S-Nitroso compounds interfere with zinc probing by Zinquin

Jansen, Sven; Arning, Jürgen; Dülcks, Thomas; Beyersmann, Detmar

doi:10.1016/j.ab.2004.05.003

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…Many compounds are being tested to circumvent the limitation of radiotherapy, i.e., radioresistance (Warner et al 1993). Nitric oxide has been shown to have great clinical potential and is second most potent chemical radiosensitizer (Jansen et al 2004). Its direct anti-tumor actions and radiosensitizing properties have made it a center of attraction in cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Differential response of three cell types to dual stress of nitric oxide and radiation

2012

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The perception of toxicity to nitric oxide (NO) and irradiation (IR) by three different cell types has been studied. The three cell types are the macrophage like RAW264.7 cells, EL4 lymphoma cells, and splenocytes, which represent the different components of a tumor. These three cell types respond differently to NO donors (SNP and SNAP) and radiation treatment. The macrophages were found to be most radio-resistant and insensitive to NO donors. The innate resistance of the macrophages was not due to its antioxidant defense system since there was no significant activation of the enzymes (superoxide dismutases, catalase, and glutathione peroxidase) in RAW264.7 cells after NO donor and irradiation. But the cell cycle arrest of the three cell types was different from each other. The EL4 cells were found to arrest in the G2/M phase while the macrophages were found arrested in the G1 phase of the cell cycle. Such specific killing of the tumor cell in response to NO donor while sparing the macrophages can be of immense importance to radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Differential response of three cell types to dual stress of nitric oxide and radiation

2012

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Z

2010

Handbook of Biological Dyes and Stains

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Directed Neural Stem Cells Differentiation via Signal Communication with Ni–Zn Micromotors

Feng,

Gao,

Xie

et al. 2023

Advanced Materials

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Neural stem cells (NSCs), with the capability of self‐renewal, differentiation, and environment modulation, are considered promising for stroke, brain injury therapy, and neuron regeneration. Activation of endogenous NSCs, is attracting increasing research enthusiasm, which avoids immune rejection and ethical issues of exogenous cell transplantation. Yet, how to induce directed growth and differentiation in situ remain a major challenge. In this study, a pure water‐driven Ni–Zn micromotor via a self‐established electric–chemical field is proposed. The micromotors can be magnetically guided and precisely approach target NSCs. Through the electric–chemical field, bioelectrical signal exchange and communication with endogenous NSCs are allowed, thus allowing for regulated proliferation and directed neuron differentiation in vivo. Therefore, the Ni–Zn micromotor provides a platform for controlling cell fate via a self‐established electrochemical field and targeted activation of endogenous NSCs.

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S-Nitroso compounds interfere with zinc probing by Zinquin

Cited by 5 publications

References 15 publications

Differential response of three cell types to dual stress of nitric oxide and radiation

Differential response of three cell types to dual stress of nitric oxide and radiation

Z

Directed Neural Stem Cells Differentiation via Signal Communication with Ni–Zn Micromotors

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