S-(N,N-diethyldithiocarbamoyl)-N-acetyl-
            <scp>l</scp>
            -cysteine for the treatment of non-small cell lung cancer through regulating NF-κB signalling pathway without neurotoxicity

Lv, Huaiyou; Yang, Huatian; Duan, Yifei; Yan, Chongzheng; Li, Genju; Zhao, Guozhi; Sun, Fengqin; Feng, Yafei; Li, Yuhan; Fu, Yaqing; Li, Yizhe; Zhao, Zhongxi; Jia, Xiumei

doi:10.1080/1061186x.2024.2374037

Journal of Drug Targeting

2024

DOI: 10.1080/1061186x.2024.2374037

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S-(N,N-diethyldithiocarbamoyl)-N-acetyl- l -cysteine for the treatment of non-small cell lung cancer through regulating NF-κB signalling pathway without neurotoxicity

Huaiyou Lv,

Huatian Yang,

Yifei Duan

et al.

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Cited by 2 publications

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Unveiling ferroptosis: a new frontier in skin disease research

Wang,

Lin,

Zhou

et al. 2024

Front. Immunol.

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Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation and lipid peroxidation, ferroptosis has been implicated in the progression of various skin conditions, including psoriasis, photosensitive dermatitis, and melanoma. This review provides an in-depth analysis of the molecular mechanisms underlying ferroptosis and compares its cellular effects with other forms of cell death in the context of skin health and disease. We systematically examine the role of ferroptosis in five specific skin diseases, including ichthyosis, psoriasis, polymorphous light eruption (PMLE), vitiligo, and melanoma, detailing its influence on disease pathogenesis and progression. Moreover, we explore the current clinical landscape of ferroptosis-targeted therapies, discussing their potential in managing and treating skin diseases. Our aim is to shed light on the therapeutic potential of modulating ferroptosis in skin disease research and practice.

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Unveiling ferroptosis: a new frontier in skin disease research

Wang,

Lin,

Zhou

et al. 2024

Front. Immunol.

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Decoding ferroptosis: transforming orthopedic disease management

Huo,

Lin,

Liu

et al. 2024

Front. Pharmacol.

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As a mechanism of cell death, ferroptosis has gained popularity since 2012. The process is distinguished by iron toxicity and phospholipid accumulation, in contrast to autophagy, apoptosis, and other cell death mechanisms. It is implicated in the advancement of multiple diseases across the body. Researchers currently know that osteosarcoma, osteoporosis, and other orthopedic disorders are caused by NRF2, GPX4, and other ferroptosis star proteins. The effective relief of osteoarthritis symptoms from deterioration has been confirmed by clinical treatment with multiple ferroptosis inhibitors. At the same time, it should be reminded that the mechanisms involved in ferroptosis that regulate orthopedic diseases are not currently understood. In this manuscript, we present the discovery process of ferroptosis, the mechanisms involved in ferroptosis, and the role of ferroptosis in a variety of orthopedic diseases. We expect that this manuscript can provide a new perspective on clinical diagnosis and treatment of related diseases.

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S-(N,N-diethyldithiocarbamoyl)-N-acetyl- l -cysteine for the treatment of non-small cell lung cancer through regulating NF-κB signalling pathway without neurotoxicity

Cited by 2 publications

References 56 publications

Unveiling ferroptosis: a new frontier in skin disease research

Unveiling ferroptosis: a new frontier in skin disease research

Decoding ferroptosis: transforming orthopedic disease management

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