S-nitrosothiol-terminated Pluronic F127: Influence of microstructure on nitric oxide release

Picheth, Guilherme Fadel; Silva, Laura C. E. da; Giglio, Leonardo P.; Plivelic, Tomás S.; Oliveira, Marcelo Ganzarolli de

doi:10.1016/j.jcis.2020.05.049

Cited by 12 publications

(9 citation statements)

References 47 publications

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“…The multiplets observed at δ H 3.20-3.90 ppm showed the presence of protons from sugar moiety [53], and the κ-carrageenan spectrum revealed a peak at δ H 3.56 ppm indicating O-methylene protons because of the presence of 3-linked 6-O-methyl-D-galactose residue present in κ-carrageenan [54]. Mahmood et al observed a similar effect with slight variation in chemical shift, which might be due to the difference in the source of the polymer obtained [55]. Compared with the spectra of the polymers, the injectable hydrogel showed a peak at δ H 1.07 ppm, which was also present in the spectrum of F127, belonging to the methyl group of PPO in F127.…”

Section: H Nmrmentioning

confidence: 90%

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

et al. 2022

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The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers good antibacterial properties. This study aimed to develop and evaluate biopolymer-based thermoreversible injectable hydrogels for effective wound-healing applications and the controlled drug delivery of meropenem. The injectable hydrogel was developed using the solvent casting method and evaluated for structural changes using proton nuclear magnetic resonance, Fourier transforms infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The results indicated the self-assembly of hyaluronic acid and kappa-carrageenan and the thermal stability of the fabricated injectable hydrogel with tunable gelation properties. The viscosity assessment indicated the in-situ gelling ability and injectability of the hydrogels at various temperatures. The fabricated hydrogel was loaded with meropenem, and the drug release from the hydrogel in phosphate buffer saline (PBS) with a pH of 7.4 was 96.12%, and the simulated wound fluid with a pH of 6.8 was observed to be at 94.73% at 24 h, which corresponds to the sustained delivery of meropenem. Antibacterial studies on P. aeruginosa, S. aureus, and E. coli with meropenem-laden hydrogel showed higher zones of inhibition. The in vivo studies in Sprague Dawley (SD) rats presented accelerated healing with the drug-loaded injectable hydrogel, while 90% wound closure with the unloaded injectable hydrogel, 70% in the positive control group (SC drug), and 60% in the negative control group was observed (normal saline) after fourteen days. In vivo wound closure analysis confirmed that the developed polymeric hydrogel has synergistic wound-healing potential.

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Section: H Nmrmentioning

confidence: 90%

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

et al. 2022

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“…Both microtechnology and nanotechnology are cutting-edge alternatives for therapeutic and diagnostic use in a wide variety of pathologies [ [88] , [89] , [90] ]. They are also employed to transport and deliver drugs, and other molecules such as oxygen and nitric oxide, allowing an increase in pO 2 [ 91 , 92 ]. The following section is intended to present and highlight the therapeutic results promoted by experimental or preclinical systems, which are potentially capable of carrying molecules that the body needs [ 93 ].…”

Section: Micro and Nanotechnology For Extracorporeal Oxygenationmentioning

confidence: 99%

Oxygen therapy alternatives in COVID-19: From classical to nanomedicine

Pereira¹,

Dallagnol²,

Moulepes³

et al. 2023

Heliyon

Self Cite

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“…This disease can sometimes cause severe visual impairment via infection with P. aeruginosa and S. Reproduced with permission. [159] Copyright 2020, Elsevier. B) Schematic representation of GH/GelSNO hydrogel formation and NO release by cleavage of S-N bonds under heat and light excitation.…”

Section: Hydrogels With Chemically Tethered No Donorsmentioning

confidence: 99%

Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide

Sarkar

Kumar

Matson

2023

Macromolecular Bioscience

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Gasotransmitters, gaseous signaling molecules including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), maintain myriad physiological processes. Low levels of gasotransmitters are often associated with specific problems or diseases, so NO, CO, and H2S hold potential in treating bacterial infections, chronic wounds, myocardial infarction, ischemia, and various other diseases. However, their clinical applications as therapeutic agents are limited due to their gaseous nature, short half‐life, and broad physiological roles. One route toward the greater application of gasotransmitters in medicine is through localized delivery. Hydrogels are attractive biomedical materials for the controlled release of embedded therapeutics as they are typically biocompatible, possess high water content, have tunable mechanical properties, and are injectable in certain cases. Hydrogel‐based gasotransmitter delivery systems began with NO, and hydrogels for CO and H2S have appeared more recently. In this review, the biological importance of gasotransmitters is highlighted, and the fabrication of hydrogel materials is discussed, distinguishing between methods used to physically encapsulate small molecule gasotransmitter donor compounds or chemically tether them to a hydrogel scaffold. The release behavior and potential therapeutic applications of gasotransmitter‐releasing hydrogels are also detailed. Finally, the authors envision the future of this field and describe challenges moving forward.

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S-nitrosothiol-terminated Pluronic F127: Influence of microstructure on nitric oxide release

Cited by 12 publications

References 47 publications

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

Oxygen therapy alternatives in COVID-19: From classical to nanomedicine

Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide

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