S-nitrosothiol-terminated poly(vinyl alcohol): Nitric oxide release and skin blood flow response

Giglio, Leonardo P.; Picheth, Guilherme Fadel; Løvschall, Kaja Borup; Zelikin, Alexander N.; Oliveira, Marcelo Ganzarolli de

doi:10.1016/j.niox.2020.03.002

Cited by 11 publications

(13 citation statements)

References 50 publications

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“…Moreover, an increase in the myofibroblastic differentiation and collagen type III expression in the scar tissue was observed with PVA‐SNO/F127 application. Recently, Giglio et al [131] . used a different methodology to synthesize PVA‐SNO films to obtain even longer release profiles.…”

Section: No‐releasing Therapies For Wound Healingmentioning

confidence: 99%

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Emerging Nitric Oxide and Hydrogen Sulfide Releasing Carriers for Skin Wound Healing Therapy

et al. 2021

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Nitric oxide (NO) and hydrogen sulfide (H2S) have been recognized as important signalling molecules involved in multiple physiological functions, including wound healing. Their exogenous delivery has been established as a new route for therapies, being the topical application the nearest to commercialization. Nevertheless, the gaseous nature of these therapeutic agents and their toxicity at high levels imply additional challenges in the design of effective delivery systems, including the tailoring of their morphology and surface chemistry to get controllable release kinetics and suitable lifetimes. This review highlights the increasing interest in the use of these gases in wound healing applications by presenting the various potential strategies in which NO and/or H2S are the main therapeutic agents, with focus on their conceptual design, release behaviour and therapeutic performance. These strategies comprise the application of several types of nanoparticles, polymers, porous materials, and composites as new releasing carriers of NO and H2S, with characteristics that will facilitate the application of these molecules in the clinical practice.

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Section: No‐releasing Therapies For Wound Healingmentioning

confidence: 99%

“…Blended PVA:PVA‐SNO films at different ratios showed NO release rates from 0.4 to 12 nmol g −1 min −1 and the chance of releasing NO continuously up to 6.2 hours. Topical application of PVA/PVA‐SNO films may lead to a 2‐ to 10‐fold dose‐response increase in the human skin blood flow [131] …”

Section: No‐releasing Therapies For Wound Healingmentioning

confidence: 99%

Emerging Nitric Oxide and Hydrogen Sulfide Releasing Carriers for Skin Wound Healing Therapy

et al. 2021

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“…The technology consists of a nitrite-functionalized PVA patch produced by reversible addition−fragmentation chain-transfer polymerization of nitrosothiols. Giglio et al tested the platform in vivo in healthy volunteers as a proof-of-concept and determined a significant increase in blood circulation with potential application in microvascular diseases [117].…”

Section: Circulatory Applicationsmentioning

confidence: 99%

Synthetic, Natural, and Semisynthetic Polymer Carriers for Controlled Nitric Oxide Release in Dermal Applications: A Review

2021

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Nitric oxide (NO•) is a free radical gas, produced in the human body to regulate physiological processes, such as inflammatory and immune responses. It is required for skin health; therefore, a lack of NO• is known to cause or worsen skin conditions related to three biomedical applications— infection treatment, injury healing, and blood circulation. Therefore, research on its topical release has been increasing for the last two decades. The storage and delivery of nitric oxide in physiological conditions to compensate for its deficiency is achieved through pharmacological compounds called NO-donors. These are further incorporated into scaffolds to enhance therapeutic treatment. A wide range of polymeric scaffolds has been developed and tested for this purpose. Hence, this review aims to give a detailed overview of the natural, synthetic, and semisynthetic polymeric matrices that have been evaluated for antimicrobial, wound healing, and circulatory dermal applications. These matrices have already set a solid foundation in nitric oxide release and their future perspective is headed toward an enhanced controlled release by novel functionalized semisynthetic polymer carriers and co-delivery synergetic platforms. Finally, further clinical tests on patients with the targeted condition will hopefully enable the eventual commercialization of these systems.

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“…Furthermore, the presence of the SNO group was verified by the UV-vis spectrum of PAA-SNO, which exhibited a characteristic band of the SNO group with a 𝜆 max of 327 nm assigned to 𝜋 → 𝜋* electron transition (Figure S1d, Supporting Information). [38] We engineered cellular surfaces using PAA-SNO and other functional materials for endothelial angiogenesis to apply NO to cells directly. Figure 2c lists three different building blocks.…”

Section: Design Of No-releasing Cell Coatingmentioning

confidence: 99%

A Nanocoating Co‐Localizing Nitric Oxide and Growth Factor onto Individual Endothelial Cells Reveals Synergistic Effects on Angiogenesis

Jeong

Choi

et al. 2021

Adv Healthcare Materials

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The delivery of nitric oxide (NO)-an intrinsic cellular signaling molecule-is promising for disease treatment, in particular to vascular diseases, due to its endothelial-derived inherent nature. The limited diffusion distance of labile NO prompts researchers to develop various carriers and targeting methods for specific sites. In contrast to the apoptotic effect of NO, such as anticancer, delivering low NO concentration at the desired targeting area is still intricate in a physiological environment. In this study, the layer-by-layer assembled nanocoating is leveraged to develop a direct NO delivery platform to individual endothelial cells (ECs). NO can be localized to individual ECs via S-nitrosothiol-bound polyacrylic acid which is a polymer directly providing an endothelial-like constant level of NO. To increase angiogenic activation along with NO, VEGF is additionally applied to specific receptors on the cell surface. Notably, the survival and proliferation of ECs are significantly increased by a synergistic effect of NO and VEGF co-localized via nanocoating. Furthermore, the nanocoating remarkably promoted cell migration and tubule formation-prerequisites of angiogenesis. The proposed unique technology based on nanocoating demonstrates great potential for conferring desired angiogenic functions to individual ECs through efficient NO delivery.

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S-nitrosothiol-terminated poly(vinyl alcohol): Nitric oxide release and skin blood flow response

Cited by 11 publications

References 50 publications

Emerging Nitric Oxide and Hydrogen Sulfide Releasing Carriers for Skin Wound Healing Therapy

Emerging Nitric Oxide and Hydrogen Sulfide Releasing Carriers for Skin Wound Healing Therapy

Synthetic, Natural, and Semisynthetic Polymer Carriers for Controlled Nitric Oxide Release in Dermal Applications: A Review

A Nanocoating Co‐Localizing Nitric Oxide and Growth Factor onto Individual Endothelial Cells Reveals Synergistic Effects on Angiogenesis

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