activity. MNBM showed minimal inhibitory concentration (MIC) values 100.22 mg/mL, 50.15 mg/mL and 25.08 mg/mL against S. aureus, E. coli and C. albicans, respectively as weak antimicrobial activity. It did not show any antibacterial effect against B. cereus and P. aeruginosa at 120 mg/mL. The anticancer activity of MNBM was moderate against human lung cancer cells A549 (228.97 µg/mL IC50 value) and human cervical cancer cells HeLa (367.72 µg/mL IC50 value) (P < 0.05). The LC-MS/MS analysis reported the presence of different anticancer compounds viz. dihydroberberine, d-berbamine, (S)-glaucine, protopine, grosheimin, mycophenolic acid, berberine, alpha-linolenic acid etc. Conclusions MNBM showed the dose-dependent moderate antioxidant, weak antibacterial, weak antifungal and moderate anticancer activity due to the synergistic effect of different phytochemicals and anticancer compounds.

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S-Equol, an Antioxidant Metabolite of Soy Daidzein, and Oxidative Stress in Aging

Cited by 2 publications

References 59 publications

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Assessment of Antioxidant, Antimicrobial and Anticancer Activities and Chemical Composition of Bark of Mahonia napaulensis DC. of Nepal

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